Cell Nucleus News and Research

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Researchers demonstrate direct transfer of terminally differentiated cell nuclei

With the advent of nuclear-transfer cloning, it is now possible to produce mice from the nuclei of differentiated cells, such as peripheral blood lymphocytes and olfactory sensory neurons.

20 Jun 2005

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Disruption of proteins expressed at the junctures between cells (known as tight junctions) is a hallmark of cancer cell invasion and spread (metastasis).

16 Jun 2005

Circadian clock gene also plays pivotal role in drug addiction

The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found.

13 Jun 2005

New understanding of jet lag

A new study demonstrates that the brain’s central timekeeper - the biological clock that regulates waking and sleeping cycles - has two parts that fall out of synchrony during light schedule shifts of six hours, the time it takes to fly across the Atlantic.

3 Jun 2005

Scientists have uncovered the structure of a network of proteins that help regulate the life cycle of cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws in the system that could lead to cancer.

2 Jun 2005

Scientists develop a way to block the signals responsible for neuropathic pain

Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it.

1 Jun 2005

Targeted Genetics issued patent related to adeno-associated virus (AAV) technology platform

Targeted Genetics Corporation has announced the issuance of another patent related to the Company's leading adeno-associated virus (AAV) technology platform. U.S. patent #6,897,045, titled "Adeno-Associated Virus Vectors," was issued to the University of Iowa Research Foundation and is exclusively licensed to Targeted Genetics.

30 May 2005

Protein, called "eed," crucial to the regulation of genes in embryonic stem cells

New research from University of North Carolina at Chapel Hill shows how a protein may be crucial to the regulation of genes in embryonic stem cells.

26 May 2005

Scientists show nuclear protein Ezh2 helps establish previously unknown signaling pathway in cells

Since 2001, scientists have wrestled with the discovery that there are fewer genes in humans than biological processes linked to those genes over the course of a human lifespan. One way to understand genetically coded events is by studying epigenetics, the regulation and heritability of genes at a cellular level due to molecular changes to the many proteins (called histones) that package DNA in a cell's nucleus.

23 May 2005

Researchers generate patient-specific stem cells

Researchers have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury.

20 May 2005

Basic brain mechanism that causes drug-seeking behavior

In studies with rats, researchers have distinguished a burst of the brain chemical dopamine from a reward-related brain region that is associated with anticipating the delivery of cocaine. The finding, publishing in the May 19 issue of Neuron, reveals the brain signal that likely underlies the fundamental motivation to obtain such drugs, said the scientists.

20 May 2005

Molecule found in liver cells could explain a lot about the relationship between diet, lipid levels in blood, and atherosclerosis

A team of researchers at the University of Pennsylvania School of Medicine have made a discovery that a molecule found in liver cells is important in explaining the relationship between diet, lipid levels in blood, and atherosclerosis.

15 May 2005

Research proves the dangers of salt

Sydney University scientists have proved that salt has a dangerous adrenalin-inducing effect on people suffering from high blood pressure, or 'hypertension'.

10 May 2005

Scientists extend the lifespan of mice

Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to the free-radical theory of aging.

5 May 2005

Researchers have successfully induced adult heart-muscle cells to divide and multiply

In the best documented effort to date, researchers from the Howard Hughes Medical Institute at Children's Hospital Boston and Harvard Medical School have successfully induced adult heart-muscle cells to divide and multiply.

3 May 2005

Researchers show protein's role in stopping bacterial-induced inflammation

In findings that could have implications for autoimmune disorders and drug-resistant bacterial infections, researchers at the University of California, San Diego (UCSD) School of Medicine have identified a key protein involved in the appropriate shut-down of inflammation following an immune response to invading pathogens.

28 Apr 2005

Isotopes for society

The nucleus of an atom contains protons and neutrons. However, some atoms of the same chemical element can have varying numbers of neutrons, giving so-called isotopes of that element.

27 Apr 2005

Substantially more effective therapy than current treatments for Alzheimer's disease

PET scans and cognitive tests have suggested that Alzheimer's disease patients with genetically modified tissue inserted directly into their brains show a reduction in the rate of cognitive decline and increased metabolic activity in the brain, according to a study published in the April 24, 2005 online issue of the journal Nature Medicine by researchers at the University of California, San Diego (UCSD) School of Medicine.

25 Apr 2005

Enzyme that helps trigger the development of leukemia

Scientists at the University of North Carolina at Chapel Hill have identified an enzyme that helps trigger the development of leukemia, a cancer of blood cells.

21 Apr 2005

Inherited variations in mitochondrial DNA linked to renal and prostate cancer

More than 20 million men in the United States with a particular signature set of inherited characteristics and mutations in mitochondrial DNA (mtDNA) are at significantly increased risk for developing renal and prostate cancers, according to research at Emory University.

20 Apr 2005