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Lipomannan on TB bacterium's outer cell surface can block TNF production

The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body's defense. New research suggests this represents a novel mechanism in the microbe's evolving efforts to remain hidden from the human immune system.

4 Oct 2011

Three Johns Hopkins scientists receive NIH Director's New Innovator Awards

A pioneer in the field of epigenetics who has been spearheading the use of genome-wide technology for epigenetics research, a researcher who has revealed a weakness in the tuberculosis bacterium that makes it more susceptible to antibiotics, and a scientist who seeks to revolutionize new methods for toxicological testing to improve human health and reduce animal testing have received Director's Awards from the National Institutes of Health.

22 Sep 2011

Redesigned vancomycin can kill deadliest antibiotic-resistant bacteria

A team of scientists from The Scripps Research Institute have successfully reengineered an important antibiotic to kill the deadliest antibiotic-resistant bacteria.

25 Aug 2011

Blocking type 2 receptor reduces PDA cell growth with the activation of AMPK enzyme

Pancreatic cancer researchers at Thomas Jefferson University have shown, for the first time, that blocking a receptor of a key hormone in the renin-angiotensin system (RAS) reduces cancer cell growth by activating the enzyme AMPK to inhibit fatty acid synthase, the ingredients to support cell division.

11 Aug 2011

Scientists identify bacterial attack pathway

When competing for food and resources, bacteria employ elaborate strategies to keep rival cells at bay. Scientists have now identified a pathway that allows disease-causing bacteria to attack other bacterial cells by breaking down their cell wall.

22 Jul 2011

Maltodextrin-based imaging probes could improve diagnosis and treatment of bacterial infections

A new family of contrast agents that sneak into bacteria disguised as glucose food can detect bacterial infections in animals with high sensitivity and specificity. These agents -- called maltodextrin-based imaging probes -- can also distinguish a bacterial infection from other inflammatory conditions.

21 Jul 2011

Study: 'The wave of death' may not indicate onset of brain death

The wave-shaped signal, which was previously dubbed 'the wave of death', had already been measured by researchers in Nijmegen in the brains of rats that had just been decapitated. The rats had already had electrodes implanted in their brains before the experiment.

18 Jul 2011

Copenhagen chemist reveals mechanism behind deadly infections

Anthrax, septicemia and meningitis are some of the planet's most deadly infections. In part because doctors lack basic insights to prevent and cure diseases caused by so called Gram-positive bacteria. Now, a chemist from the University of Copenhagen has revealed the mechanism behind these deadly infections.

24 Jun 2011

Scientists find altering hormone levels change cellular development in brain

In a study that increases the understanding of the link between fetal development and obesity later in life, researchers at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) found altering the levels of two common hormones, insulin and leptin, in utero changes the cellular development in the region of the brain that regulates appetite.

23 Jun 2011

Consumption of high-fat food causes more insulin to be released by the pancreas and leads to obesity

Fat-rich food makes you fat. Behind this simple equation lie complex signalling pathways, through which the neurotransmitters in the brain control the body's energy balance.

7 Jun 2011

MreB protein molecules assemble into larger units in bacterial cell wall

Almost all bacteria owe their structure to an outer cell wall that interacts closely with the supporting MreB protein inside the cell. As scientists at the Max Planck Institute for Biochemistry and at the French INRA now show, MreB molecules assemble into larger units, but not - as previously believed - into continuous helical structures.

4 Jun 2011

Scientists develop carbohydrate-based vaccine against C. difficile infection

There is now a promising vaccine candidate for combating the pathogen which causes one of the most common and dangerous hospital infections. An international team of scientists from the Max Planck Institute of Colloids and Interfaces in Potsdam has developed a vaccine based on a carbohydrate against the Clostridium difficile bacterium, which is known to cause serious gastrointestinal diseases mainly in hospitals.

31 May 2011

Endo and Bioniche present Urocidin Phase III trial preliminary results at 2011 AUA annual meeting

Endo Pharmaceuticals and Bioniche Life Sciences today presented Phase III trial results for the intravesical formulation of Mycobacterial cell wall-DNA complex (MCC), known as Urocidin, during a podium presentation at the 2011 American Urological Association annual meeting in Washington, D.C.

18 May 2011

'Iceman' influences autonomic nervous system and immune response

At the Radboud University Nijmegen Medical Centre, professor of experimental intensive care medicine dr. Peter Pickkers and his team have performed research on "Iceman" Wim Hof. Hof claims that he can influence his autonomic nervous system and immune response through concentration and meditation.

22 Apr 2011

Plant hormone auxin acts as a signalling molecule in embryo development

During the development of organisms, a particular event repeatedly occurs: a signal appears temporarily, but the processes it triggers must be maintained - for example, when the fate of cells in the embryo is established.

20 Apr 2011

New substance to tackle drug resistant tuberculosis

This year's World Health Day focuses on the growing threat of potentially deadly infections developing resistance to antimicrobial drugs - especially to antibiotics. On this occasion, the European Commission is presenting the promising results of two EU-funded international research projects which provide new hopes to help and treat people.

8 Apr 2011

New ‘nanotech’ weapon against drug-resistant superbugs

Scientists at the Institute of Bioengineering and Nanotechnology (IBN) and IBM Research – Almaden have developed the first biodegradable polymer nanoparticles to combat drug-resistant superbugs, such as Methicillin-Resistant Staphylococcus aureus (MRSA). These nanoparticles can selectively kill the bacteria without destroying healthy red blood cells, and being biodegradable, have great potential to treat infectious diseases in the body. This was reported today in the leading scientific journal, Nature Chemistry [(2011) DOI: 10.1038/nchem.1012].

3 Apr 2011

Urocidin Phase III non-muscle-invasive bladder cancer trial interim results to be presented at EAU, AUA conferences

Endo Pharmaceuticals and Bioniche Life Sciences Inc. today announced plans for peer-reviewed presentation of interim efficacy and safety results from the first Phase III trial of the intravesical formulation of Mycobacterial cell wall-DNA complex (MCC), known as Urocidin™ or EN3348.

18 Feb 2011

Research: Plants may assist in detecting environmental contaminants, explosives

Someday, that potted palm in your living room might go from green to white, alerting you to a variety of nasty contaminants in the air, perhaps even explosives.

16 Feb 2011

Study sheds new light on riboswitch that turns genes on or off in response to cell's energy needs

Scientists from The Scripps Research Institute have shed new light on a molecular switch that turns genes on or off in response to a cell's energy needs.

13 Feb 2011