Cell Wall News and Research

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Ultra-sensitive nanoprobes help tackle MRSA

This week Nature Nanotechnology journal (October 12th) reveals how scientists from the London Centre for Nanotechnology (LCN) at University College London are using a novel nanomechanical approach to investigate the workings of vancomycin, one of the few antibiotics that can be used to combat increasingly resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA).

12 Oct 2008

Many receptor models used in drug design may not be useful after all

It may very well be that models used for the design of new drugs have to be regarded as impractical. This is the sobering though important conclusion of the work of two Leiden University scientists published in Science this week.

5 Oct 2008

New antibiotics to fight MRSA

A new paper by Shahriar Mobashery, Navari Family Professor in Life Sciences at the University of Notre Dame, and researchers in his lab provides important insights into promising new antibiotics aimed at combating MRSA.

28 Jul 2008

Potential treatment for TB solves puzzle

Scientists have uncovered a new target for the potential treatment of TB, finally resolving a long-running debate about how the bacterial cell wall is built.

13 Jul 2008

Gene silencer and quantum dots reduce protein production to a whisper

More than 15 years ago, scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells.

9 Jul 2008

New target for the potential treatment of tuberculosis

Scientists have uncovered a new target for the potential treatment of tuberculosis (TB), finally resolving a long-running debate about how the bacterial cell wall is built.

3 Jul 2008

Quantum dots stop RNA interference in living cells

More than 15 years ago scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells.

24 Jun 2008

Plant flavonoid luteolin reduces inflammatory response in the brain

Researchers at the University of Illinois report this week that a plant compound found in abundance in celery and green peppers can disrupt a key component of the inflammatory response in the brain. The findings have implications for research on aging and diseases such as Alzheimer's and multiple sclerosis.

20 May 2008

Research could put penicillin back in battle against antibiotic resistant bugs

Research led by the University of Warwick has uncovered exactly how the bacterium Streptococcus pneumoniae has become resistant to the antibiotic penicillin.

13 Mar 2008

Curing cancer with natural products - a case for shamans and herb women?

Not at all, for many chemotherapies to fight cancer applied in modern medicine are natural products or were developed on the basis of natural substances. Thus, taxanes used in prostate and breast cancer treatment are made from yew trees. The popular periwinkle plant, which grows along the ground of many front yards, is the source of vinca alkaloids that are effective, for example, against malignant lymphomas. The modern anti-cancer drugs topotecan and irinotecan are derived from a constituent of the Chinese Happy Tree.

6 Mar 2008

New insights into what happens on a molecular level during photosynthesis

In a technical advance that could allow researchers to watch cells as they act during the process of photosynthesis, scientists have developed a method that extends the power of fluorescence-mediated bio-imaging to see discrete pigments inside live cells of bacteria.

6 Mar 2008

Bioniche receives fast track for bladder cancer therapy

Bioniche Life Sciences Inc. has announced that it has received notice from the U.S. Food and Drug Administration (FDA) that its therapy for first-line non-muscle-invasive bladder cancer meets the criteria for Fast Track designation.

6 Mar 2008

Moss protein plays role in Alzheimer's disease

Preventing Alzheimer's from developing is a goal of Raphael Kopan, Ph.D., professor of molecular biology and pharmacology at the Washington University School of Medicine.

11 Feb 2008

New insights into Legionella pneumophila

A study published online in Genome Research (www.genome.org) describes new insights into Legionella pneumophila, the bacteria responsible for most cases of Legionnaires' disease.

7 Feb 2008

Improved methods for decontamination of bioterrorism hazards

In October 2001, letters containing anthrax spores were mailed to several news media offices and two U.S. senators, killing five people and infecting 17 others.

30 Jan 2008

What makes some clays powerful antimicrobial agents?

With funding from the National Institutes of Health-National Center for Complementary and Alternative Medicine, the UB geologists are studying the surface characteristics of a broad range of naturally occurring antimicrobial clays, including some clays from France to determine why they are such effective killers of bacteria.

29 Oct 2007

Molecular basis of the cyanide polymorphism

That clover necklace you make for your child could well be a ring of poison.

2 Oct 2007

GlaxoSmithKline to pursue novel antibacterial research program for DOD

GlaxoSmithKline has announced that it has signed an agreement with the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense (DOD), to identify and develop a new class of antibacterials targeting both Gram negative biothreats and conventional Gram negative hospital pathogens.

18 Sep 2007

Nanoparticle that delivers vaccines more effectively

Good news for public health: Bioengineering researchers from the EPFL in Lausanne, Switzerland, have developed and patented a nanoparticle that can deliver vaccines more effectively, with fewer side effects, and at a fraction of the cost of current vaccine technologies.

18 Sep 2007

Bad news for disease-causing bacteria!

Scientists have what could be some very bad news for disease-causing bacteria. All three major classes of antibiotics that kill infectious bacteria do so in part by ramping up the production of harmful free radicals, researchers report in the September 7, 2007, issue of Cell, a publication of Cell Press.

10 Sep 2007