Chagas Disease News and Research

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Chagas (pronounced SHA-gus) disease is named after the Brazilian physician Carlos Chagas, who discovered it in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors that are found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

People can become infected in various ways. In Chagas-endemic areas, the main way is through vectorborne transmission. The insect vectors are called triatomine bugs. These blood-sucking bugs get infected by biting an infected animal or person. Once infected, the bugs pass T. cruzi parasites in their feces. The bugs are found in houses made from materials such as mud, adobe, straw, and palm thatch. During the day, the bugs hide in crevices in the walls and roofs. During the night, when the inhabitants are sleeping, the bugs emerge. Because they tend to feed on people’s faces, triatomine bugs are also known as “kissing bugs.” After they bite and ingest blood, they defecate on the person. The person can become infected if T. cruzi parasites in the bug feces enter the body through mucous membranes or breaks in the skin. The unsuspecting, sleeping person may accidentally scratch or rub the feces into the bite wound, eyes, or mouth.
Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

World Health Organization, Sanofi sign new agreement to eliminate neglected tropical diseases

World Health Organization, Sanofi sign new agreement to eliminate neglected tropical diseases

Study shows how parasite that causes Chagas disease resists current therapies

Study shows how parasite that causes Chagas disease resists current therapies

New, effective CRISPR-based gene drive approach to control transmission of malaria parasites

New, effective CRISPR-based gene drive approach to control transmission of malaria parasites

More intensive, less frequent drug regimen could cure Chagas disease

More intensive, less frequent drug regimen could cure Chagas disease

New position statement clarifies WHO's stance on the use of genetically modified mosquitoes

New position statement clarifies WHO's stance on the use of genetically modified mosquitoes

Bayer supports WHO through donated medicines for treatment of T. solium infection

Bayer supports WHO through donated medicines for treatment of T. solium infection

New chemical could potentially lead to a cure for neglected tropical diseases

New chemical could potentially lead to a cure for neglected tropical diseases

JGU professor wins Exploration Grant for research into membrane proteins of parasites

JGU professor wins Exploration Grant for research into membrane proteins of parasites

An extended SAR analysis of lipophilic guanylhydrazone analogues as promising trypanocidal agents

An extended SAR analysis of lipophilic guanylhydrazone analogues as promising trypanocidal agents

Novartis and DNDi to partner on development of new oral treatment for visceral leishmaniasis

Novartis and DNDi to partner on development of new oral treatment for visceral leishmaniasis

Clemson researchers discover protein function in parasites which afflict millions with diseases

Clemson researchers discover protein function in parasites which afflict millions with diseases

New compendium on cardiomyopathies

New compendium on cardiomyopathies

International consortium to receive BRL 43.5 million for discovering drugs to treat neglected diseases

International consortium to receive BRL 43.5 million for discovering drugs to treat neglected diseases

'African eye worm' hampers efforts to eliminate river blindness, study shows

'African eye worm' hampers efforts to eliminate river blindness, study shows

Detailed imaging of trypanosome paves way for new opportunities to combat sleeping sickness

Detailed imaging of trypanosome paves way for new opportunities to combat sleeping sickness

Alzheimer’s drug an interesting candidate for the treatment of parasitic Chagas disease

Alzheimer’s drug an interesting candidate for the treatment of parasitic Chagas disease

Discovery of protein that may be key to treating tropical diseases

Discovery of protein that may be key to treating tropical diseases

Preventing parasites from adhering to mosquito guts could stop disease transmission

Preventing parasites from adhering to mosquito guts could stop disease transmission

People successfully treated for visceral leishmaniasis can still infect others, study confirms

People successfully treated for visceral leishmaniasis can still infect others, study confirms