Chagas Disease News and Research

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Chagas (pronounced SHA-gus) disease is named after the Brazilian physician Carlos Chagas, who discovered it in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors that are found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

People can become infected in various ways. In Chagas-endemic areas, the main way is through vectorborne transmission. The insect vectors are called triatomine bugs. These blood-sucking bugs get infected by biting an infected animal or person. Once infected, the bugs pass T. cruzi parasites in their feces. The bugs are found in houses made from materials such as mud, adobe, straw, and palm thatch. During the day, the bugs hide in crevices in the walls and roofs. During the night, when the inhabitants are sleeping, the bugs emerge. Because they tend to feed on people’s faces, triatomine bugs are also known as “kissing bugs.” After they bite and ingest blood, they defecate on the person. The person can become infected if T. cruzi parasites in the bug feces enter the body through mucous membranes or breaks in the skin. The unsuspecting, sleeping person may accidentally scratch or rub the feces into the bite wound, eyes, or mouth.

Chagas' disease needs more research attention

The international research community needs to focus more attention on Chagas' disease - an infectious disease that kills 50,000 people a year, states an Editorial in this week's special cardiology issue of The Lancet.

17 Aug 2006

Night blindness is a new clinical symptom of Chagas disease

"This is a new observation, a new clinical symptom of Chagas disease," said Levin, head of the Laboratory of the Molecular Biology of Chagas Disease at the University of Buenos Aires, Argentina. Levin and colleagues report their findings in the March 2006, issue of the FASEB Journal.

1 Mar 2006

Argentina and Brazil join forces to produce AIDS drugs

Argentina's Health Ministry has announced that in partnership with the Brazilian government they plan to produce their own anti-AIDS drugs in an effort to lower the cost of treatment.

19 Jan 2006

Inexpensive blood test for major parasitic diseases

The National Reference Centre for Parasitology (NRCP), based at the MUHC, is developing a comprehensive and inexpensive blood safety test that will allow clinicians to check for all major parasitic diseases in patients' blood.

5 Dec 2005

Wellcome Trust awards £8.1 million to tackle tropical diseases

The Wellcome Trust, one of the world’s largest medical charities, has awarded £8.1 million over 5 years to a team of six scientists at the University of Dundee to help discover new drugs to treat some of the world’s most neglected tropical diseases.

25 Oct 2005

Genomes of Trypanosoma brucei and Trypanosoma cruzi sequenced

Oxford scientists have contributed to the genome sequencing of two parasites which cause major health problems in the developing world.

15 Aug 2005

Genome studies may help target new drugs to fight them

One parasite causes a deadly sleeping sickness in Africa. The second damages the internal organs of millions of Latin Americans. The third causes terrible lesions on the face or limbs of victims from Brazil to India.

18 Jul 2005

Scientists sequence the genomes of three species of parasites responsible for causing diseases that kill or cripple millions

Howard Hughes Medical Institute (HHMI) scientists who participated in the project say the sequencing of the genomes of the parasitic protozoa that cause Chagas disease, African sleeping sickness, and leishmaniasis, could significantly impact world health. Some of the genes discovered may prove to be good drug and vaccine targets.

17 Jul 2005

State-of-the-art computer technology to tackle deadly diseases such as influenza

Researchers at the University of Bath have won a £261,000 grant to use the latest software to produce a blueprint of a designer drug that could stop influenza and some other diseases from replicating in humans.

22 Feb 2005

Priorities on dealing with the big 3 infectious diseases - HIV/AIDS, TB, and malaria

The author of a Viewpoint article published online by THE LANCET argues for a renewed public-health effort to tackle so-called ‘neglected diseases’ which continue to have serious impact in less-developed countries.

13 Jul 2004

The Howard Hughes Medical Institute commits $30 million to beat infectious diseases

The Howard Hughes Medical Institute (HHMI) is stepping up its commitment to fostering international biomedical research with two new competitions for more than $30 million in research grants to biomedical scientists outside the United States. Both competitions are aimed at promising researchers whose careers are still developing and who are the most likely targets of enticing job offers in more economically privileged countries.

13 Apr 2004