Chagas Disease News and Research

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Chagas (pronounced SHA-gus) disease is named after the Brazilian physician Carlos Chagas, who discovered it in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors that are found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

People can become infected in various ways. In Chagas-endemic areas, the main way is through vectorborne transmission. The insect vectors are called triatomine bugs. These blood-sucking bugs get infected by biting an infected animal or person. Once infected, the bugs pass T. cruzi parasites in their feces. The bugs are found in houses made from materials such as mud, adobe, straw, and palm thatch. During the day, the bugs hide in crevices in the walls and roofs. During the night, when the inhabitants are sleeping, the bugs emerge. Because they tend to feed on people’s faces, triatomine bugs are also known as “kissing bugs.” After they bite and ingest blood, they defecate on the person. The person can become infected if T. cruzi parasites in the bug feces enter the body through mucous membranes or breaks in the skin. The unsuspecting, sleeping person may accidentally scratch or rub the feces into the bite wound, eyes, or mouth.
Researchers use multi-modal integrated approach to develop potential anti-Chagas therapies

Researchers use multi-modal integrated approach to develop potential anti-Chagas therapies

UCR study identifies new animal hosts of kissing bugs that spread Chagas disease

UCR study identifies new animal hosts of kissing bugs that spread Chagas disease

FDA grants accelerated approval to new treatment for children with Chagas disease

FDA grants accelerated approval to new treatment for children with Chagas disease

UTEP researchers move one step closer to developing first-ever Chagas disease vaccine

UTEP researchers move one step closer to developing first-ever Chagas disease vaccine

WHO marching toward extraordinary progress against neglected tropical diseases, report reveals

WHO marching toward extraordinary progress against neglected tropical diseases, report reveals

Atomic resolution structure of key molecule may contribute to drug discovery for devastating conditions

Atomic resolution structure of key molecule may contribute to drug discovery for devastating conditions

Chagas disease confirmed as 'silent killer' in first large-scale US survey

Chagas disease confirmed as 'silent killer' in first large-scale US survey

Research unravels how cytokines prevent multi-organ damage during parasitic infection

Research unravels how cytokines prevent multi-organ damage during parasitic infection

GHIT Fund invests in phase 3 clinical trial for pediatric formulation of ‘snail fever’ drug

GHIT Fund invests in phase 3 clinical trial for pediatric formulation of ‘snail fever’ drug

Parasite's biological clock could help improve treatments for deadly sleeping sickness

Parasite's biological clock could help improve treatments for deadly sleeping sickness

New study proves that 'super-boosting' approach may help treat children co-infected with TB and HIV

New study proves that 'super-boosting' approach may help treat children co-infected with TB and HIV

Scientists discover potential new target for protective vaccines against Chagas disease

Scientists discover potential new target for protective vaccines against Chagas disease

Experts receive $5.2 million NIH grant to develop affordable test for diagnosing Chagas disease

Experts receive $5.2 million NIH grant to develop affordable test for diagnosing Chagas disease

NIH funds collaborative project to develop better vaccine adjuvants for many diseases

NIH funds collaborative project to develop better vaccine adjuvants for many diseases

New compound could kill parasites of three neglected diseases

New compound could kill parasites of three neglected diseases

Ortho Clinical Diagnostics to showcase seven posters of vital tests, six products at AACC meeting

Ortho Clinical Diagnostics to showcase seven posters of vital tests, six products at AACC meeting

New multicomponent reactions to develop active compounds against sleeping sickness

New multicomponent reactions to develop active compounds against sleeping sickness

GMU’s early-detection urine test works for Lyme disease, study shows

GMU’s early-detection urine test works for Lyme disease, study shows

Innovative HIV vaccine candidate generates protection against repeated AIDS virus exposures

Innovative HIV vaccine candidate generates protection against repeated AIDS virus exposures

Humans can tolerate parasites responsible for sleeping sickness, Chagas disease, leishmaniasis

Humans can tolerate parasites responsible for sleeping sickness, Chagas disease, leishmaniasis