Chemoradiotherapy News and Research

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Chemoradiotherapy is a treatment that combines chemotherapy with radiation therapy. Also called chemoradiation.

Clinical trial examining the combination of atezolizumab and chemoradiation for patients with limited-stage SCLC reaches accrual

The NRG Oncology/Alliance clinical trial NRG-LU005, examining the addition of the immunotherapy drug atezolizumab combined with chemoradiation for patients with limited-stage small cell lung cancer (SCLC) recently reached the trial's accrual goal of 506 patients.

8 Jul 2022

Immunotherapy combined with chemoradiation and surgery could help treat nonmetastatic gastroesophageal cancer

Immunotherapy has transformed treatment for patients with stage 4 metastatic esophageal and gastric cancers. In patients with these malignancies, immunotherapy has been shown to prolong survival when patients' tumors exhibit a high expression of an immune-related protein called PD-L1.

16 May 2022

Trial shows safety and immunogenicity of immunotherapy with chemoradiation in cervical cancer patients

A Phase I/Ib trial conducted by the National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group NRG Oncology, NRG-GY017, concluded that the addition of the immunotherapy drug atezolizumab prior to and concurrently given with chemoradiation (CRT) treatment was safe for women with node-positive, locally advanced cervical cancer.

19 Mar 2022

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care investigated whether nivolumab has an added benefit over watchful waiting in the adjuvant treatment of adults with carcinoma of the esophagus or the gastroesophageal junction and pathological residual disease after prior neoadjuvant chemoradiotherapy (CRT).

10 Dec 2021

Chromosome aberrations linked to acute toxicities in esophageal cancer patients

Japanese researchers identified chromosome aberrations as a new biomarker in predicting an esophageal cancer patient's risk of experiencing severe chemoradiotherapy side effects.

28 Oct 2021

Investigational Oncomagnetic Device shrinks end-stage recurrent glioblastoma

Houston Methodist Neurological Institute researchers from the department of neurosurgery shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient wore on his head while administering the therapy in his own home.

22 Jul 2021

Older patients often do not receive optimal therapy for esophageal cancers due to perceived risks

Elderly patients (70 years and over) with locally advanced esophageal (E) and esophagogastric junction (EGJ) cancer (located in the stomach and esophagus) should be considered for optimal therapy that has the potential to cure.

9 Feb 2021

Study: Anal intraepithelial neoplasia is a precursor lesion for anal squamous cell carcinomas

Oncotarget recently published "PD-1/PD-L1 expression in anal squamous intraepithelial lesions" which reported that the presence and distribution of CD8 lymphocytes and the presence of PD-1 lymphocytes and PD-L1 epithelial cells were assessed.

12 Jan 2021

Japanese woman diagnosed with frosted branch angiitis

Leukemias and lymphomas are life-threatening malignancies affecting white blood cells and the immune system; fortunately, radiotherapy and chemotherapy, combined with stem cell therapy, can improve survival significantly.

10 Nov 2020

Researchers develop mitochondrial-targeted prodrug for treating glioblastoma

Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug.

9 Oct 2020

New bioluminescent reporter developed to track DNA double stranded break repair

A new bioluminescent reporter that tracks DNA double stranded break repair in cells has been developed by researchers from Massachusetts General Hospital and the Academia Sinica in Taiwan.

21 Aug 2020

Shorter-course radiotherapy will benefit bowel cancer patients during COVID-19

An international panel of cancer experts has recommended a one-week course of radiotherapy and delaying surgery as the best way to treat patients with bowel cancer during the COVID-19 pandemic.

6 Apr 2020

Combination of radiation and immunotherapy shows promise for advanced head and neck cancers

A new phase II trial finds that a combination of radiation therapy and immunotherapy led to encouraging survival outcomes and acceptable toxicity for patients with locally advanced head and neck squamous cell carcinoma

27 Feb 2020

'Watch-and-Wait' strategy may help rectal cancer patients to safely evade surgery

A team of doctors and scientists from the Champalimaud Clinical Centre in Lisbon, Portugal, and the Netherlands Cancer Institute in Amsterdam, has shown that patients with "low" rectal cancer (that is, very close to the anus) who show no sign of their tumors after a course of radio- and chemotherapy can safely choose to postpone invasive and complication-prone surgical procedures.

6 Feb 2020

Study: Chemoradiation regimen for Stage III NSCLC is better than two tested alternatives

Lung cancer is the leading cause of cancer death in the United States and approximately 75-80% of all cases are non-small cell lung cancer (NSCLC).

17 Dec 2019

Immunotherapy after CRT is safe in curative treatment of women with node-positive cervical cancer

Results from the NRG Oncology phase I clinical trial NRG-GOG 9929 show that utilizing the immunotherapy drug ipilimumab after chemoradiotherapy (CRT) is tolerated in the curative treatment of women with lymph node-positive cervical cancer.

2 Dec 2019

UK aims to lead with cutting-edge radiation therapy

The UK is all set to launch its run into the future as the undisputed leader in the field of personalized and effective radiation therapy. The proposal is undergirded by a whopping £56 million, which will be used to set up and fund advanced radiation therapy research by a new collaborative setup, Cancer Research UK RadNet, over five years. This is the largest sum ever invested by this organization into radiotherapy research.

4 Nov 2019

Artificial intelligence helps improve diagnosis of head and neck cancers

Researchers from Charité - Universitätsmedizin Berlin and the German Cancer Consortium have successfully solved a longstanding problem in the diagnosis of head and neck cancers.

12 Sep 2019

Cancer killing capability of lesser-known immune cells identified

Researchers at Trinity College Dublin have identified, for the first time in esophageal cancer, the cancer killing capability of a lesser-known type of immune cell, presenting a new potential therapeutic target.

10 Jul 2019

Researchers find characteristics related to better outcomes in HPV-linked oropharyngeal cancer

Using a new blood test that's in development, University of North Carolina Lineberger Comprehensive Cancer Center researchers identified characteristics that could be used to personalize treatment for patients with a type of head and neck cancer linked to HPV infection.

16 Jun 2019