Chloroquine News and Research

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Drugs considered for COVID-19 can increase risk for dangerous arrhythmias

As some consider treating coronavirus patients with a combination of the malaria drug hydroxychloroquine and the antibiotic azithromycin, cardiologists are advising caution because both medications can increase the risk for dangerous abnormal heart rhythms.

2 Apr 2020

Putting an end to the pandemic

From the plagues of medieval Europe to the influenza pandemic of 1918, the specter of the next public health disaster has gripped the minds of scientists, captivated the imaginations of writers and vexed conspiracy theorists.

1 Apr 2020

FDA to trial malaria drugs Chloroquine and Hydroxychloroquine for COVID-19

The U.S. Food and Drug Administration (FDA) this week provided the necessary authorization for clinical trials of chloroquine and hydroxychloroquine for the treatment of the novel coronavirus. These two drugs have been claimed by President Donald Trump to be a potential treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes COVID-19 disease. To date, there has been no conclusive proof regarding the safety and efficacy of these drugs in COVID-19 cases, say officials.

31 Mar 2020

Online coronavirus tests are just the latest iffy products marketed to anxious consumers

Companies with experience in the "at-home" testing market began announcing in mid-March that they would be offering direct-to-consumer test kits for COVID-19.

31 Mar 2020

Will 'old faithful' tuberculosis BCG vaccine work against COVID?

All over the world, except in China, the place where it all began, the COVID-19 pandemic is making its relentless way through the population. So far, it has caused nearly 34,000 deaths – and the situation in the US is still worsening with over 142,000 cases and 2,489 deaths. In Australia, the number of cases has climbed to 4,093, with 16 fatalities.

29 Mar 2020

Critical guidance to identify COVID-19 patients at risk of drug-induced sudden cardiac death

SARS-CoV-2, the virus that causes COVID-19, continues to spread, leading to more than 20,000 deaths worldwide in less than four months. Efforts are progressing to develop a COVID-19 vaccine, but it's still likely 12 to 18 months away.

25 Mar 2020

Huge WHO trial of COVID-19 therapies begins

As the world reels from the devastating impact and the looming threat of the novel coronavirus COVID-19, researchers around the globe are racing to find a cure that will reduce symptom severity and reverse the course of the disease, freeing up more hospital space and making it possible to treat more of the severely affected cases.

24 Mar 2020

Researchers highlight urgent need for public health leadership during COVID-19 pandemic

For decades, public health officials have directed the containment of emerging pandemics - perhaps most notably - the worldwide eradication of smallpox starting in the early to mid-1960s.

19 Mar 2020

Autophagy genes work against tumors in some ovarian cancers

Shedding light on a decades-old controversy, scientists at the Medical University of South Carolina and University of California at San Diego published findings in PLOS Genetics this month showing that autophagy or "self-eating" genes work against tumors in certain types of ovarian cancer.

13 Feb 2020

To fight Chinese outbreak, doctors deploy drugs targeting HIV, malaria and Ebola

As the scientific community scrambles to find a drug that can effectively treat tens of thousands of patients sickened by a new respiratory virus, they are trying some surprising remedies: medicines targeting known killers like HIV, Ebola and malaria.

13 Feb 2020

Molecular-level understanding of drug interactions could pave way for better malaria treatments

The process of crystallization is central to drug development, petrochemical processing and other industrial actions, but scientists say they still are learning about the complex interactions involved in the building and dissolution of crystals.

16 Jan 2020

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes.

31 Dec 2019

Retina-on-a-chip may provide useful alternative to existing models for studying eye disease

The development of a retina-on-a-chip, which combines living human cells with an artificial tissue-like system, has been described today in the open-access journal eLife.

27 Aug 2019

Artemisinins are still strongest weapon against malaria, say experts

The powerful medicines known as artemisinins have plenty of mileage in them in the global fight against malaria, and concern about partial resistance has been overstated.

26 Apr 2019

Researchers discover possible new therapeutic strategy for pancreatic cancer

Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers.

21 Mar 2019

Scientists develop novel way with genome sequences to study widespread form of malaria

Scientists at the Institute of Genome Sciences at the University of Maryland School of Medicine have developed a novel way with genome sequences to study and better understand transmission, treat and ultimately eradicate Plasmodium vivax, the most widespread form of malaria. P. vivax is a single-celled transmitted by mosquitoes.

11 Feb 2019

Researchers reveal brain mechanism that drives itch-evoked scratching behavior

It's a maddening cycle that has affected us all: it starts with an itch that triggers scratching, but scratching only makes the itchiness worse.

14 Dec 2018

Study identifies molecular switch that controls fate of milk-producing breast cells

A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

15 Oct 2018

Daily exercise facilitates elimination of toxic proteins from muscles

A study published in Scientific Reports by researchers at the University of São Paulo in Brazil, in partnership with colleagues in the United States and Norway, shows that the lack of muscle stimulus results in a buildup of inadequately processed proteins in muscle cells and consequently leads to muscle weakness or wasting.

27 Sep 2018

New malaria drug starts clinical trials

After decades a new drug against malaria has been developed and first clinical trials of this new investigational drug is soon to begin. Enrolment for the same has already started. This study is to be sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institutes of Health (NIH). It is to take place at the Duke University School of Medicine in Durham, North Carolina.

11 Sep 2018