Chromatin News and Research

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Combination therapy may reduce influenza-associated morbidity and mortality

A significant proportion of hospitalized patients with influenza develop complications of acute respiratory distress syndrome, driven by virus-induced cytopathic effects as well as exaggerated host immune response.

16 Mar 2021

Chromatin-regulating enzyme found to be a key driver of common lung cancer

A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer.

15 Mar 2021

Super-resolution system microscopy can reveal pluripotency and differentiation of live stem cells

A new super-resolution system microscopy can assess the pluripotency and differentiation of live stem cells, spearheading a new era in stem-cell research and systems biology.

9 Mar 2021

Understanding Absolute Stoichiometry of Oligomeric Protein Complexes Using SEC-MALS

News-Med interviews .... about using SEC-MALS to characterize the native oligomeric state of Nap proteins and their complexes.

24 Feb 2021

Scientists examine DNA repair pathways and their impact on cancer evolution

DNA repair pathways exist to correct molecular damage caused by internal and external factors. However, any damage to these pathways can result in the creation of tumors and specific types of cancers.

17 Feb 2021

Study shows how tissue damage promotes the earliest stages of pancreatic cancer

Like weeds sprouting from cracks in the pavement, cancer often forms in sites of tissue damage. That damage could be an infection, a physical wound, or some type of inflammation.

4 Feb 2021

CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases

CoCID (Compact Cell Imaging Device), a €5.7 million, four-year, pan-European research and innovation project, funded through Horizon 2020, has officially commenced.

2 Feb 2021

Plants depend on LEAFY protein that enables cells to change their fate

Cells don't express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn't need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.

28 Jan 2021

Researchers discover rare genetic disorder that affects the brain, heart and facial features

Researchers at the National Institutes of Health have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart and facial features.

20 Jan 2021

Computational method uses heat map data to reverse engineer 3D chromosome models

Genome analysis can provide information on genes and their location on a strand of DNA, but such analysis reveals little about their spatial location in relation to one another within chromosomes -- the highly complex, three-dimensional structures that hold genetic information.

15 Jan 2021

Medicinal plant-derived compound destroys brain-eating amoeba in lab studies

Primary amoebic meningoencephalitis (PAM), a deadly disease caused by the "brain-eating amoeba" Naegleria fowleri, is becoming more common in some areas of the world, and it has no effective treatment.

13 Jan 2021

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

11 Jan 2021

Researchers investigate prognostic role of diversity of chromatin compartments in gynecological cancers

A novel marker might contribute to selecting high-risk stage I ovarian carcinoma patients for adjuvant chemotherapy and low-risk endometrial carcinoma patients for less extensive surgery.

8 Jan 2021

Epigenetic modulators have a rapid antidepressant-like effect, study shows

Treatment of depression faces two main challenges. The first is that almost 50% of patients do not respond well to existing antidepressants.

4 Jan 2021

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell.

24 Dec 2020

Researchers establish BRIDGES program to synergize diagnostic efforts, patient outcome management

For over 20 years, the Genetics Service at the KK Women's and Children's Hospital (KKH) has been providing clinical care to patients with genetic disorders.

22 Dec 2020

New understanding of physical properties of chromatin may show how genome is encoded and decoded

University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid?

20 Dec 2020