Chromosome 12 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 12, one copy inherited from each parent, form one of the pairs. Chromosome 12 spans about 132 million DNA building blocks (base pairs) and represents between 4 percent and 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 12 likely contains between 1,200 and 1,400 genes.

Genes on chromosome 12 are among the estimated 20,000 to 25,000 total genes in the human genome.
Gene coding error likely responsible for rare form of inherited 'short telomere' disease

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

Study sheds light on emergence and spread of drug-resistant malaria parasites in Africa

Study sheds light on emergence and spread of drug-resistant malaria parasites in Africa

Study links high number of copies of chromosomal region to chemotherapeutic drug resistance

Study links high number of copies of chromosomal region to chemotherapeutic drug resistance

A love of coffee and tea is mostly genetic

A love of coffee and tea is mostly genetic

Breakthrough study sheds light on mechanism underlying Warsaw Breakage Syndrome

Breakthrough study sheds light on mechanism underlying Warsaw Breakage Syndrome

New findings refine link between clonal hematopoiesis and blood cancer risk

New findings refine link between clonal hematopoiesis and blood cancer risk

Scientists explore interactions between chromosomes 12 and 17

Scientists explore interactions between chromosomes 12 and 17

Anorexia nervosa linked to genetic anomalies on chromosome 12

Anorexia nervosa linked to genetic anomalies on chromosome 12

Study identifies first genetic locus for anorexia nervosa

Study identifies first genetic locus for anorexia nervosa

Scientists discover unique genomic changes integral to testicular cancer development

Scientists discover unique genomic changes integral to testicular cancer development

Scientists identify gene that causes hereditary hypertension and brachydactyly type E

Scientists identify gene that causes hereditary hypertension and brachydactyly type E

Genetic markers may help decide who benefits from aspirin, NSAIDs in lowering risk of colorectal cancer

Genetic markers may help decide who benefits from aspirin, NSAIDs in lowering risk of colorectal cancer

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

Dysregulation of CISTR-ACT causes brachydactyly type E

Dysregulation of CISTR-ACT causes brachydactyly type E

Two papers connect lncRNAs to inherited conditions in humans

Two papers connect lncRNAs to inherited conditions in humans

METASTROKE refines genetic stroke culprits

METASTROKE refines genetic stroke culprits

METASTROKE refines genetic stroke culprits

METASTROKE refines genetic stroke culprits

GUCY2C gene mutation leads to familial diarrhea syndrome

GUCY2C gene mutation leads to familial diarrhea syndrome

Genetic mutation linked to peripartum cardiomyopathy during pregnancy

Genetic mutation linked to peripartum cardiomyopathy during pregnancy

Scientists identify new risk gene variant for depression

Scientists identify new risk gene variant for depression