Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 11, one copy inherited from each parent, form one of the pairs. Chromosome 11 spans about 134 million DNA building blocks (base pairs) and represents between 4 percent and 4.5 percent of the total DNA in cells.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 11 likely contains about 1,500 genes. More than 150 of these genes provide instructions for making olfactory receptors, which are proteins that are used to detect different smells.
Genes on chromosome 11 are among the estimated 20,000 to 25,000 total genes in the human genome.
A brain chemical that plays a role in long term memory also appears to be involved in regulating how much people eat and their likelihood of becoming obese, according to a National Institutes of Health study of a rare genetic condition.
In two papers published today, deCODE scientists and academic colleagues from Europe and the U.S. expand upon the company's recent findings in the genetics of pigmentation traits in people of European descent, and demonstrate that certain of these common variants also confer risk of two types of skin cancer.
Researchers at Georgetown University Medical Center have found a small molecule they say can block the action of the oncogene that causes Ewing's sarcoma, a rare cancer found in children and young adults.
Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.
Their finding is the first to link individual differences written into the genetic code with a vaccine-related complication, albeit a mild one.
The study, published in the July 15th issue of The Journal of Infectious Diseases, now available online, may have implications for predicting adverse events from other live vaccines. .
Researchers have identified genetic markers on several chromosomes in the tissue surrounding tumor cells that are associated with breast cancer tumor grade and the presence of lymph node metastases, according to a study in the May 16 issue of JAMA.
Using an innovative statistical approach, a research team from Washington University School of Medicine in St. Louis and the University of California, Los Angeles, has identified two regions of DNA linked to autism.
The identification of a cluster of essential genes on mouse chromosome 11 as well as similar clusters on the chromosomes of other organisms , including humans , buttresses the argument that there may be rules as to how genes are structured or laid out on chromosomes, said the Baylor College of Medicine senior author of a report that appears online in the Public Library of Science Genetics, an open-access publication.
Ten genetic variants associated with type 2 diabetes, a disease which impacts more than 170 million people worldwide, have been identified or confirmed by a U.S.-Finnish team led by scientists at the University of Michigan School of Public Health.
In the most comprehensive look at genetic risk factors for type 2 diabetes to date, a U.S.-Finnish team, working in close collaboration with two other groups, has identified at least four new genetic variants associated with increased risk of diabetes and confirmed existence of another six.
Yale School of Medicine autism experts Fred Volkmar, M.D. and Ami Klin are part of a global research consortium from 19 countries to identify a gene and a region of a chromosome that may lead to autism in children.
The genomes of the largest collection of families with multiple cases of autism ever assembled have been scanned and the preliminary results published in Nature Genetics. They provide new insights into the genetic basis of autism.
An international team of scientists have discovered two new genetic links that may predispose children to develop autism.
Preliminary findings from the largest genome scan ever completed in the history of autism research are being published in Nature Genetics. University of Pittsburgh researchers with a consortium of scientists from across the world contributed to this landmark research endeavor through the Autism Genome Project.
Using molecular and cell-based models, researchers at Georgetown University Medical Center have refined the picture of how a cancer-promoting protein associated with Ewing's sarcoma functions.
Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.
A new study reports that a loss of genes on chromosome 1 or chromosome 11 raises the risk of death from the children's cancer neuroblastoma, even when other indicators seem to point to a lower-risk form of the disease.
Johns Hopkins Kimmel Cancer Center researchers have linked alterations in a gene, called Rsf-1, to the most deadly ovarian cancers. The scientists say the discovery is the first to establish a role for the gene in ovarian cancer and may lead to a test that can predict, early on, which patients will develop aggressive disease.
Rather than covering the entire genome, the microarray focuses on suspect regions of chromosomes for signs of deleted genetic material known to play a role in the cancer.