Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

One in 500 men may carry an extra X or Y chromosome which could increase risk of several diseases

Around one in 500 men could be carrying an extra X or Y chromosome – most of them unaware – putting them at increased risk of diseases such as type 2 diabetes, atherosclerosis and thrombosis, say researchers at the universities of Cambridge and Exeter.

10 Jun 2022

Researchers create first comprehensive functional map of genes expressed in human cells

The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including Whitehead Institute, and was finally completed in 2003.

9 Jun 2022

Research suggests two protein coding genes can predict severe COVID-19

In a recent study posted to the medRxiv* pre-print server, researchers demonstrated that two genes, GTPase, IMAP Family Member 7 (GIMAP7), and sphingosine-1-phosphate receptor 2 (S1PR2), have the potential to predict severe coronavirus disease 2019 (COVID-19) with ~90% accuracy.

8 Jun 2022

Sarbecovirus pathogenesis regulated by a multitrait locus

In a recent study posted to the bioRxiv* preprint server, the authors demonstrated that the sarbecovirus pathogenesis was regulated by a multitrait locus.

7 Jun 2022

Potential new diagnostic marker predicts successful, efficient development of mammalian egg cells

Researchers at the Centre for Genomic Regulation in Barcelona have identified a potential new diagnostic marker that predicts the successful and efficient development of mammalian egg cells.

23 May 2022

Deep visual proteomics is redefining cancer diagnostics

In a recent study published in the journal Nature Biotechnology, researchers introduced deep visual proteomics (DVP), an amalgamation of artificial intelligence (AI) for image analysis and mass spectrometry (MS) for proteomic profiling of biological samples.

22 May 2022

The link between androgens and COVID-19

A new paper examines the association between androgens and COVID-19, as revealed by the research carried out on this topic throughout the pandemic.

20 May 2022

New study reveals the genetic mechanism behind severe staphylococcal infections

A common culprit of skin and respiratory infections, Staphylococcus aureus is highly unpredictable. Between 20 and 30 percent of people carry quiet colonies on their skin and in their nostrils, which seldom cause problems beyond the occasional rash.

19 May 2022

COVID-19 mortality strongly predicted by autoimmunity to type I interferons and advancing age

In a recent study published in the journal PNAS, researchers estimated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) and relative risk of death (RRD) among subjects across ages.

19 May 2022

Camelid IFNs could play important role in combating emerging zoonotic pathogens

In a recent study published in the Developmental & Comparative Immunology journal, the discovery of a novel form of mammalian interferon-Beta (IFN-β) with four cysteine residues from the dromedary camel and the five remaining members of the mammalian suborder Tylopoda is described.

17 May 2022

UC Davis researchers identify a protein that keeps Kaposi's sarcoma-associated herpesvirus dormant

A team of UC Davis researchers has identified a protein in the cancer cell's nucleus as a critical agent keeping Kaposi's sarcoma-associated herpesvirus (KSHV) dormant and undetected by the body's immune system.

11 May 2022

Researchers find gene that shapes mutation rate in mice

Every organism is born with a few mutations in their genome that differ genetically from both of their parents.

11 May 2022

Deep learning reveals genetic determinants of COVID-19-associated mortality

In a recent study posted to the medRxiv* preprint server, researchers applied deep learning methods and identified genetic variants linked to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-caused mortality.

11 May 2022

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

An article published in the journal Molecular Psychiatry reveals the molecular mechanisms to explain how the YWHAZ gene –related to psychiatric and neurological disorders such as autism and schizophrenia– can alter the neurodevelopmental process.

10 May 2022

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities.

9 May 2022

New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Researchers at Children's Hospital of Philadelphia have developed a new tool to help researchers interpret the clinical significance of somatic mutations in cancer.

6 May 2022

Scientists investigate the association between walking pace and leucocyte telomere length

In a new study, scientists investigated the association between walking pace and leucocyte telomere length.

5 May 2022

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

A recent study published in the journal Immunology analyzed whether sex mattered in the immune response to SARS-CoV-2.

29 Apr 2022

DGP student investigates sexual dysmorphism in mice

Isabella Salamone is an eighth-year student in the Driskill Graduate Program in Life Sciences (DGP) who is studying sexual dysmorphism in mice in the laboratory of Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine.

28 Apr 2022

Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

Chromosome 4 News and Research

Further Reading

One in 500 men may carry an extra X or Y chromosome which could increase risk of several diseases

Researchers create first comprehensive functional map of genes expressed in human cells

Research suggests two protein coding genes can predict severe COVID-19

Sarbecovirus pathogenesis regulated by a multitrait locus

Potential new diagnostic marker predicts successful, efficient development of mammalian egg cells

Deep visual proteomics is redefining cancer diagnostics

The link between androgens and COVID-19

New study reveals the genetic mechanism behind severe staphylococcal infections

COVID-19 mortality strongly predicted by autoimmunity to type I interferons and advancing age

Camelid IFNs could play important role in combating emerging zoonotic pathogens

UC Davis researchers identify a protein that keeps Kaposi's sarcoma-associated herpesvirus dormant

Researchers find gene that shapes mutation rate in mice

Deep learning reveals genetic determinants of COVID-19-associated mortality

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Scientists investigate the association between walking pace and leucocyte telomere length

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

DGP student investigates sexual dysmorphism in mice

Genetic cause of lupus identified

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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