Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 8, one copy inherited from each parent, form one of the pairs. Chromosome 8 spans about 146 million DNA building blocks (base pairs) and represents between 4.5 percent and 5 percent of the total DNA in cells.
Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 8 likely contains between 700 and 1,100 genes.
Genes on chromosome 8 are among the estimated 20,000 to 25,000 total genes in the human genome.
A new study published on the preprint server medRxiv in June 2020 shows that variants in the ACE2 gene which encodes the enzyme receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease, are linked to the risk of severe disease.
Blood type may play a pivotal role in driving disease severity among coronavirus disease (COVID-19) patients. Genetic analysis of COVID-19 patients has shown that people with blood type O seemed to be protected against severe disease. In contrast, those with blood type A may experience complications tied to the viral infection.
Scientists at the Stowers Institute for Medical Research have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models of Cornelia de Lange syndrome.
Researchers at Massachusetts General Hospital have identified a key mechanism in X chromosome inactivation, a phenomenon that may hold clues that lead to treatments for certain rare congenital disorders.
A study by the Centre for Chromosome Biology at NUI Galway, Ireland, in partnership with the University of Zurich, has uncovered new insights into how the replication of DNA occurs which can be applied to help develop novel cancer treatments.
Knowing what cancer will do next could lessen the likelihood of it becoming resistant to treatment. A new Canadian study investigates how cancer adapts its metabolism to potentially overcome therapies still in development.
New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells--including cancer cells--regulate their genes.
In their recent paper released on the bioRxiv preprint server, a research group from Spain demonstrated how genome changes and deletions in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could represent a strategy of natural selection used for lessening the impact of infection in order to increase viral transmission potential.
In the famous words of movie character Forrest Gump, "Life is like a box of chocolates; you never know what you're gonna get."
A new study published in June 2020 on the preprint online server medRxiv reports on the increased risk of COVID-19 in Down Syndrome (DS) and certain characteristic features that are found in this population segment.
A group of over 120 researchers from various institutions across Europe has performed the first genome-wide association study to reveal host genetic factors that may contribute to respiratory failure in cases of coronavirus disease 209 (COVID-19).
Researchers at the Francis Crick Institute, the Institut Pasteur and their clinical collaborators have identified a cause of testicular tissue developing in people with female chromosomes.
From bacteria-made insulin that obviates the use of animal pancreases to a better understanding of infectious diseases and improved treatments, genetic engineering of bacteria has redefined modern medicine. Yet, serious limitations remain that hamper| progress in numerous other areas.
The targeted therapy pralsetinib appears to have high response rates and durable activity in patients with a broad variety of tumors harboring RET gene fusions, according to results from the international Phase I/II ARROW trial, led by researchers at The University of Texas MD Anderson Cancer Center.
As chromosomes go, X and Y make an unlikely pair. The X is large and contains thousands of genes critical for life. The Y, by contrast, is little more than a nub.
A mouse model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduces features observed in human patients, researchers report May 26 in the journal Cell Host & Microbe.
Researchers from the group of Hans Clevers at the Hubrecht Institute have modeled the development and progression of high-grade serous ovarian cancer in mini-versions of the female reproductive organs of the mouse.
Researchers at Karolinska Institutet in Sweden have developed a new sequencing method that makes it possible to map how DNA is spatially organised in the cell nucleus - revealing which genomic regions are at higher risk of mutation and DNA damage.
The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants.
A Monash University study has uncovered the role DNA repair plays in preserving egg quality, offering hope for women whose eggs may be damaged through treatments such as radiation and chemotherapy.