Chronic Lymphocytic Leukemia News and Research

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Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia in adults. According to the American Cancer Society, approximately 8,000 patients will be diagnosed this year. More than 60,000 people in the U.S. currently have CLL. The disease arises in lymphocytes, a type of white blood cell that normally produces antibodies and serves important immune functions.

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

New findings by Yale Cancer Center and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia, so do the rates of patients who stop taking the drug.

9 Dec 2019

Thermo Fisher Scientific to accelerate genomic profiling process in hematology and oncology labs

Clinical researchers who take a traditional sequential approach to analyze myeloid malignancies, a highly heterogeneous group of disorders, face a major hurdle: a laborious and time-consuming workflow.

From Thermo Fisher Scientific Inc. 9 Dec 2019

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912.

8 Dec 2019

FDA approves Ohio State-developed drug to treat patients with CLL and SCL

On Nov. 21, 2019, the U.S. Food and Drug Administration approved the use of the drug acalabrutinib for first-line therapy in chronic lymphocytic leukemia and small cell lymphoma.

22 Nov 2019

Cancer drug shows promise in treating metabolic syndrome

Metabolic syndrome is a group of health problems characterized by the presence of elevated blood pressure, increased levels of triglycerides, high blood sugar, excess body fat around the waist, and obesity. If it’s left untreated, it can increase the risk of heart disease, stroke, and type 2 diabetes. Usually, treating metabolic syndrome involves targeting individual risk factors and modifying lifestyle practices.

18 Nov 2019

Rutgers researcher receives $600,000 grant to study chronic lymphocytic leukemia

Rutgers Cancer Institute of New Jersey researcher Hossein Khiabanian, PhD, has received a $600,000 Translational Award from the V Foundation for Cancer Research to study chronic lymphocytic leukemia with the aim of developing research models that may help investigators better understand how CLL cells are influenced by new therapies.

11 Nov 2019

MD Anderson and Takeda announce agreement to develop off-the-shelf CAR NK-cell therapy platform

The University of Texas MD Anderson Cancer Center and Takeda Pharmaceutical Company Limited today announced an exclusive license agreement and research agreement to develop cord blood-derived chimeric antigen receptor-directed natural killer (CAR NK)-cell therapies, 'armored' with IL-15, for the treatment of B-cell malignancies and other cancers.

5 Nov 2019

Scientists harness the power of immune system to test novel cancer treatment

The field of immunotherapy has revolutionized the way people with incurable cancers are treated, saving the lives of many people whose disease would have otherwise been seen as a death sentence. Despite its success in treating people with deadly forms of leukemia and lymphoma, there are still many people who do not benefit from the treatment or eventually experience a relapse of their cancer.

16 Oct 2019

Novel cancer-driving mutation discovered in vast non-coding regions of the cancer genome

An Ontario-led research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the "dark matter" of human cancer DNA.

9 Oct 2019

Researchers discover metabolic vulnerability in cancer cells with mutated spliceosomes

A research team from the Johns Hopkins Kimmel Cancer Center reports it has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.

From Johns Hopkins Medicine 3 Oct 2019

Leukemia is not just one disease

An estimated 61,780 new cases of leukemia will be diagnosed in the United States this year, with some 2,000 cases in New Jersey, according to the American Cancer Society.

30 Aug 2019

People who have a parent, sibling, or child with blood cancer have higher risk of disease

New data suggest that people who have a parent, sibling, or child with blood cancer have a higher likelihood of being diagnosed with the disease.

9 Aug 2019

New leukemia treatment developed from common wild flower

Researchers have discovered how to turn a compound from a common wildflower called Feverfew into a new treatment for leukemia.

1 Aug 2019

New tool reveals how genes interact to form tissues and organisms

Although the knowledge we have about human cells and tissues has steadily increased over recent decades, many things remain unknown.

4 Jun 2019

Combination treatment effective as front-line therapy for select chronic lymphocytic leukemia patients

Ibrutinib and venetoclax, two FDA-approved drugs for treating chronic lymphocytic leukemia, have been shown to be effective when given together for high-risk and older patients with the disease, according to a study at The University of Texas MD Anderson Cancer Center.

30 May 2019

Study identifies patterns of chronic lymphocytic leukemia growth

In patients with chronic lymphocytic leukemia, the rate of disease growth is apt to follow one of three trajectories: relentlessly upward, steadily level, or something in between, scientists at Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and the University of Washington report in a new study.

29 May 2019

Researchers identify why lymphoma patients may become resistant to specific drug

With more targeted therapies being approved each year for cancer, the development of drug resistance to these agents is a growing concern.

16 May 2019

New test could be a ‘game changer’ in the treatment of chronic lymphocytic leukemia

The first test to quickly and accurately predict how people will respond to standard treatment for the most common type of leukemia has been developed at Cardiff University. The technology could guide doctors’ decisions on which drugs to give to patients.

27 Feb 2019

EU-funded project investigates molecular mechanisms of aging in adult stem cells

Stem cells are the ultimate mother cells of the human body. Not only do they have the capacity to self-renew, they can develop into specific cell types as the body requires. But as the human body ages, the regenerative capacity of our stem cells diminishes.

8 Feb 2019

New approach identifies epigenetic changes in leukemia cells for patients undergoing ibrutinib treatment

Many new anti-cancer drugs inhibit proteins that are essential for the proliferation of cancer cells. One example is ibrutinib, an innovative therapy for chronic lymphocytic leukemia first approved in 2014.

29 Jan 2019