Cirrhosis is a condition in which the liver slowly deteriorates and malfunctions due to chronic injury. Scar tissue replaces healthy liver tissue, partially blocking the flow of blood through the liver. Scarring also impairs the liver’s ability to control infections, remove bacteria and toxins from the blood, process nutrients, hormones and drugs, make proteins that regulate blood clotting and produce bile to help absorb fats—including cholesterol—and fat-soluble vitamins.
Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.
Shionogi & Co., Ltd. announced today that Mulpleta (lusutrombopag), a once-daily, orally administered, small molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled to undergo a procedure, is now available throughout the United States.
Routine oral care to treat gum disease may play a role in reducing inflammation and toxins in the blood and improving cognitive function in people with liver cirrhosis.
Pulmonary fibrosis is one of the most common and serious types of lung disease. Now NIBIB-funded researchers have developed an in vitro lung tissue-on-a-chip system that mimics lung fibrosis, offering rapid testing of potential new anti-fibrotic treatments.
Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report.
Since the first liver transplant in 1963, donated livers have been immersed in an icy cold fluid in a cold storage system for transport, similar in principle to ice chests used for picnics and trips to the beach.
A team of researchers from the School of Immunology and Microbial Sciences and the Dental Institute has secured a multi-million Euro award to conduct research into liver disease.
The U.S. Food and Drug Administration today approved Annovera (segesterone acetate and ethinyl estradiol vaginal system), which is a combined hormonal contraceptive for women of reproductive age used to prevent pregnancy and is the first vaginal ring contraceptive that can be used for an entire year.
genedrive plc, a near patient molecular diagnostics company, and the Foundation for Innovation of New Diagnostics (FIND), announced today a study agreement for the performance evaluation of genedrive plc’s hepatitis C virus (HCV) Genedrive HCV ID Kit.
Johns Hopkins scientists report they have identified two potential new drug targets for the treatment of HIV. The finding is from results of a small, preliminary study of 19 people infected with both HIV-;the virus that causes AIDS-;and the hepatitis C virus.
A new study has shown that genetic variation may increase the risk of severe liver damage in Caucasians with chronic hepatitis B infection.
According to the Centers for Disease Control and Prevention, 300 million people across the globe are unaware they're living with viral hepatitis. In fact, baby boomers-;those born between 1945-1965-;are five times more likely to have hepatitis C, one of the many different strains of this viral infection.
Bile acids that aid fat digestion are also found to reduce the rewarding properties of cocaine use, according to a study publishing on July 26 in the open-access journal PLOS Biology by India Reddy, Nicholas Smith, and Robb Flynn of Vanderbilt University, Aurelio Galli of the University of Alabama at Birmingham, and colleagues.
DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But sometimes this process goes awry.
Deaths from cirrhosis rose in all but one state between 1999-2016, with increases seen most often among young adults, a new study shows.
In an Addiction Biology study, the estimated prevalence of very high risk drinking level (VHRDL, defined as drinking >100 g of ethanol per day) in 13 European Union countries was 0.74-0.85 percent, with a risk of disease or injury of 13.5 per 100 people with VHRDL per year.
Normal scar tissue forms to heal an internal wound and quietly retreats when the job is done. But in many common diseases - kidney, liver and lung fibrosis -- the scar tissue goes rogue and strangles vital organs. These diseases are largely untreatable and ultimately fatal.
Among the most serious consequences of the opioid epidemic is the spread of hepatitis C among injecting drug users.
One of the lines of research of the UPV/EHU's Lipids & Liver group, which focusses on the mechanisms involved in the development and progression of non-alcoholic fatty liver disease, is achieving significant advances in a range of aspects; these include the identification of proteins that alter the metabolic pathways in the development and progression of liver disease, and even cancer, and the seeking of targets to enable the disease to be reversed.
A simple $20 blood test could help diagnose thousands of patients with hepatitis B in need of treatment in some of Africa's poorest regions.