Cirrhosis is a condition in which the liver slowly deteriorates and malfunctions due to chronic injury. Scar tissue replaces healthy liver tissue, partially blocking the flow of blood through the liver. Scarring also impairs the liver’s ability to control infections, remove bacteria and toxins from the blood, process nutrients, hormones and drugs, make proteins that regulate blood clotting and produce bile to help absorb fats—including cholesterol—and fat-soluble vitamins.
A treatment gap remains for many conditions involving damage to the liver, the body's main organ for removing toxins, among other functions. The Experimental Biology 2018 meeting (EB 2018) will feature important research announcements related to the causes of liver degradation and possible treatments.
A single treatment using an optimized, targeted form of faecal microbiota transplantation (FMT) produces sustained clinical and cognitive improvements, according to the results of a long-term follow-up of patients with liver cirrhosis and hepatic encephalopathy (HE) who had participated in a short-term study.
The first results from the POISE biopsy sub-study have today confirmed that long-term treatment with obeticholic acid leads to the reversal or stabilization of fibrosis/cirrhosis in patients with primary biliary cholangitis who have had an incomplete response to ursodeoxycholic acid.
The final results of the palliative cohort of the SORAMIC study in patients with unresectable, locally advanced primary liver cancer have confirmed no clinical advantage to adding selective internal radiation therapy to standard sorafenib treatment compared with using sorafenib alone.
A worldwide study initiated to investigate the epidemiology and outcomes of bacterial infections in hospitalized patients with liver cirrhosis has reported a prevalence of multi-drug-resistant bacteria of 34% and significant regional differences in the risk of developing a multi-drug-resistant infection.
Chronic hepatitis B virus (HBV) can progress to cirrhosis and hepatocellular carcinoma (HCC). A study published in The Journal of Molecular Diagnostics describes a new HBV assay that offers advantages over currently used methods because it has the capability to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples.
A diet that is Mediterranean style, and rich in vegetables and fermented milk products such as yoghurt, along with coffee, tea and chocolate, is associated with greater gut microbial diversity and a lower risk of hospitalization in patients with liver cirrhosis, according to the results of an international study presented today at The International Liver Congress™ 2018 in Paris, France.
An animated short-film produced by the ALIVER consortium titled "Life After Liver Failure", premieres tomorrow morning at the BioTech Village in The International Liver Congress 2018.
Kandice Fogle, 43, had just moved to Houston when she began experiencing pain in her back and groin. After undergoing a CT scan, doctors found a large mass in her liver. A biopsy confirmed that she had intrahepatic cholangiocarcinoma, more commonly known as bile duct cancer.
One of the major challenges identified by the WHO in efforts to eradicate the hepatitis C virus (HCV) is the diagnosis of chronic cases that are generally asymptomatic.
A poor diet and other risk factors can result in liver disease. This important metabolic organ can become fatty and inflamed. In the long term, this may result in irreversible and life-threatening organ damage (cirrhosis of the liver or 'shrunken liver').
The microbiome is the collection of microorganisms that colonize the human body. Dr. Jasmohan Bajaj discusses the relationship between the microorganisms in the gut and cirrhosis, and how microbiome analysis can be used to predict the risk of cirrhosis-associated hospitalizations.
Obesity may adversely affect liver health in children as young as 8 years old, according to a new study led by researchers at Columbia University Medical Center.
A new study published today in The Journal of Pediatrics is the first to show that weight gain may have a negative impact on liver health in children as young as 8 years old. The study found that bigger waist circumference at age 3 raises the likelihood that by age 8, children will have markers for nonalcoholic fatty liver disease.
The gut microbiome -- a collection of bacteria and other microbes in the gut -- could be a highly accurate predictor of hospitalizations for patients with cirrhosis, according to a recently published study led by a researcher at Virginia Commonwealth University.
A new study indicates that patients with alcohol-related liver cancer often do not live as long as patients with liver cancer that is not associated with alcohol consumption, mainly due to diagnoses at later stages.
Sébastien Février, reader at the University of Limoges and researcher at XLIM, and his team demonstrated that a bench-top, optical fiber-based laser source can be used to perform infrared spectromicroscopy with a precision rivaling, and in some regards even surpassing, that of experiments at large-scale synchrotron facilities.
A report that Americans are drinking a lot of coffee might be good news in the battle against colon cancer, scientists with the Simmons Cancer Center at UT Southwestern Medical Center say.
In people with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is common and can progress to a severe liver disease known as nonalcoholic steatohepatitis (NASH).
A clinical study coordinated by the French National Research Institute for Sustainable Development and Chiang Mai University with their Thai, American, and French partners, strengthens the case for a new strategy to prevent mother-to-child transmission of the hepatitis B virus.