Clinical Depression News and Research

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Two-drug combination relieves depression in older adults

More than half of older adults with clinical depression don't get better when treated with an antidepressant. But results from a multicenter clinical trial that included Washington University School of Medicine in St. Louis indicates that adding a second drug — an antipsychotic medication — to the treatment regimen helps many of those patients.

28 Sep 2015

People with specific genotype are more deeply affected by life experiences, reveals study

People with a certain type of gene are more deeply affected by their life experiences, a new study has revealed.

23 Sep 2015

Women who become mothers following fertility treatment face increased risk of depression

Women giving birth after undergoing fertility treatment face an increased risk of depression compared to women ending up not having a child following fertility treatment, according to new research from the University of Copenhagen. According to the researchers, this has key implications for fertility treatment in future.

19 Aug 2015

Prion protein could play a role in depression

The discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of depression, known as the monoamine hypothesis. This hypothesis proposes that an imbalance of certain brain chemicals is the key cause of depression.

14 Aug 2015

DISC-1: schizophrenia's "Rosetta Stone" gene? An interview with Professor Kevin Fox

The DISC-1 gene has been studied intensively over the years because people with mutations in DISC1 have a high likelihood of mental illness. DISC-1 was known to be associated with schizophrenia, bipolar disorder, major clinical depression and autism.

10 Aug 2015

Study: Unsuccessful fertility treatment not linked with increased risk of clinically diagnosed depression in women

An analysis of data on more than 41,000 Danish women who received assisted reproductive fertility treatment shows that unsuccessful treatment is not linked with an increased risk of clinically diagnosed depression compared with successful treatment.

4 Aug 2015

Breakthrough reveals influence of schizophrenia’s 'Rosetta Stone' gene in brain development

Scientists have identified a critical function of what they believe to be schizophrenia's "Rosetta Stone" gene that could hold the key to decoding the function of all genes involved in the disease.

24 Jul 2015

Person-centered approach to physical therapy has positive effect on depression

Exercise has a positive effect on depression - so reveals a dissertation written at the Sahlgrenska Academy. In at study at the Sahlgrenska Academy, the researcher evaluated exercise as add-on therapy to medicating with antidepressants. The study divided 62 individuals with diagnosed clinical depression into three groups, in which two participated in two different types of exercise with a physiotherapist twice a week for 10 weeks while the third, the control group, did not participate in systematic exercise.

12 Jun 2015

Greater evidence-based help needed for depressed workers - New report from The Work Foundation

A report from Lancaster University’s Work Foundation recommends that in order to improve both productivity and health and wellbeing among those of working age, more concerted action must be taken to support people with depression to stay in and to return to work...

21 May 2015

OSU researchers find link between low levels of vitamin D and depression in young women

A new study from Oregon State University suggests there is a relationship between low levels of vitamin D and depression in otherwise healthy young women.

19 Mar 2015

Mice genetically deficient in serotonin are more vulnerable to social stressors

Mice genetically deficient in serotonin -- a crucial brain chemical implicated in clinical depression -- are more vulnerable than their normal littermates to social stressors, according to a Duke study appearing this week in the Proceedings of the National Academy of Sciences.

10 Feb 2015

Brain scans can predict therapeutic responses to talk therapy

UNC School of Medicine researchers have shown that brain scans can predict which patients with clinical depression are most likely to benefit from a specific kind of talk therapy.

4 Feb 2015

Brain inflammation linked to clinical depression

A new study by the Centre for Addiction and Mental Health found that the measure of brain inflammation in people who were experiencing clinical depression was increased by 30 per cent. The findings, published today in JAMA Psychiatry, have important implications for developing new treatments for depression.

28 Jan 2015

Research findings may lead to new treatment for hypothyroidism

An international research team led by physician-scientists at Rush University Medical Center have gained new insights into hypothyroidism - a condition affecting about 10 million people in the U.S. - that may lead to new treatment protocols for the disease, particularly among the approximately 15 percent of patients for whom standard treatments are less effective.

14 Jan 2015

Laughing gas could be used as treatment for severe depression

Nitrous oxide, or laughing gas, has shown early promise as a potential treatment for severe depression in patients whose symptoms don't respond to standard therapies. The pilot study, at Washington University School of Medicine in St. Louis, is believed to be the first research in which patients with depression were given laughing gas.

10 Dec 2014

Pathological guilt in preschool years linked to brain changes, increases risk for recurrent depression

In school-age children previously diagnosed with depression as preschoolers, a key brain region involved in emotion is smaller than in their peers who were not depressed, scientists have shown.

14 Nov 2014

Anxiety can accelerate conversion to Alzheimer's disease for people with mild cognitive impairment

People with mild cognitive impairment (MCI) are at increased risk of converting to Alzheimer's disease within a few years, but a new study warns the risk increases significantly if they suffer from anxiety.

11 Nov 2014

Scientists alter emotional associations of specific memories

By manipulating neural circuits in the brain of mice, scientists have altered the emotional associations of specific memories.

28 Aug 2014

Study confirms close link between immune system and adult neurogenesis

A new study by Barbara Beltz, the Allene Lummis Russell Professor of Neuroscience at Wellesley College, and Irene Soderhall of Uppsala University, Sweden, published in the August 11 issue of the journal Developmental Cell, demonstrates that the immune system can produce cells with stem cell properties, using crayfish as a model system. These cells can, in turn, create neurons in the adult animal.

19 Aug 2014

Weight loss improves physical health, but takes toll on mental health

Weight loss significantly improves physical health but effects on mental health are less straightforward, finds new UCL research funded by Cancer Research UK.

7 Aug 2014