Clinical Trial News and Research

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Virotherapy treatment kills prostate cancer cells

A new study appearing in The Prostate has found that certain measles virus vaccine strain derivatives, including a strain known as MV-CEA, may prove to be an effective treatment for patients with advanced prostate cancer.

21 Jan 2009

Impaired kidney function raises risk of heart problems in the elderly

A study published next week in the open access journal PLoS Medicine suggests that elderly people with damaged kidneys are at greater risk of cardiovascular disease, such as heart failure and stroke, and other causes of mortality.

21 Jan 2009

Measurement of kidney function in children with kidney disease improved

A formula used to measure kidney function in children with chronic kidney disease has been revised to make it more precise, according to a study published today in the Journal of the American Society of Nephrology.

21 Jan 2009

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result, according to a report in the January issue of Archives of Dermatology.

19 Jan 2009

Depressed adolescents not harmed by being part of placebo group in clinical trial

In a national clinical trial, adolescents with moderate to severe depression first given a placebo treatment and then an antidepressant medication alone or in combination with therapy responded just as well over the long term as participants who received active treatment throughout the study, UT Southwestern Medical Center researchers report.

19 Jan 2009

FDA issues complete response letter for SAPHRIS (asenapine) sublingual tablets in acute treatment of schizophrenia and bipolar disorder

Schering-Plough Corporation has announced that the U.S. Food and Drug Administration (FDA) has issued a complete response letter for SAPHRIS (asenapine) sublingual tablets in the acute treatment of schizophrenia in adults and in the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults as monotherapy.

15 Jan 2009

Probiotics prevent IgE-associated allergy until age 5 in cesarean-delivered children but not in total cohort

According to a recent study from the University and the University Central Hospital of Helsinki, Finland, no allergy-preventive effect is extended to age 5 years by perinatal supplementation with probiotics in babies at risk for developing allergies; protection is conferred only to Cesarean section babies.

15 Jan 2009

Advaxis wins European patent case involving Lovaxin-C vaccine

The European Patent Court in Munich, Germany has ruled in favor of Advaxis Incorporated and reversed a patent challenge made by Anza Therapeutics, Inc., formerly Cerus Corp.

15 Jan 2009

Treadmill exercise improves walking endurance for patients with PAD

Patients with peripheral arterial disease (PAD), which can include symptoms such as pain in the legs, who participated in supervised treadmill exercise improved their walking endurance and quality of life, according to a study in the January 14 issue of JAMA.

14 Jan 2009

Numerical analysis estimates numbers of older US adults who may benefit from statin therapy

Researchers estimate more than 11 million older Americans may be newly eligible for statin therapy if findings from a recently published large clinical trial are adopted into clinical practice guidelines, according to a new analysis of the trial data.

13 Jan 2009

Question marks over herbal remedies for menopausal symptoms

There is no strong evidence either way for several herbal remedies commonly taken to relieve troublesome menopausal symptoms, concludes the January issue of the Drug and Therapeutics Bulletin ( DTB ).

13 Jan 2009

Gene therapy kills brain tumors through selective recruitment of immune cells

Scientists seeking to harness the power of the immune system to eradicate brain tumors face two major hurdles: recruiting key immune cells called dendritic cells into areas of the brain where they are not naturally found and helping them recognize tumor cells as targets for attack.

13 Jan 2009

Novel low-cost immunotherapy for cancer cells

Molecules of sugar sitting on the surface of cancer cells are keys to the development of a new vaccine aimed at both treating and stopping the spread of certain types of cancers called carcinomas, which include prostate, breast, ovarian and lung, among others.

8 Jan 2009

New cataract early detection device

A compact fiber-optic probe developed for the space program has now proven valuable for patients in the clinic as the first non-invasive early detection device for cataracts, the leading cause of vision loss worldwide.

8 Jan 2009

Osteotech starts trial for DuraTech BioRegeneration Matrix

Osteotech, Inc. announced today that it has initiated a pivotal clinical trial for its DuraTech BioRegeneration Matrix.

7 Jan 2009

SpectraScience awarded U.S. patent for methods and apparatus for evaluating image focus

SpectraScience, Inc. has announced that it has been awarded U.S. Patent number 7,469,160 for its methods and apparatus for evaluating image focus.

6 Jan 2009

Sequella, Inc. drug compound SQ109 selected for phase 1B clinical trial program

Sequella, Inc., a clinical-stage biopharmaceutical company focused on diseases of epidemic potential, announced today that SQ109, its lead drug candidate for the treatment of tuberculosis (TB), was the first drug approved for evaluation in a newly awarded clinical program contract to Dynport Vaccine Company LLC and Quintiles Transnational.

6 Jan 2009

Chimerix completes phase I study and starts phase II multi-dose trial for CMX001

Chimerix, Inc., a biotechnology company developing orally available antiviral therapeutics, has announced that the Company has completed a single and multi-dose Phase I study of CMX001 in healthy volunteers.

6 Jan 2009

Researchers gain new insight into cancer metastasis

Few things are as tiresome as house hunting and moving. Unfortunately, metastatic cancer cells have the relocation process down pat. Tripping nimbly from one abode to another, these migrating cancer cells often prove far more deadly than the original tumor.

5 Jan 2009

Phase 3 trial begins for Gammagard liquid plus rHuPH20 in primary immunodeficiency patients

Baxter International Inc. and Halozyme Therapeutics, Inc. gas announced the start of a Phase 3 clinical trial of Baxter's Gammagard Liquid [Immune Globulin Intravenous] 10% (IGIV), marketed as KIOVIG in the European Union, with Halozyme's recombinant human hyaluronidase enzyme (rHuPH20, Enhanze Technology) for the treatment of primary immunodeficiency (PID).

From Baxter International Inc. 5 Jan 2009

Clinical Trial News and Research

Virotherapy treatment kills prostate cancer cells

Impaired kidney function raises risk of heart problems in the elderly

Measurement of kidney function in children with kidney disease improved

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Depressed adolescents not harmed by being part of placebo group in clinical trial

FDA issues complete response letter for SAPHRIS (asenapine) sublingual tablets in acute treatment of schizophrenia and bipolar disorder

Probiotics prevent IgE-associated allergy until age 5 in cesarean-delivered children but not in total cohort

Advaxis wins European patent case involving Lovaxin-C vaccine

Treadmill exercise improves walking endurance for patients with PAD

Numerical analysis estimates numbers of older US adults who may benefit from statin therapy

Question marks over herbal remedies for menopausal symptoms

Gene therapy kills brain tumors through selective recruitment of immune cells

Novel low-cost immunotherapy for cancer cells

New cataract early detection device

Osteotech starts trial for DuraTech BioRegeneration Matrix

SpectraScience awarded U.S. patent for methods and apparatus for evaluating image focus

Sequella, Inc. drug compound SQ109 selected for phase 1B clinical trial program

Chimerix completes phase I study and starts phase II multi-dose trial for CMX001

Researchers gain new insight into cancer metastasis

Phase 3 trial begins for Gammagard liquid plus rHuPH20 in primary immunodeficiency patients

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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