Clostridium News and Research

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Gene technology to fight Clostridium difficile

Scientists at The University of Nottingham are leading a major European study to unravel the genetic code of one of the most lethal strains of hospital acquired infections.

19 Jan 2009

New nasal spray vaccine shown to be effective against botulism

A preclinical study found a new nasal spray vaccine to provide complete protection against a major botulism toxin, according to a study published today in the Nature journal Gene Therapy .

8 Jan 2009

New report shows high Clostridium difficile infection rates in U.S. hospitals

Consumers Union called on hospitals today to take more aggressive steps to protect patients from Clostridium difficile (C.-diff.) infections in light of a new report showing that they are much more common than previous estimates had indicated. As the rate of hospital acquired C.-diff. infections has jumped in recent years, an increasing number of patients have developed antibiotic-resistant strains of the infection that are more difficult to treat and more deadly.

11 Nov 2008

Phase 2 trial of treatment of C-difficile-associated diarrhea shows promise

Medarex, Inc. and The Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) today announced that a Phase 2 trial of an anti- C. difficile antibody combination treatment in patients with C.

4 Nov 2008

Current hospital tests for Clostridium difficile not accurate enough

Current hospital tests for the bacterium Clostridium difficile (C difficile) are not accurate enough and a new two-stage process should be introduced to avoid misdiagnosis and its consequences.

2 Nov 2008

Targanta Therapeutics presents preclinical data on Oritavancin against Clostridium difficile infection

Targanta Therapeutics Corporation has released the in vivo data from a preclinical study comparing the activity of its antibiotic drug candidate, oritavancin, to vancomycin in a hamster model of Clostridium difficile infection.

26 Oct 2008

Maggots the key to fighting superbugs

Scientists at Swansea University in Wales have discovered that maggots may hold the key to fighting superbugs.

5 Aug 2008

Superbug breakthrough

The week the government's chief medical officer for England, Sir Liam Donaldson, has announced that the NHS aims to create immunisation against two of the most common superbugs, MRSA and Clostridium difficile, within the next decade. But a research team led by University of Sunderland scientists has made a major breakthrough in the fight against a deadly hospital infection which kills tens of thousands of people every year, and it will be available within the next year.

17 Jul 2008

New British consortium to tackle healthcare associated infections

Just over 8% of all hospital inpatients in England develop a healthcare associated infection, with this figure rising to 23% in intensive care units. Preventing and controlling the transmission of infection is a key priority for those involved in healthcare.

16 Jul 2008

Clostridium difficile closes hospital ward

An outbreak of Clostridium difficile (C. difficile) in a Scottish hospital is causing concern despite claims from health authorities that the outbreak is under control.

23 Jun 2008

Misoprostol off-label use may have led to deaths

Preliminary U-M studies indicate that oral use of RU-486's companion drug misoprostol is safe, but vaginal use may undermine body's immune responses

16 Jun 2008

Clostridium difficile killed on exposure to surfaces made of copper and its alloys, brass and bronze

Scientists in the Environmental Healthcare Unit at the University of Southampton in the U.K. have found that infectious bacterium Clostridium difficile is killed when exposed to surfaces made of copper and its alloys, brass and bronze. The results of the study have been published in the February 2008 issue of the Journal of Hospital Infection.

3 Jun 2008

New research into superbug Clostridium difficile

New research into the toxins, virulence, spread and prevention of the superbug Clostridium difficile is reported in the June special issue of the Journal of Medical Microbiology. These findings will play a crucial role in providing us with ammunition in the fight against a sometimes deadly pathogen.

1 Jun 2008

Lotion which glows under ultraviolet light lights up nasty bacteria

A team of Canadian scientists using a lotion which glows under ultraviolet light have shown that up to a third of patient toilets are not properly cleaned. Their findings, published in BioMed Central's journal, BMC Infectious Diseases, also show that spores from the nasty bacteria Clostridium difficile (C. difficile) linger in the loo even when it has been thoroughly wiped down.

11 May 2008

New deadly superbug Steno an ever-increasing threat

Scientists in the Britain say hospitals could be facing an increasing threat from yet another deadly bacterial infection with the potential to rapidly develop a resistance to drugs.

8 May 2008

Scientists determine drug target for the most potent botulinum neurotoxin

Botulinum neurotoxin - responsible for the deadly food poisoning disease botulism and for the beneficial effects of smoothing out facial wrinkles - can also be used as a dreaded biological weapon. When ingested or inhaled, less than a billionth of an ounce can cause muscle paralysis and eventual death. Although experimental vaccines administered prior to exposure can inhibit the destructive action of this neurotoxin - the most deadly protein known to humans - no effective pharmacological treatment exists.

29 Apr 2008

Botox scare as scientists say the toxin may spread in the body

Scientists are warning that the anti-wrinkle treatment Botox used by millions of women every year can spread from the face to the brain.

3 Apr 2008

MRSA in hospital intensive care -- what's growing where?

Researchers are finding out which bugs grow in intensive care units to develop a novel sampling regime that would indicate the threat of MRSA and other superbugs in the environment, scientists heard (Monday 31 March 2008) at the Society for General Microbiology's 162nd meeting being held this week at the Edinburgh International Conference Centre.

31 Mar 2008

A national Clostridium difficile prevalence study

The Association for Professionals in Infection Control and Epidemiology (APIC) has announced a detailed strategy to combat Clostridium difficile-associated disease (CDAD).

24 Mar 2008

Anadis licenses antibody technologies from ImmuCell

Anadis Limited, an Australian-based biotechnology company focused on milk derived polyclonal antibodies and other milk-derived bioactives, announced today that it had signed a final agreement with ImmuCell Corporation, a biotechnology company headquartered in Portland, Maine, USA.

11 Mar 2008