Cocaine dependence (or addiction) is physical and psychological dependency on the regular use of cocaine. It can result in severe physiological damage, psychosis, schizophrenia, lethargy, depression, or a potentially fatal overdose.
The environmental context in which addicts experience the rewarding effects of cocaine can readily elicit cocaine-associated memories. These memories persist long after abstinence and trigger cocaine-craving and consumption.
Approximately 1.5 million Americans use cocaine in a given year, according to the National Institute on Drug Abuse. Many are repeat users. Unfortunately, there are currently no FDA-approved medicinal treatments for cocaine addiction.
Researchers at The University of Texas at San Antonio have revealed significant insight into cocaine addiction, a phenomenon which has grown significantly in the United States since 2015.
A study in cocaine-addicted rats reports long-lasting increases in the number of neurons that produce orexin—a chemical messenger important for sleep and appetite—that may be at the root of the addiction.
Bile acids -- gut compounds that aid in the digestion of dietary fats -- reduce the desire for cocaine, according to a new study by researchers at Vanderbilt University Medical Center and the University of Alabama at Birmingham.
A class of proteins that has generated significant interest for its potential to treat diseases, has for the first time, been shown to be effective in reducing relapse, or drug-seeking behaviors, in a preclinical study.
Exercise can help prevent relapses into cocaine addiction, according to new research led by the University at Buffalo's Panayotis (Peter) Thanos, PhD.
Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina in an article published online in June 2018 by Addiction Biology.
Cocaine can have a devastating effect on people. It directly stimulates the brain's reward center, and, more importantly, induces long-term changes to the reward circuitry that are responsible for addictive behaviors.
A study in Biological Psychiatry has identified unique genetic changes in the brain's reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal.
Scientists at The University of Texas at Austin have successfully tested in animals a drug that, they say, may one day help block the withdrawal symptoms and cravings that incessantly coax people with alcoholism to drink.
Cocaine and other drugs of abuse hijack the natural reward circuits in the brain. In part, that's why it's so hard to quit using these substances.
Last year, more than 60,000 Americans died of an opioid overdose, and millions more struggled with opioid and cocaine addiction.
Drug addiction continues to plague vast numbers of people across the world, destroying and ending lives, while attempts to develop more effective pharmaceutical addiction treatments continue.
For years, scientists have known that mitochondria in brain cells play a role in brain disorders such as depression, bipolar disorder, anxiety and stress responses.
Research released today highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction.
Several studies have provided strong evidence that adolescents--people in their teens to early twenties--have a higher vulnerability than adults to addictive substances like cocaine.
Psychology is hot, and it's only getting hotter. It's critical to the development of such technological innovations as self-driving cars and smart devices.
Studying the effect of environmental stressors on the development of cocaine use is the focus of a $2.6 million award from the National Institutes of Health to researchers at McGovern Medical School at The University of Texas Health Science Center at Houston.
Sanford Burnham Prebys Medical Discovery Institute is pleased to announce the National Institute on Drug Abuse at the National Institutes of Health has awarded Nicholas Cosford, Ph.D., a three-year, $10.8 million grant to pursue the preclinical development of a new class of medicine to treat substance use disorders.