Colorectal News and Research

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Novel chemotherapy and biological agents brings dramatic increase in metastatic colon cancer survival

Novel chemotherapy and biological agents for metastatic colorectal cancer, combined with surgical advances in liver resection, have resulted in a dramatic increase in survival for patients with advanced disease, according to researchers at The University of Texas M. D. Anderson Cancer Center.

26 May 2009

Discovery of biological markers that may indicate poor breast cancer prognosis

A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation.

26 May 2009

Research suggests role of low vitamin D in cancer

In studying the preventive effects of vitamin D, researchers at the Moores Cancer Center at the University of California, San Diego, have proposed a new model of cancer development that hinges on a loss of cancer cells' ability to stick together. The model, dubbed DINOMIT, differs substantially from the current model of cancer development, which suggests genetic mutations as the earliest driving forces behind cancer.

22 May 2009

Discovery in colon cancer prevention

A new study finds that individuals who have low expression of the "Celebrex gene," 15-PGDH, are actually resistant to Celebrex treatment when used to prevent colon cancer.

18 May 2009

Healthy living helps older, overweight cancer survivors reduce functional decline

A home-based diet and exercise program reduced the rate of functional decline among older, overweight long-term survivors of colorectal, breast and prostate cancer, according to a study in the May 13 issue of JAMA, the Journal of the American Medical.

12 May 2009

New understanding of role ZBP1 gene plays in breast cancer

Scientists at Albert Einstein College of Medicine of Yeshiva University have discovered how a gene crucial in triggering the spread of breast cancer is turned on and off. The findings could help predict whether breast tumors will metastasize and also reveal potential drug targets for preventing metastasis.

12 May 2009

Urban dwellers at greater risk of late-stage cancer

People who live in urban areas are more likely to develop late-stage cancer than those who live in suburban and rural areas. That is the conclusion of a new study published in the June 15, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society.

12 May 2009

RNA production revs up during cell-to-cell contact

MicroRNAs are single-stranded snippets that, not long ago, were given short shrift as genetic junk. Now that studies have shown they regulate genes involved in normal functioning as well as diseases such as cancer, everyone wants to know: What regulates microRNAs?

3 May 2009

DNA protecting protein helps cancer drug to kill cells

Some DNA repair enzymes can become double-edged swords - If they work too slowly, they can block necessary cell maintenance and contribute to cell death.

30 Apr 2009

New findings on COX-2 inhibitor side effects

In searching for a simple way to identify individuals with smoking-related lung injury, scientists at Weill Cornell Medical College have stumbled upon a potential explanation for why the class of pain-relievers known as COX-2 inhibitors increases the risk of heart problems among users.

29 Apr 2009

Cancer incidence, mortality, treatment and survival in Ireland

Survival rates for cancer are continuing to rise even though the number of cases being diagnosed is increasing, an all-Ireland report reveals.

26 Apr 2009

Expert panel on prostate cancer screening and prevention

The American Urological Association (AUA) will offer journalists the opportunity to hear from world-renowned experts about prostate cancer screening and prevention during a special expert panel session on April 27, 2009 at 12:15 p.m.

26 Apr 2009

Teleradiology offers CT colonography to rural areas

CT colonography, which is a highly effective colorectal screening test, is feasible in rural health centers with the help of teleradiology, according to a study performed at the University of Arizona in Tucson, AZ.

23 Apr 2009

Discovery of common genetic variation associated with colorectal cancer

Genetics plays a key role in determining risk for colorectal cancer, the second leading cause of cancer-related deaths in the United States.

23 Apr 2009

Hormone therapy may lower colorectal cancer risk in women

In a large study, a national team of researchers led by Mayo Clinic scientists observed that self-reported use of hormone therapy was associated with a significantly lower colorectal cancer risk.

22 Apr 2009

AEterna Zentaris presents results for AEZS-112 in advanced cancer and lymphoma

AEterna Zentaris Inc. has presented a poster outlining Phase 1 results for its orally-active tubulin and topoisomerase II inhibitor compound, AEZS-112, in patients with advanced solid tumors or lymphoma, which may potentially provide a new therapeutic approach for the treatment of cancer.

22 Apr 2009

CXL12 protein may slow spreading of colorectal cancer

Medical College of Wisconsin Cancer Center researchers in Milwaukee have learned that a protein, CXCL12, that normally controls intestinal cell movement, has the potential to halt colorectal cancer spreading.

22 Apr 2009

Potential genetic cause of congenital defect colonic atresia

In a finding that helps resolve a long-standing question in developmental biology, Klaus H. Kaestner, PhD, Professor of Genetics, and colleagues report in the journal Developmental Cell this week about how the mammalian gut forms. Mice were genetically engineered to lack the protein Cdx2 in the cells that normally go on to form the stomach and intestine.

22 Apr 2009

Burnt meat may increase the risk of pancreatic cancer

Meat cooked at high temperatures to the point of burning and charring may increase the risk of pancreatic cancer, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

22 Apr 2009

Removal of ovaries during hysterectomy increases risk of death, outweighs benefits

Results of a landmark study led by a doctor at John Wayne Cancer Institute at Saint John's Health Center raises serious questions about the long-term survival benefits of removing a woman's ovaries during routine hysterectomy.

20 Apr 2009