Computational Modeling News and Research

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New computational model of human kinase may provide insights for cancer drug development

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers.

4 Apr 2019

New study offers insight into development of delusions

Delusions are one of the most common symptoms of psychosis, but little is known about what causes them. A new study from researchers at Columbia University and New York State Psychiatric Institute offers insight into the development of delusions, which could lead to better treatments for people with psychosis.

22 Mar 2019

Smoking during pregnancy increases SUID risk

The first findings to result from a collaboration between Seattle Children's Research Institute and Microsoft data scientists provides expecting mothers new information about how smoking before and during pregnancy contributes to the risk of an infant dying suddenly and unexpectedly before their first birthday.

11 Mar 2019

Custom-designed proteins may help generate antibodies to inhibit HIV infection

A new way to create proteins that can sneak through HIV's protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers.

27 Feb 2019

New simulations offer insights on vital atomic-scale drug-cardiac cells interactions

To unravel the mysterious mechanisms of drug potency for the treatment of cardiac arrhythmias, a group of researchers at UC Davis have developed novel simulations that provide insights on vital atomic-scale drug-cardiac cells interactions.

8 Feb 2019

Computational model of the heart’s mitral valve enables customized care for patients

Engineers at The University of Texas at Austin have developed a new noninvasive technique for simulating repairs to the heart's mitral valve with levels of accuracy reliable enough for use in a clinical setting.

30 Jan 2019

Older adults care about strangers' welfare in financial decision-making, study finds

A recent study by researchers from the National University of Singapore found that when it comes to making financial decisions under risk, older adults will regard the financial outcomes of others' as their own and make choices that they would have selected for themselves.

30 Dec 2018

Scientists uncover direct link between brain cell size and IQ level

Scientists working within the Human Brain Project have for the first time uncovered a direct relation between brain cell size and IQ level.

21 Dec 2018

GABA cells help fight alcohol dependence, study finds

Scientists of the Higher School of Economics, Indiana University, and École normale supérieure clarified how alcohol influences the dopamine and inhibitory cells in the midbrain that are involved in the reward system and the formation of dependency on addictive drugs.

19 Dec 2018

Ground-breaking computer models could boost treatment of common cardiac condition

Ground-breaking computer models that simulate the workings of individual patients' hearts could boost treatment of a common cardiac condition that affects a million people in the UK and countless more worldwide.

27 Nov 2018

Researchers to develop computer-based tools for use in cancer research

The doctoral program 'CompCancer - Computational Methods in Oncology: Towards Personalized Medicine in Cancer Therapies' has received approval from the German Research Foundation.

21 Nov 2018

Maverick immune cells can act independently to identify and kill cancer cells, finds research

Immune cells called Gamma Delta T cells can act independently to identify and kill cancer cells, defying the conventional view of the immune system, reveals new research from the Francis Crick Institute and King's College London.

12 Nov 2018

$11 million NIH grant for Clemson University helps launch new center for musculoskeletal research

With an $11 million grant from the National Institutes of Health Center for Biomedical Research Excellence, Clemson University has launched the South Carolina Center for Translational Research Improving Musculoskeletal Health, or SC-TRIMH, a new research center that will bring together scientists from across South Carolina to change the way musculoskeletal disorders are diagnosed, treated and even studied.

19 Oct 2018

Researchers study motor, cognitive effects of DBS in patients with Parkinson's disease

Researchers from Charité - Universitätsmedizin Berlin have studied motor and cognitive effects of deep brain stimulation in patients with Parkinson's disease.

28 Aug 2018

Case Western Reserve gets three-year grant to enhance food systems in Cleveland neighborhoods

A multidisciplinary research team led by Case Western Reserve University School of Medicine has received a three-year, $936,000 grant to use collaborative computational modeling approaches to promote better community health through more equitable food systems.

17 Aug 2018

Rethinking fundamental rule of stroke care: 'Time is brain!'

In 1993, neurologist Camilo R. Gomez, MD, coined a phrase that for a quarter century has been a fundamental rule of stroke care: "Time is brain!"

14 Aug 2018

NIH awards $6.5 million to establish multi-institution biomedical technology resource center

The National Institutes of Health have awarded $6.5 million to a consortium that includes the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai, the University of Washington, the University of Connecticut, and the University of Auckland, New Zealand, to establish the Center for Reproducible Biomedical Modeling.

13 Aug 2018

Mechanical engineer receives NIH grant to study various aspects of cell group behavior

Researchers have thought that cancer begins when a single cell goes rogue in the body, then begins to grow and multiply.

3 Aug 2018

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Certara, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, announced today that Clinical Pharmacology & Therapeutics has published its "Letter to the Editor" describing the important role that quantitative systems pharmacology can play in defining dosing criteria for first-in-human clinical trials, together with the European Medicines Agency's response.

26 Jul 2018

Study discovers hidden brain state dynamics that regulate performance and decision-making

Brain activity is driven by encounters with external stimuli and situations, simultaneously occurring with internal mental processes.

3 Jul 2018