Computational Modeling News and Research

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Researchers lay foundation for reliable blood clotting molecule models

Blood clots have long been implicated in heart attacks and strokes, together accounting for almost half of deaths annually in the United States.

19 Nov 2019

Research breakthrough may lead to new therapeutic targets for cancers

Computational modeling is the use of computers to simulate and study the behavior of complex systems. Computational approaches are widely adopted in the bioimedical sciences and can be used to sift through large volumes of complex data to extract recurrent patterns that may point to a disease's causes and effects.

15 Nov 2019

Study unravels how insulin interacts with its receptor

Since the discovery of insulin nearly 100 years ago, scientists have explored how it interacts with its receptor with the goal of improving the ability of therapeutic insulins to mimic the way insulin works in the body.

14 Nov 2019

New NIH grant could help develop novel tool to analyze unstructured data in safety reports

Reports that medical errors are the third leading cause of death in the United States have led the Institute of Medicine and several state legislatures to suggest that data from patient safety event reporting systems could help health care providers better understand safety hazards and, ultimately, improve patient care.

13 Nov 2019

Musical pleasure linked to right combination of uncertainty and surprise

Why is it that people find songs such as James Taylor's "Country Roads," UB40's "Red, Red Wine," or The Beatles' "Ob-La-Di, Ob-La-Da" so irresistibly enjoyable? In a study reported in the journal Current Biology on November 7, researchers analyze 80,000 chords in 745 classic U.S. Billboard pop songs--including those three--and find that musical pleasure comes from the right combination of uncertainty and surprise.

8 Nov 2019

New model based on dynamic neural code can help humans to localize sounds

One of the enduring puzzles of hearing loss is the decline in a person's ability to determine where a sound originates, a key survival faculty that allows animals - from lizards to humans - to pinpoint the location of danger, prey and group members.

6 Nov 2019

US Department of Defense provides support to develop AI tools for saving lives of badly injured soldiers

The US Department of Defense has awarded the Centre for Trauma Sciences at Queen Mary a $1.2 million (£976.500) grant to develop AI tools that could help save the lives of badly injured soldiers.

1 Oct 2019

UC Davis research team receives NIH grant to develop novel drugs for treating pain

A UC Davis research team, led by Vladimir Yarov-Yarovoy and Heike Wulff, will receive a $1.5 million grant from the National Institutes of Health to develop a novel class of peptides that are better at treating pain and don't have the side effects of opioids.

1 Oct 2019

International team receives $3.1 million NIH grant to find better ways to treat tetralogy of Fallot

An international team of researchers received a five-year, $3.1 million grant from the National Institutes of Health to discover new and better ways to treat a pediatric congenital heart condition known as tetralogy of Fallot, which affects a total of 85,000 individuals in the United States.

27 Aug 2019

New computational modeling technology to noninvasively assess likelihood of heart attack

The National Science Foundation has awarded $550,000 to fund a collaborative new research project to develop a noninvasive, computational modeling technology for assessing the likelihood of a heart attack in patients with high levels of plaque buildup in their arteries -- the primary cause of heart attack in the U.S. today.

22 Aug 2019

Predicting post-traumatic osteoarthritis using simplified computational models

Knee joint injuries, such as ligament rupture, are common in athletes. As the intact joint ligaments offer a precondition for joint stability, ligament injuries are often surgically reconstructed. However, in many cases these injuries or surgeries can lead to post-traumatic osteoarthritis.

20 Aug 2019

Scientists gain insights into how the brain perceives different odors

Scientists have looked deep into the brain to understand the relationships between the synapses of olfactory nerves and the functions of inhibitory interneurons.

31 Jul 2019

New EU-funded research project aims to fight breast cancer

The ability to control key forces that drive biological functioning would be a boon for a number of medical fields. With a focus on breast cancer, an EU-funded project is bringing together different research communities to work towards understanding and controlling cellular mechanics.

3 Jul 2019

Researchers determine atomic interactions that stabilize phase-changing proteins

Most of the well-studied proteins in our bodies are like metal; some can change shape easily, like aluminum foil, and others are rigid, like steel beams, but they typically have a solid, well-defined structure.

2 Jul 2019

New computational modeling method predicts how gut microbes change over time

A new computational modeling method uses snapshots of which types of microbes are found in a person’s gut to predict how the microbial community will change over time.

From PLOS ONE 28 Jun 2019

HBP scientists argue why brain simulations are indispensable for neuroscience

Simulations of large-scale networks of neurons are a key element in the European Human Brain Project. In a new perspective article scientists from the HBP argue why such simulations are indispensable for bridging the scales between the neuron and system levels in the brain.

6 Jun 2019

Biologists unravel new role for nervous system in regeneration

Biologists at Tufts University have developed a computational model of planarian (flatworm) regeneration that explains how fragments of planaria determine which end should form a tail and which should form a head.

25 Apr 2019

New computational model of human kinase may provide insights for cancer drug development

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers.

4 Apr 2019

New study offers insight into development of delusions

Delusions are one of the most common symptoms of psychosis, but little is known about what causes them. A new study from researchers at Columbia University and New York State Psychiatric Institute offers insight into the development of delusions, which could lead to better treatments for people with psychosis.

22 Mar 2019

Smoking during pregnancy increases SUID risk

The first findings to result from a collaboration between Seattle Children's Research Institute and Microsoft data scientists provides expecting mothers new information about how smoking before and during pregnancy contributes to the risk of an infant dying suddenly and unexpectedly before their first birthday.

11 Mar 2019