Congenital Birth Defect News and Research

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A congenital birth defect, also known as a congenital anomaly, is a condition that is present at birth due to structural deformities in the development of a fetus. Common examples of congenital birth defects include congenital heart disease, neural tube defects and Down syndrome.

Researchers find mechanisms behind the development of congenital birth defect

About one percent of the world population is born with a congenital heart defect, which affects about 40,000 U.S. births each year, but how these particular birth defects come about is largely unknown.

1 Aug 2022

Clinical study shows that clopidogrel not effective in infants with congenital heart diseases

One of the largest clinical trials done in infants with congenital (present at birth) heart diseases, published in the New England Journal of Medicine, shows that the increasingly common practice of using the drug clopidogrel (Plavix-) to reduce shunt-related blood flow issues is not effective in the dose studied.

21 Jun 2013

Ultrasound reliable alternative to X-rays for DDH screening in children

Developmental dislocation (dysplasia) of the hip (DDH) is a common congenital condition in which a child's upper thighbone is dislocated from the hip socket. The condition can be present at birth or develop during a child's first year of life. Plain radiography (X-rays) has long been the gold standard screening modality for this condition in 6-month-old children, despite concerns over exposing very young children to ionizing radiation.

10 Feb 2012

Researchers identify gene abnormality for most common congenital birth defect, clubfoot

Although clubfoot is one of the most common congenital birth defects, few genetic causes have been found. Now, researchers at Washington University School of Medicine in St. Louis have found what they believe to be the most common cause of inherited clubfoot yet discovered.

2 Jul 2010

Link found between cryptorchidism and genetic mutations

A small percentage of males born with cryptorchidism (failure of one or both testicles to descend into the scrotum), the most frequent congenital birth defect in male children, are more likely to have genetic mutations, including for a syndrome that is a common genetic cause of infertility, according to a study in the November 19 issue of JAMA .

18 Nov 2008

Custom-made bladders produced from patients' own cells

Scientists in the U.S. have produced custom-made bladders grown from patients' own cells which have been have been successfully transplanted and function well.

4 Apr 2006

First human recipients of laboratory-grown organs

The first human recipients of laboratory-grown organs were by Anthony Atala, M.D., director of the Institute for Regenerative Medicine at Wake Forest University School of Medicine. In The Lancet, Atala describes long-term success in children and teenagers who received bladders grown from their own cells.

4 Apr 2006

Psychological distress of parents of children with spina bifida

Parents of children with spina bifida suffer from more psychological distress than parents of able-bodied children. Research published in the open access journal BMC Pediatrics reveals that having a child with spina bifida (SB) has a negative effect on parents' psychological well-being.

25 Aug 2005