Corticosterone News and Research

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Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.

Alcohol exposure during early to mid-adolescence linked to chronic stress vulnerability

Drinking during early to mid-adolescence can lead to vulnerability to chronic stress, according to new research from Binghamton University, State University of New York.

25 May 2016

Scientists reveal link between depression and paraventricular thalamus

Scientists from the RIKEN Brain Science Institute have shown that a mouse strain with a mutation that leads to dysfunction of mitochondria--the "powerhouses" that provide energy to cells--spontaneously undergo periodic episodes of depression-like behavior that resemble those in human. Through this research, published in Molecular Psychiatry, the scientists uncovered a link between depression and the paraventricular thalamus, a region of the brain not previously tied to depression.

20 Oct 2015

Intestinal bacteria play crucial role in inducing anxiety, depression

Scientists from the Farncombe Family Digestive Health Research Institute at McMaster University have discovered that intestinal bacteria play an important role in inducing anxiety and depression.

29 Jul 2015

Reoccurring oxygen deprivation during pregnancy affects offspring's liver function

Sleep apnea, a disorder in which breathing repeatedly stops during sleep, is a potentially serious condition because it deprives the body of oxygen. It becomes an even more serious condition in pregnant women—who can be more prone to it—because the oxygen deprivation may affect the baby.

30 Mar 2015

Increased levels of stress hormones in mother can affect foetal development

Increased levels of stress hormones can lead pregnant mice to overeat, but affect growth of the foetus and, potentially, the long term health of her offspring, according to a study published today.

27 Jan 2015

Knocking down a single gene can help stop stress from causing infertility, miscarriage

Scientists from the University of California Berkeley have discovered that by knocking down a single gene, they can stop stress from causing female infertility and miscarriage - in rats.

14 Jan 2015

Female rats whose great grandparents exposed to toxins become more vulnerable to stress

Scientists have known that toxic effects of substances known as endocrine disrupting chemicals (EDCs), found in both natural and human-made materials, can pass from one generation to the next, but new research shows that females with ancestral exposure to EDC may show especially adverse reactions to stress.

26 Aug 2014

Even with no explicit memory of childhood trauma, PTSD can develop in adulthood

There are many forms of memory and only some of these may be critical for the development of posttraumatic stress disorder (PTSD), reports a new study by researchers at the University at Albany and the University of California Los Angeles.

14 Aug 2014

Blood expression levels of genes targeted by stress hormones could be biomarker for developing PTSD

Blood expression levels of genes targeted by the stress hormones called glucocorticoids could be a physical measure, or biomarker, of risk for developing Post-Traumatic Stress Disorder (PTSD), according to a study conducted in rats by researchers at the Icahn School of Medicine at Mount Sinai and published August 11 in Proceedings of the National Academy of Sciences (PNAS).

13 Aug 2014

Stress may accelerate cognitive decline later in life

A new study published in the June 18 issue of The Journal of Neuroscience adds to a body of evidence suggesting stress may accelerate cognitive decline later in life.

18 Jun 2014

Mannotriose regulates learning and memory signal transduction in hippocampus

The main component of the Chinese herb Rehmannia, mannotriose, can improve learning and memory. Dr. Lina Zhang and colleagues from Shanghai University of Traditional Chinese Medicine in China used 1 - 10 mol/L mannotriose to treat primary hippocampal neurons insulted with 1 - 10 mol/L corticosterone.

7 Jan 2014

Ghrelin hormone released during chronic stress may predispose people to PTSD

About a dozen years ago, scientists discovered that a hormone called ghrelin enhances appetite. Dubbed the "hunger hormone," ghrelin was quickly targeted by drug companies seeking treatments for obesity - none of which have yet panned out.

16 Oct 2013

Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment

Synthetic antidepressants present a narrow spectrum and side effects following long-term application. Recently, medical practitioners have shown interest in the use of Chinese medicines for the treatment of diseases and in the adjustment of the human response to stress.

7 Sep 2013

Stress exposure in early life increases anxiety and consumption of comfort foods in adulthood

Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, suggests that exposure to stress in the first few days of life increases stress responses, anxiety and the consumption of palatable "comfort" foods in adulthood.

30 Jul 2013

University researchers investigate the role of corticosterone in signaling fetal distress

A University of Calgary researcher has identified how a steroid hormone may indicate infant distress during labour and delivery. The study, published by PLOS ONE this month, suggests that a full-term, healthy baby preferentially secretes a different stress hormone than its mother does. That stress hormone, corticosterone, has not been previously studied in human development.

18 Jun 2013

Study: Infants secrete different stress hormone than their mothers during labor and delivery

During labor and delivery, infants preferentially secrete a different stress hormone than their mothers do, according to a new clinical study. The results will be presented Saturday at The Endocrine Society's 95th Annual Meeting in San Francisco and published in the open access journal, PLoS One.

18 Jun 2013

Study: Stress felt by dad leaves lasting impression on his sperm

Sperm doesn't appear to forget anything. Stress felt by dad-whether as a preadolescent or adult-leaves a lasting impression on his sperm that gives sons and daughters a blunted reaction to stress, a response linked to several mental disorders.

13 Jun 2013

New research reveals how acute stress primes brain for improved performance

Overworked and stressed out? Look on the bright side. Some stress is good for you. "You always think about stress as a really bad thing, but it's not," said Daniela Kaufer, associate professor of integrative biology at the University of California, Berkeley.

17 Apr 2013

Change of fatty diet can cause feelings like drug withdrawal and depression

Even before obesity occurs, eating fatty and sugary foods causes chemical changes in the brain, meaning that going on a diet might feel similar to going through drug withdrawal, according to a study published today by Dr. Stephanie Fulton of the University of Montreal's Faculty of Medicine and its affiliated CRCHUM Hospital Research Centre.

13 Dec 2012

Study elucidates memory-forming signal transmission in the hippocampus

The hippocampus represents an important brain structure for learning. Scientists at the Max Planck Institute of Psychiatry in Munich discovered how it filters electrical neuronal signals through an input and output control, thus regulating learning and memory processes.

27 Sep 2012