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New epigenetic clocks distinguish aging causes and effects

What causes us to age? New "clocks" developed by researchers may help point to the answers. Investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, unveil a new form of epigenetic clock – a machine learning model designed to predict biological age from DNA structure.

14 Feb 2024

Smoking, infection, and BMI found to significantly sway immune response, study shows

Study reveals how smoking, CMV latent infection, and BMI significantly influence cytokine release, impacting immune response variability and potentially affecting disease risk.

14 Feb 2024

Discovery on housekeeping genetic elements reveals a novel avenue in cancer therapy

Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code.

5 Jan 2024

Spicing up the fight: Saffron's powerful impact on prostate cancer revealed

Saffron-treated prostate cancer (PCa) cells.

3 Jan 2024

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

The study investigates the role of epigenetic changes in GLP1R gene polymorphisms on metabolically healthy obesity (MHO), revealing that apart from genetic variations, DNA methylation significantly influences the occurrence of MHO.

20 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

The association between neighborhood deprivation, DNA methylation, and gene expression in breast tissue for Black and White women with breast cancer

Researchers investigated the association between neighborhood deprivation and alterations in DNA methylation and gene expression in breast cancer tissues of Black and White women.

7 Nov 2023

New MECP2 gene variant identified and characterized in Rett syndrome

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, seizures, and cognitive disability.

30 Oct 2023

AI innovation "Sturgeon" transforms classification of central nervous system malignancies

Sturgeon, a patient-agnostic transfer-learned neural network, to enable molecular subclassification of CNS malignancies.

16 Oct 2023

Deep brain stimulation improves memory and promotes neuron growth in Rett mice

A recent study from the lab of Dr. Jianrong Tang, associate professor at Baylor College of Medicine and principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital shows that deep brain stimulation (DBS) of a specific brain region results in a significant and sustained improvement of memory in Rett mice.

13 Oct 2023

New blood test could detect ovarian cancer early, improve treatment

High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. It is also the most lethal form, in part because clinicians do not have effective ways to screen women for it during the cancer's early stages, when it's easiest to treat.

10 Oct 2023

Study helps explain how the brain adapts during a critical period of adulthood

Developing brains become shaped by the sights, sounds, and experiences of early life. The brain's circuits grow more stable as we age.

5 Oct 2023

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Number of patient participants needed for secondary approval of a new cancer drug.

29 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

Promising new cervical cancer test fills in the gap missed by Pap tests

Researchers assessed a novel human papillomavirus (HPV) and host deoxyribonucleic acid (DNA) methylation score for adenocarcinoma in-situ (AIS) and cervical adenocarcinoma (ADC) screening.

8 Sep 2023

Maternal obesity linked to childhood weight issues through DNA changes

Boston Birth Cohort study finds that maternal pre-pregnancy obesity alters newborn DNA methylation, potentially increasing the risk of obesity in the child. The research targets high-risk U.S. demographics and could guide future interventions for childhood obesity.

27 Aug 2023

CpG News and Research

New epigenetic clocks distinguish aging causes and effects

Smoking, infection, and BMI found to significantly sway immune response, study shows

Discovery on housekeeping genetic elements reveals a novel avenue in cancer therapy

Spicing up the fight: Saffron's powerful impact on prostate cancer revealed

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

Cannabis use alters DNA methylation, with implications beyond smoking effects

The association between neighborhood deprivation, DNA methylation, and gene expression in breast tissue for Black and White women with breast cancer

New MECP2 gene variant identified and characterized in Rett syndrome

AI innovation "Sturgeon" transforms classification of central nervous system malignancies

Deep brain stimulation improves memory and promotes neuron growth in Rett mice

New blood test could detect ovarian cancer early, improve treatment

Study helps explain how the brain adapts during a critical period of adulthood

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Promising new cervical cancer test fills in the gap missed by Pap tests

Maternal obesity linked to childhood weight issues through DNA changes

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Early lung cancer detection with a machine learning model based on imaging, clinical, and DNA methylation biomarkers

Epigenetic drug-sensitive biomarkers for cancer

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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