Craniofacial News and Research

RSS

Discovery of tendon cells that self-renew

Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by USC School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics - including the ability to proliferate and self-renew.

10 Sep 2007

Scientists speed healing of bone damage

Blocking a naturally occurring inhibitor of bone formation accelerates healing of skull defects in mice, say researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital. The finding advances the understanding of how the skeleton develops and opens new therapeutic avenues for many of the disorders that are expected to afflict aging baby boomers.

5 Sep 2007

Tonsil epithelial factors may influence oropharyngeal HIV transmission

Current research demonstrates that the tonsils may possess the necessary factors to act as a transmission site for the spread of HIV.

27 Jul 2007

Prenatal alcohol exposure alters brain activity in the frontal-striatal areas

Heavy prenatal alcohol exposure does not always lead to fetal alcohol syndrome (FAS); sometimes it can lead to cognitive and behavioral deficits in the absence of craniofacial features needed to make an FAS diagnosis.

25 Jul 2007

New pediatric sleep lab in upstate New York

The Pediatric Sleep Medicine Offices, the first pediatric sleep lab in upstate New York , has started doing overnight studies in its new location in Clinton Crossings.

19 Jun 2007

New insights into visual disturbances accompanying skull deformations

Most children with a craniofacial deformity known as unicoronal synostosis have the eye-alignment abnormality strabismus, reports a study in the May Journal of Craniofacial Surgery , published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

1 Jun 2007

New gene therapy can nearly eliminate arthritis pain

Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term damage to the affected joints, according to a study published today in the journal Arthritis and Rheumatism.

28 May 2007

Handheld instrument assesses dental disease in minutes

Who would have guessed that when the Star Trek medical diagnostic tool known as the tricorder makes its appearance in real life, the first user might be . . . your dentist.

5 Apr 2007

Expanded endonasal approach surgery removes tumors once deemed to be inoperable

A first-of-its-kind study published in the February issue of the Journal of Neurosurgery: Pediatrics suggests endoscopic brain surgery, pioneered by surgeons at the University of Pittsburgh Medical Center, has the potential to be safer and often more effective than conventional surgery in children with life-threatening conditions.

12 Feb 2007

New smart anti-microbial approach to preventing tooth decay

Preventing cavities could one day involve the dental equivalent of a military surgical strike. A team of researchers supported by the National Institute of Dental and Craniofacial Research report they have created a new smart anti-microbial treatment that can be chemically programmed in the laboratory to seek out and kill a specific cavity-causing species of bacteria, leaving the good bacteria untouched.

23 Oct 2006

Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers

In an attempt to increase the sensitivity of cancer biomarker detection and to decrease the need for large samples from which to detect those molecules, a multi-institutional research team has shown that a "forest" of single-walled carbon nanotubes can be used to detect lower levels of the prostate specific antigen (PSA) than is possible using the current commercial assay.

25 Sep 2006

SUMO1 gene implicated in cleft lip and palate defects

Researchers supported by the National Institutes of Health report in the current issue of the journal Science that a much-studied gene called SUMO1, when under expressed, can cause cleft lip and palate, one of the world's most common birth defects.

21 Sep 2006

NIH launches "Knockout Mouse Project"

The National Institutes of Health (NIH) today awarded a set of cooperative agreements, totaling up to $52 million over five years, to launch the Knockout Mouse Project.

7 Sep 2006

Mitochondrial DNA sequencing tool updated

High-tech laboratory tools, like computers, are often updated publicly as their analytical capabilities expand. In the September issue of the Journal of Molecular Diagnostics, NIH grantees report they have developed a second generation "lab on a silicon chip" called the MitoChip v2.0 that for the first time rapidly and reliably sequences all mitochondrial DNA.

30 Aug 2006

Scientists gain greater understanding of how embryos differentiate left from right

Researchers at the Forsyth Institute have discovered a new mechanism responsible for early left/right patterning, the process by which organs locate themselves on the left or right side of the body.

19 Apr 2006

Losartan can prevent progression of Marfan syndrome

A commonly prescribed blood pressure medication may provide the first ray of hope in preventing potentially deadly complications of Marfan syndrome, a genetic disease that weakens the structural meshwork of blood vessels.

11 Apr 2006

Saliva RNA test for oral cancer

Oral cancer is the 6th most common cancer in men and the 14th most common cancer in women. In the US, oral cancer will be diagnosed in an estimated 30,000 Americans this year and will cause more than 8,000 deaths.

9 Mar 2006

Gum destruction can start in diabetic children as young as six years old

A new study from Columbia University Medical Center has shown that the destruction of the gums can start in diabetic children as young as six years old. While the link between diabetes and periodontal disease was previously established, it was believed that the regression of gums began much later and increased with age.

21 Feb 2006

Gene discovery may prevent craniofacial birth defects

Craniofacial researchers have developed an animal model that explains how skull malformations occur and how they might be prevented.

22 Dec 2005

$Bone quality regulator identified - possible target for preventing and treating bone fractures$

Bone quality regulator identified - possible target for preventing and treating bone fractures

University of California - San Francisco (UCSF) scientists have determined that the quality of bone matrix, a key component of bone, is regulated by a molecule known as transforming growth factor beta.

13 Dec 2005