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Creatine is an endogenous amino acid which is synthesized from simpler amino acids, namely glycine, arginine and the sulfur-containing amino acid methionine. Approximately 95 percent of creatine in the body is stored in skeletal muscle.

Novartis LDE225 Phase II study for advanced basal cell carcinoma meets primary endpoint

Novartis announced today the results of a pivotal Phase II trial demonstrating that patients with locally advanced (laBCC) or metastatic basal cell carcinoma (mBCC) taking the investigational oral compound LDE225 (sonidegib) had marked and sustained tumor shrinkage after a median follow-up of 13.9 months.

2 Jun 2014

Levels of bisphenol A in men's urine could be marker of prostate cancer

Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men's urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

4 Mar 2014

Omega-3 supplements, sertraline could help prevent onset of depression and dementia in later life

A University of Sydney study is looking into the effectiveness of omega-3 supplements and the antidepressant, sertraline, in reducing depressive symptoms and cognitive decline in older people, in a bid to prevent the onset of depression and dementia in later life.

24 Feb 2014

MRI method to map creatine in heart may help detect disorders earlier than traditional methods

A new MRI method to map creatine at higher resolutions in the heart may help clinicians and scientists find abnormalities and disorders earlier than traditional diagnostic methods, researchers at the Perelman School of Medicine at the University of Pennsylvania suggest in a new study published online today in Nature Medicine.

13 Jan 2014

Diabetes blamed for brain neurochemical abnormalities in bipolar disorder

Diabetes may underlie some of the neurochemical abnormalities observed in the brains of patients with bipolar disorder, say researchers.

17 Dec 2013

Researchers identify potential biomarker to predict developmental problems in premature infants

Researchers have identified a potential biomarker for predicting whether a premature infant is at high risk for motor development problems, according to a study published online in the journal Radiology.

17 Dec 2013

Researchers identify new method to predict outcomes in heart failure patients

Researchers at the George Washington University School of Medicine and Health Sciences (SMHS) and Johns Hopkins University School of Medicine have identified a new method to determine whether a patient's heart will fail, which in the future may help physicians better treat patients and tailor therapeutic interventions.

16 Dec 2013

Researchers find decreased energy metabolism in heart cells as significant independent risk factor

Johns Hopkins researchers have identified a new way to predict which heart failure patients are likely to see their condition get worse and which ones have a better prognosis. Their study is one of the first to show that energy metabolism within the heart, measured using a noninvasive magnetic resonance imaging test, is a significant predictor of clinical outcomes, independent of a patient's symptoms or the strength of the heart's ability to pump blood, known as the ejection fraction.

11 Dec 2013

Novel approach confirms dysfunctional energy production in schizophrenia

A method of directly assessing creatine kinase in the brain provides “direct and compelling” evidence for abnormal bioenergetics in the brains of patients with schizophrenia, say the study authors.

12 Nov 2013

Schizophrenic hippocampal abnormalities blamed on glutamate

Elevated glutamate levels correlate with reduced tissue volume in the hippocampus of patients with schizophrenia, a study shows.

18 Oct 2013

Research: Vegetarian athletes can stay competitive with balanced plant-base diets

A balanced plant-based diet provides the same quality of fuel for athletes as a meat-based diet, provided vegetarians seek out other sources of certain nutrients that are more commonly found in animal products, according to a presentation at the 2013 Institute of Food Technologists Annual Meeting & Expo.

18 Jul 2013

Betaine boosts athletic performance by nearly 6%, study finds

According to a study supervised by Ithaca College's Exercise and Sport Sciences Chair Thomas Swensen, betaine—a nutrient found in shellfish and beets—boosts athletic performance by nearly six percent when added to a sports drink.

6 Jul 2013

Urine tests could improve diagnosis of liver cancer

New data from two clinical trials presented today at the International Liver Congress- 2013 demonstrate substantial improvements in the detection of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) using diagnostic urine tests.

26 Apr 2013

Scientists develop pig brain model to study human brain development

A mutual curiosity about patterns of growth and development in pig brains has brought two University of Illinois research groups together. Animal scientists Rod Johnson and Ryan Dilger have developed a model of the pig brain that they plan to use to answer important questions about human brain development.

16 Mar 2013

Tamoxifen can counteract some pathologic features in mouse model of DMD

A new study has found that tamoxifen, a well-known breast cancer drug, can counteract some pathologic features in a mouse model of Duchenne muscular dystrophy (DMD). At present, no treatment is known to produce long-term improvement of the symptoms in boys with DMD, a debilitating muscular disorder that is characterized by progressive muscle wasting, respiratory and cardiac impairments, paralysis, and premature death.

16 Jan 2013

Metabolomics clue to postoperative delirium

The choice of general anesthetic in children influences their cerebral metabolism, which in turn affects their risk for postoperative delirium, an imaging study shows.

21 Nov 2012

Researchers find that children's brains are more affected by inhaled anesthetic

Stony Brook University School of Medicine researchers have found that children's brains are more affected by an inhaled anesthetic than an intravenous anesthetic with increased levels of brain lactate.

29 Oct 2012

Creatine may fight major depression in women

Women battling stubborn major depression may have a surprising new ally in their fight—the muscle-building dietary supplement creatine.

7 Aug 2012

Glutamatergic system involvement in BD supported

Results from a systematic review and meta-analysis of published studies suggest that brain levels of glutamate plus glutamine are elevated in bipolar disorder patients compared with mentally healthy individuals.

2 Aug 2012

Array BioPharma announces positive results from ARRY-797 Phase 2 trial on osteoarthritis

Array BioPharma today announced that ARRY-797 met its primary endpoint in a randomized, placebo-controlled and active-controlled (oxycodone ER) Phase 2 clinical trial in 157 osteoarthritis patients suffering from moderate to severe knee pain despite the use of non-steroidal anti-inflammatory drugs (NSAIDs).

31 Jul 2012