Crohn's Disease News and Research

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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
Researchers unravel key molecular mechanism of autoimmune and inflammatory diseases

Researchers unravel key molecular mechanism of autoimmune and inflammatory diseases

Mount Sinai study uncovers potential link between Crohn's and Parkinson's in Jewish population

Mount Sinai study uncovers potential link between Crohn's and Parkinson's in Jewish population

New study shows how the immune system regulates gut fungal population

New study shows how the immune system regulates gut fungal population

Implanted robotic system stimulates tissue growth in stunted organs

Implanted robotic system stimulates tissue growth in stunted organs

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

Researchers design electronic nose to sniff out colon diseases

Researchers design electronic nose to sniff out colon diseases

International researchers find valuable clues for developing robust therapeutic agents against IBDs

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Specific diets may help prevent colorectal cancer in high-risk groups

Specific diets may help prevent colorectal cancer in high-risk groups

Study identifies potential markers for early diagnosis, treatment of oral tongue cancer

Study identifies potential markers for early diagnosis, treatment of oral tongue cancer

Dysfunctional gene may be cause of Crohn's disease in some patients

Dysfunctional gene may be cause of Crohn's disease in some patients

Researchers suggest role for MKL1 protein in development of inflammatory bowel disease

Researchers suggest role for MKL1 protein in development of inflammatory bowel disease

Scientists develop new, high resolution method for identifying microbial species and strains

Scientists develop new, high resolution method for identifying microbial species and strains

Study finds increasing incidence of inflammatory bowel disease in newly industrialized countries

Study finds increasing incidence of inflammatory bowel disease in newly industrialized countries

Researcher awarded $1.5 million to study role of tumor necrosis factor in IBD

Researcher awarded $1.5 million to study role of tumor necrosis factor in IBD

Penn researchers single out bacterial enzyme behind gut microbiome imbalance linked to Crohn’s disease

Penn researchers single out bacterial enzyme behind gut microbiome imbalance linked to Crohn’s disease

Inflammatory bowel disease patients over the age of 60 often receive older drugs

Inflammatory bowel disease patients over the age of 60 often receive older drugs

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Ozanimod effective against multiple sclerosis, enters New Drug Approval process with FDA

Breakthrough discovery could lead to better treatments for colon cancer, gut diseases

Breakthrough discovery could lead to better treatments for colon cancer, gut diseases

Study discovers new genetic risk loci linked to children's food allergies

Study discovers new genetic risk loci linked to children's food allergies

Researchers discover new regulatory role for protein that links diet and disease

Researchers discover new regulatory role for protein that links diet and disease