Crohn's Disease News and Research

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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
Home visits help new parents overcome tough histories, raise healthy children

Home visits help new parents overcome tough histories, raise healthy children

Drug-like molecule appears to interfere with inflammatory response in variety of diseases

Drug-like molecule appears to interfere with inflammatory response in variety of diseases

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Research identifies crucial insights into early T-cell development

Research identifies crucial insights into early T-cell development

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Sheffield scientists discover that simple arthritis drug could help treat blood cancer sufferers

Sheffield scientists discover that simple arthritis drug could help treat blood cancer sufferers

Mango intake exerts beneficial effects in progression and severity of IBD

Mango intake exerts beneficial effects in progression and severity of IBD

Researchers highlight role of micro-guests in pathologic processes

Researchers highlight role of micro-guests in pathologic processes

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

UA researchers seek to better understand NHE8 protein’s role in GI disorders, colon cancer

UA researchers seek to better understand NHE8 protein’s role in GI disorders, colon cancer

Living in rural households lowers person's risk of developing IBD, study finds

Living in rural households lowers person's risk of developing IBD, study finds

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Adherence to prescribed medication improves health and increases cost savings

Adherence to prescribed medication improves health and increases cost savings

Discovery could impact understanding, treatment of autoimmune and inflammatory diseases

Discovery could impact understanding, treatment of autoimmune and inflammatory diseases

Human colon organoids fill gap in effectively modeling common GI diseases

Human colon organoids fill gap in effectively modeling common GI diseases

Study shows how high fat diets can alter gut bacteria to combat harmful inflammation

Study shows how high fat diets can alter gut bacteria to combat harmful inflammation

Microscopic fungus exacerbates Crohn's disease symptoms, mice study shows

Microscopic fungus exacerbates Crohn's disease symptoms, mice study shows

AMSBIO introduce range of cancer exosome samples

AMSBIO introduce range of cancer exosome samples

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients