Crohn's Disease

Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

What is Crohn's Disease?

Crohn’s disease is essentially a disease that leads to severe inflammation of the lining of the digestive system.

Crohn's Disease Symptoms

Crohn's Disease Cause

Crohn's Disease Diagnosis

Crohn's Disease Treatment

Crohn's Disease Complications

History of Crohn's Disease

Intestinal Mycoplasma and Crohn's Disease

Latest Crohn's Disease News and Research

Innovative testing protocol reduces the lengthy wait for IBD diagnosis

Patients with suspected inflammatory bowel disease (IBD) could benefit from better testing protocols that would reduce the need and lengthy wait for potentially unnecessary colonoscopies, a new study has found.

16 Apr 2024

Study reveals microplastics' significant impact on digestive pathways

It's happening every day. From our water, our food and even the air we breathe, tiny plastic particles are finding their way into many parts of our body.

15 Apr 2024

Does IBD affect cancer risk?

Research suggests no strong genetic link between inflammatory bowel disease and increased cancer risk, with specific exceptions in European populations for Crohn's disease and ulcerative colitis.

3 Apr 2024

Systemic Inflammation Index: A new hope for autoimmune disease management

A routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of debilitating autoimmune diseases.

2 Apr 2024

New immunotherapy strategy potentially lays the groundwork for treating autoimmune diseases

Mayo Clinic scientists have developed an immunotherapy strategy that potentially lays the groundwork for treating a spectrum of autoimmune diseases.

1 Apr 2024

Vitamin D shows promise in targeting aging's biological mechanisms, study finds

What is currently known about the potential effect of vitamin D (VitD) on modulating some hallmarks of aging.

26 Mar 2024

Immune responses in mesenteric lymph nodes improve understanding of Crohn's disease

Crohn's disease is a chronic inflammatory bowel disease that is sometimes insufficiently controlled by immunosuppressive therapies with a subsequent need for surgical removal of affected bowel segments.

25 Mar 2024

Risk factors for serious inflammatory conditions in IBD patients identified

Investigators at Cedars-Sinai have identified risk factors that make inflammatory bowel disease (IBD) patients susceptible to developing serious conditions in other parts of their bodies.

20 Mar 2024

Implantable temperature sensor detects inflammatory flareups in patients with Crohn's disease

A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease.

18 Mar 2024

Scientists uncover an overlooked mechanism in the gut immune system of Crohn's disease patients

A team of scientists from DTU and other European universities have uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease.

13 Mar 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

New sprayable gel promises safer endoscopic surgeries

More than 20 million Americans undergo colonoscopy screenings every year, and in many of those cases, doctors end up removing polyps that are 2 cm or larger and require additional care.

12 Mar 2024

Study: Early advanced therapy significantly improves Crohn's disease outcomes

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

22 Feb 2024

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine's mechanism of action has been unclear.

20 Feb 2024

High-quality early diet linked to lower IBD risk in children

Early-life diet, particularly high-quality diets and fish intake at one year of age, is linked to a lower risk of developing inflammatory bowel disease (IBD) in children, underscoring the importance of dietary choices in infancy.

5 Feb 2024

High dietary intake of fish and vegetables in infancy may protect against IBD

Having a high dietary intake of fish and vegetables at 1 year of age, and a low intake of sugar beverages, seems to protect against inflammatory bowel disease

31 Jan 2024

High diet quality in early life associated with reduced risk of IBD

A high quality diet at the age of 1 may curb the subsequent risk of inflammatory bowel disease, suggests a large long term study, published online in the journal Gut.

31 Jan 2024

Immune protein Ku70 key in fighting bowel cancer

Study establishes Ku70's role in tumor suppression, showing that reduced expression or mutations in this DNA repair protein significantly increase intestinal cancer risk.

30 Jan 2024

Mount Sinai project receives $4M grant to understand the early stages of Crohn's disease

The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn's disease before noticeable symptoms develop.

25 Jan 2024

Mood boosters reduce inflammation in IBD by 18%, study finds

New King's College London research reveals that interventions which improve mood can reduce levels of inflammation in people with inflammatory bowel disease by 18 per cent, compared to having no mood intervention.

24 Jan 2024