Cross Linking News and Research

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Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Researchers have found that the y cross-chain structure of fibrin proteins is essential to stabilizing blood clots that can lead to harmful embolism formation.

29 Jun 2021

Nanobodies from nanomice and llamas show potent neutralizing activity against SARS-CoV-2 variants

While several COVID-19 vaccines have been approved to date, the constant evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) receptor-binding domain (RBD) has challenged the efficacy of these vaccines.

11 Jun 2021

Iksuda Therapeutics closes $47 million financing round

Iksuda Therapeutics (Iksuda) has announced it has completed a US $47 million (circa GB £34 million) financing round, co-led by Mirae Asset Capital and its subsidiaries, Celltrion and Premier Partners, with the Company being advised by Ashfords LLP. The funding will support the advancement of Iksuda’s lead ADC assets and expansion of its payload and conjugation platform technologies.

From Iksuda Therapeutics 8 Jun 2021

Bispecific antibodies neutralize SARS-CoV-2 and its variants

A new bioRxiv preprint study led by Joshua Tan from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, involves generating bispecific antibodies using a new method cross-linking the antibodies with adjacent spike proteins using dual N-terminal domain/receptor binding domain specificity.

7 Apr 2021

Researchers discover new molecular target that could treat idiopathic pulmonary fibrosis

Researchers at the University of Alabama at Birmingham have identified a new molecular target that could potentially treat the deadly, aging-related lung disease idiopathic pulmonary fibrosis (IPF).

10 Mar 2021

Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

At the virtual 17th US HUPO Conference (US HUPO 2021), Bruker Corporation (Nasdaq: BRKR) today announces progress with several collaborations in deep, unbiased plasma proteomics, leveraging the speed, sensitivity and dynamic range of 4D proteomics on timsTOF Pro systems.

From Bruker Life Sciences Mass Spectrometry 9 Mar 2021

Hydrogel dressings are better at promoting wound healing

The widespread use of high-speed and high-energy weapons in modern warfare has led to an increasing incidence of explosive injuries. For such wounds as well as those incurred in disasters and accidents, severe hemorrhage is the leading cause of death.

16 Feb 2021

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer.

27 Jan 2021

Researchers develop new technique to more efficiently isolate and identify rare T cells

Scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases.

12 Jan 2021

3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

Scientists have created an unprecedented 3-dimensional structural model of a key molecular "machine" known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and some other diseases.

14 Oct 2020

Rapid and sensitive detection of SARS-CoV-2 with functionalized magnetic nanoparticles

A recent study published on the preprint server arXiv in October 2020 shows the potential for using functionalized magnetic nanoparticles to detect the presence of the virus in a sample.

11 Oct 2020

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Now, a study by researchers from the University of California has shown that the N protein forms biomolecular condensates with the viral RNA in both in vitro and in vivo studies. The research titled, ‘SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA’, was published on the preprint server bioRxiv on September 14th, 2020.

15 Sep 2020

Cross Linking News and Research

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Nanobodies from nanomice and llamas show potent neutralizing activity against SARS-CoV-2 variants

Iksuda Therapeutics closes $47 million financing round

Bispecific antibodies neutralize SARS-CoV-2 and its variants

Researchers discover new molecular target that could treat idiopathic pulmonary fibrosis

Bruker announces new results in deep, unbiased plasma proteomics, PaSER 1.1 software and new cross-linking consumables at US HUPO 2021

Hydrogel dressings are better at promoting wound healing

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Researchers develop new technique to more efficiently isolate and identify rare T cells

3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

Rapid and sensitive detection of SARS-CoV-2 with functionalized magnetic nanoparticles

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Advances in Virus Epigenetics

Emerging hydrogel material could improve oral drug delivery

Researchers solve the mystery of genetic defect in horses

Scientists use microneedle patches to extract the skin’s interstitial fluid

Defining neurogenic niche proteome helps identify key regulators of neurogenesis

Study traces the molecular roots of hypertrophic cardiomyopathy

Researchers report first structural model for key enzyme associated with inherited eye diseases

Fluorescent carbon dots can effectively detect calcium levels in cells

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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