Cytokine News and Research

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Low-molecular weight human interleukin-1β antagonist discovered

Researchers described the detection of a human interleukin-1β antagonist with low molecular weight that disrupts interactions with the interleukin-1 receptor type I receptor.

11 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

New way to administer CAR-T-cell therapy could lead to fewer side effects

When Richard O'Neil, Ph.D., joined MUSC Hollings Cancer Center two years ago, he knew that he wanted to continue finding ways to make CAR-T-cell therapy easier on patients.

8 Sep 2023

Rethinking menopause: Experts call for individualized treatment and more research

A comprehensive review in the journal Cell provides an in-depth look at the biology, clinical outcomes, and treatment options for menopause, including the effects of hormonal changes on metabolic and cognitive functions. The article also discusses various therapeutic interventions, from hormone therapy to alternative medicines, and their efficacy in managing menopausal symptoms.

7 Sep 2023

Eating for health: how dietary interventions impact pre-diabetic oral and gut microbiome, metabolites and cytokines

Researchers evaluated the impact of two diets on the intestinal and oral microbiota, cytokines, and metabolites of 200 pre-diabetic individuals.

7 Sep 2023

Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC

Researchers reviewed the evidence for SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).

6 Sep 2023

Early viral exposure in mice weakens vaccine response, raising questions for human studies

Researchers at Washington University have demonstrated that early life exposure to multiple viruses in house mice dampens the immune response to SARS-CoV-2 vaccinations later in life. The study raises concerns about the applicability of common mouse models in immunological research, suggesting that prior pathogen exposure could be a significant variable in predicting vaccine efficacy.

5 Sep 2023

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

The study reveals that Novavax's updated XBB.1.5 vaccine effectively induces cross-neutralizing antibodies against multiple Omicron XBB sub-variants in both mice and non-human primates.

5 Sep 2023

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging."

31 Aug 2023

Unlocking tumor immune evasion: IL1RL1+ Treg cells and CAFs collaborate for immunotherapy resistance

Researchers demonstrated that the crosstalk between IL1RL1+ regulatory T-cells (Treg) and cancer-associated fibroblasts (CAFs) drives the tissue repairing.

30 Aug 2023

Non-alcoholic steatohepatitis progression blocked by ginger essential oil

Researchers explore the potential utility of ginger essential oil in preventing NASH.

29 Aug 2023

Inflammatory diets raise dementia and Alzheimer's risk

This research study links higher Dietary Inflammatory Index (DII) scores to an increased risk of developing dementia, specifically Alzheimer's disease. The findings suggest that anti-inflammatory diets may offer a preventive strategy for dementia, underlining the need for further research to validate these associations.

28 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

CPAP therapy can mitigate telomere shortening in sleep apnea patients

Obstructive sleep apnea (OSA) consists of multiple episodes of partial or complete closure of the upper airway that occur during sleep, leading to breathing cessation lasting more than ten seconds and sometimes even several minutes, followed by arousals and deep breathing.

23 Aug 2023

Study unveils how Cutibacterium acnes boosts epidermal lipids for enhanced barrier protection

The role of Cutibacterium acnes in improving the skin's barrier function.

23 Aug 2023

The standard of care and recent advancements in the control of skin inflammation

Researchers discuss current therapeutic interventions for atopic dermatitis in children and adolescents.

21 Aug 2023

Severe COVID-19 may cause long-term changes to innate immune system

Severe COVID-19 may cause long-lasting alterations to the innate immune system, the first line of defense against pathogens, according to a small study funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

18 Aug 2023

Proxalutamide shows promise as potential COVID-19 treatment

At the outset of the COVID pandemic, men appeared to suffer higher rates of severe illness and death, leading researchers to suspect a link between androgen receptors-;which bind to hormones like testosterone--and SARS-CoV-2 viral infection.

18 Aug 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

Cytokine News and Research

Low-molecular weight human interleukin-1β antagonist discovered

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

New way to administer CAR-T-cell therapy could lead to fewer side effects

Rethinking menopause: Experts call for individualized treatment and more research

Eating for health: how dietary interventions impact pre-diabetic oral and gut microbiome, metabolites and cytokines

Review identifies future research directions for the study of a SARS-CoV-2 reservoir in PASC

Early viral exposure in mice weakens vaccine response, raising questions for human studies

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

Unlocking tumor immune evasion: IL1RL1+ Treg cells and CAFs collaborate for immunotherapy resistance

Non-alcoholic steatohepatitis progression blocked by ginger essential oil

Inflammatory diets raise dementia and Alzheimer's risk

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

CPAP therapy can mitigate telomere shortening in sleep apnea patients

Study unveils how Cutibacterium acnes boosts epidermal lipids for enhanced barrier protection

The standard of care and recent advancements in the control of skin inflammation

Severe COVID-19 may cause long-term changes to innate immune system

Proxalutamide shows promise as potential COVID-19 treatment

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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