DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

DNA of people with depression, trauma is biologically older than healthy individuals

DNA from people who suffer from major depression is biologically older than that of healthy people by on average 8 months, suggesting that they are biologically older than their corresponding calendar age.

8 Oct 2018

Breastfeeding changes gene activity that regulates infant's response to stress

It has long been known that there are many physical and mental health benefits of breastfeeding for mothers and babies. But can these benefits be due to genetic changes induced by breastfeeding? New research suggests that connection.

27 Sep 2018

Henry Ford Health System receives $600k grant to study genetic makeup of gliomas

Henry Ford Health System's Department of Neurosurgery was awarded a $600,000 grant by the Department of Defense to study the genetic makeup of gliomas, a type of brain cancer, in hope of identifying new therapies.

19 Sep 2018

Researchers describe novel mechanism that links epigenetic change to translational control

Understanding how memories form and are retrieved has applications to psychiatric, neurological and neurodegenerative disorders, and may be helpful to attenuate maladaptive memories in psychiatric disorders.

7 Sep 2018

Sleep loss can confer increased risk of adverse weight gain, shows study

In a new study, researchers at Uppsala University now demonstrate that one night of sleep loss has a tissue-specific impact on the regulation of gene expression and metabolism in humans.

23 Aug 2018

Researchers describe underlying mechanisms of congestive heart failure

Congestive heart failure is a terminal disease that affects nearly 6 million Americans. Yet its management is limited to symptomatic treatments because the causal mechanisms of congestive heart failure -- including its most common form, ischemic cardiomyopathy -- are not known.

10 Aug 2018

Research highlights how heritable and environmental factors can influence epigenetic variations

New research highlights the extent to which epigenetic variation is influenced by both inherited and environmental factors.

3 Aug 2018

Multi-center study results demonstrate best-in-class performance of Bladder EpiCheck urine test

Nucleix Ltd., a leading cancer detection and screening company, announced today that the multi-center European study results with its Bladder EpiCheck urine test for the detection of bladder cancer recurrence, were published in the European Urology Oncology journal.

26 Jul 2018

Study finds link between DNA methylation and non-alcoholic fatty liver disease

DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But sometimes this process goes awry.

19 Jul 2018

Potential oocyte-specific factors that can drive somatic cell reprogramming

The promise of generating truly pluripotent stem cells from terminally differentiated adult cell types continues to captivate scientists who envision great potential for therapeutic interventions.

4 Jul 2018

Study: Administration of endocrine disruptor causes epigenetic changes in pregnant sow's DNA

The public debate on endocrine disrupting chemicals- exogenous substances that have the same or similar effects as endogenous hormones - has been going on for some time.

30 Jun 2018

Research shows why new cancer therapies fail to work on some patients

University of Otago research provides insights into an underlying mechanism that could explain why new cancer therapies to help treat metastatic melanoma do not always work on patients, paving the way for predicting which patients will benefit from certain drugs.

30 Jun 2018

DNA methylation predicts survival outcome in patients with glioma

A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene.

28 Jun 2018

Studying The Effects of Microgravity on Muscle Mass

Studying the effects of gravity on muscle cells can give us an insight into muscle wastage diseases, and potentially guide the development of new therapies. Professor Louis Yuge discusses his research and the cellular changes that occur in response to microgravity.

25 Jun 2018

DNA patterns in circulating blood cells can help identify spastic cerebral palsy

A Delaware team including Erin Crowgey, PhD, associate director of Bioinformatics with Nemours Biomedical Research, has published a study in the peer-reviewed journal BMC Bioinformatics, showing that DNA patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients.

22 Jun 2018

Researchers diagnose cerebral palsy using AI and next-generation sequencing

Researchers have shown that patients with spastic cerebral palsy (CP) can be identified using DNA methylation patterns in circulating blood cells.

22 Jun 2018

Scientists discover new mechanism controlling multiple sclerosis risk

While the DNA sequence remains the same throughout a person's life, the expression of the encoded genes may change with time and contribute to disease development in genetically predisposed individuals.

19 Jun 2018

Study: Effects of in vitro fertilization depend on genetic variation inherited from parents

In vitro fertilization affects the regulatory region of genes essential for placental and embryonic growth, as well as the birth weight.

19 Jun 2018

Researchers discover genomic characteristics that define testicular germ cell cancer

Testicular germ cell cancer, a disease that is rare but growing in incidence in men in the United States, is considered to be among the most curable of solid tumors. Now researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and a consortium of institutions have discovered the genetic and genomic characteristics that define the disease.

12 Jun 2018

Study reveals mechanism behind eye loss in blind cavefish

Blind cavefish lose critical eye tissues within a few days after their eyes begin to develop.

7 Jun 2018