DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Research provides new insights into epigenetic heterogeneity of Ewing sarcoma

Tumors of the elderly, such as breast cancer and colon cancer, accumulate thousands of DNA mutations.

31 Jan 2017

Lund researchers map entire methylome in insulin-producing pancreatic islets

Throughout our lives, our genes are affected by the way we live. Diet, exercise, age and diseases create imprints that are stored in something called methylome.

30 Jan 2017

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

Maternal infection during pregnancy increases the risk for psychiatric disorders in the child, but the path between the two is something of a mystery.

25 Jan 2017

New research provides insight into how estrogen modulates fear learning

Low estrogen levels may make women more susceptible to the development of post-traumatic stress disorder (PTSD) at some points in their menstrual cycles or lifetimes, while high estrogen levels may be protective.

19 Jan 2017

Study finds link between obesity-related disease and epigenetic modifications

Obesity has been linked to "letter" changes at many different sites in the genome, yet these differences do not fully explain the variation in people's body mass index (BMI) or why some overweight people develop health complications while others don't.

18 Jan 2017

Researchers identify new subgroup of cervical cancers with different genetic features

A team of University of South Carolina scientists led by Carolyn Banister and Phillip Buckhaults has identified a new subtype of cervical cancer that, like most cervical cancers, is triggered by human papillomavirus (HPV) but whose growth is not directed by the virus, suggesting that therapy targeting these tumors' distinct genomic pathways may improve patient outcomes over standard treatment.

11 Jan 2017

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver.

9 Jan 2017

Research sheds new light on key drivers of cancer metastasis

Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumours to other parts of the body. This phenomenon - known as metastasis - causes about 90 per cent of all cancer deaths.

21 Dec 2016

Viral infection during pregnancy affects maternal care and can trigger depression in offspring

A viral infection in a pregnant woman not only affects her subsequent ability to provide maternal care but can also trigger depression in her offspring, which can then even extend into the next generation as a result of changes to genetic mechanisms in the brain.

15 Dec 2016

Honeybee brain helps unravel mystery behind long-term memory formation

A breakdown of memory processes in humans can lead to conditions such as Alzheimer's and dementia.

8 Dec 2016

PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

Prostate-specific antigen (PSA) and other biomarkers are essential tools for diagnosing and monitoring prostate cancer.

8 Dec 2016

Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers of the Sarcoma research group of the Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, have first described the methylation profile of Ewing's sarcoma, a cancer of bone and soft tissues that mainly affects children and teenagers.

1 Dec 2016

Researchers identify simple, inexpensive tool for assessing prognosis of pediatric brain tumors

A multi-institutional group of researchers, led by investigators at Children's Hospital Los Angeles and the University of Michigan, have identified a simple and inexpensive tool for assessing the prognosis of pediatric brain tumors called ependymomas.

23 Nov 2016

Repeated binge drinking during adolescence can affect brain functions of future offspring

Repeated binge drinking during adolescence can affect brain functions in future generations, potentially putting offspring at risk for such conditions as depression, anxiety, and metabolic disorders, a Loyola University Chicago Stritch School of Medicine study has found.

15 Nov 2016

DNA Methylation News and Research

Further Reading

Research provides new insights into epigenetic heterogeneity of Ewing sarcoma

Lund researchers map entire methylome in insulin-producing pancreatic islets

Prenatal infection-induced epigenetic modifications may alter brain development in offspring

New research provides insight into how estrogen modulates fear learning

Study finds link between obesity-related disease and epigenetic modifications

Researchers identify new subgroup of cervical cancers with different genetic features

Epigenetic changes favor development of fatty liver in humans and mice

Research sheds new light on key drivers of cancer metastasis

Viral infection during pregnancy affects maternal care and can trigger depression in offspring

Honeybee brain helps unravel mystery behind long-term memory formation

PITX2 methylation biomarker shows promise for predicting prostate cancer recurrence risk

Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers identify simple, inexpensive tool for assessing prognosis of pediatric brain tumors

Repeated binge drinking during adolescence can affect brain functions of future offspring

Vitamin B12 deficiency during pregnancy may predispose children to type-2 diabetes

UCLA research shows epigenetic clock predicts lifespan

DNA damage caused by smoking may last a lifetime

UAB researchers find microRNA as potential therapeutic target for MDD

Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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