DNA Sequencing News and Research

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Genetic code for breast and colon cancers

Johns Hopkins Kimmel Cancer Center scientists have completed the first draft of the genetic code for breast and colon cancers.

7 Sep 2006

Mitochondrial DNA sequencing tool updated

High-tech laboratory tools, like computers, are often updated publicly as their analytical capabilities expand. In the September issue of the Journal of Molecular Diagnostics, NIH grantees report they have developed a second generation "lab on a silicon chip" called the MitoChip v2.0 that for the first time rapidly and reliably sequences all mitochondrial DNA.

30 Aug 2006

RNA gene found to be one of the fastest evolving regions in human genome

Since completing the sequencing of the chimpanzee genome last year, geneticists have spent many hours comparing human DNA sequences to those of our closest evolutionary relative, looking for the differences that distinguish the two species.

16 Aug 2006

New research may solve problem of vessels re-closing after angioplasty

Through studying pigeons with genetic heart disease, researchers at Wake Forest University School of Medicine have discovered a clue about why some patients' heart vessels are prone to close back up after angioplasty.

6 Aug 2006

New insights into how cells repair damaged DNA

Cancer researchers have discovered that a recently identified protein critical for repairing damaged genes uses an unusual mechanism to keep its repairs accurate.

26 Jul 2006

Cell survival depends on chromosome integrity

UCLA researchers report that thousands of genes behave differently in the same organs of males and females - something never detected to this degree.

9 Jul 2006

Genetically-engineered antivenom to improve the treatment of snake bite

Important breakthrough in using DNA sequencing rather than actual snake venom as the means to generate antivenom.

27 Jun 2006

New insight into the way an embryonic retina cell develops

The discovery provides a new vantage point for understanding how a healthy visual system develops. It also raises the possibility of re-directing the production of cell types as needed to stave off eye disease.

9 May 2006

Cancer found grow by switching off DNA - may lead to new generation treatments

Cancer researchers have formulated a new concept for how cancer cells can escape normal growth controls by turning off DNA. These findings may have far-reaching implications for the new generation of cancer therapies.

25 Apr 2006

Penn researchers discover gene that creates "second skeleton" bone disorder

Researchers at the University of Pennsylvania School of Medicine have located the "skeleton key," a gene that, when damaged, causes the body's skeletal muscles and soft connective tissue to undergo a metamorphosis into bone, progressively locking joints in place and rendering movement impossible.

23 Apr 2006

Researchers find gene connected to Lupus

Researchers at the University of Minnesota have identified a variant of a gene that is present in most people with lupus, a complex and chronic autoimmune disease.

20 Apr 2006

St. Jude develop strategy to speed future development of more effective and less toxic treatments for medulloblastoma

Investigators at St. Jude Children’s Research Hospital have developed a strategy to speed future development of more effective and less toxic treatments for medulloblastoma, a type of brain cancer. Medulloblastomas arise in the back of the brain and account for about 20 percent of childhood brain tumors.

18 Apr 2006

Common gene variation associated with an increased risk for obesity

A pioneering statistical technique developed at the Harvard School of Public Health (HSPH) has helped identify a common gene variation associated with an increased risk for obesity.

18 Apr 2006

Scientists reconstruct Darwinian evolution to explain 'irreducible complexity'

Using new techniques for resurrecting ancient genes, scientists have for the first time reconstructed the Darwinian evolution of an apparently "irreducibly complex" molecular system.

11 Apr 2006

Colorimetric screening detects DNA, small molecules and proteins

Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

11 Apr 2006