Delirium News and Research

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Delirium is a mental state in which a person is confused, disoriented, and not able to think or remember clearly. The person may also be agitated and have hallucinations, and extreme excitement.

Nurse-led initiatives reduce length of stay, improve patient outcomes in Philadelphia hospitals

Recent nurse-led initiatives addressing some of critical care's most pressing challenges resulted in shorter average lengths of stay and other positive patient and fiscal outcomes in seven Philadelphia-area hospitals.

16 Oct 2014

Study: Benzodiazepine sedatives may increase death risk in patients receiving mechanical ventilation

Sedation is frequently required for mechanically ventilated intensive care unit (ICU) patients to reduce anxiety, provide comfort, and assist in providing optimal respiratory support.

1 Oct 2014

Survey finds low awareness about risks of cognitive side effects following surgery

Postsurgical cognitive side effects can have major implications for the level of care, length of hospital stay, and the patient's perceived quality of care, especially in elderly and fragile patients. A nationwide survey of Swedish anesthesiologists and nurse anesthetists has found there is low awareness of the risks of cognitive side effects following surgery.

19 Aug 2014

Anti-cholinergic drugs could be responsible for decline in cognitive, physical function in elderly patients

Drugs widely prescribed to the elderly could be responsible for a decline in cognitive and physical function according to research from the University of East Anglia and the Regenstrief Institute.

31 Jul 2014

Stimulating specific brain pathway may induce active emergence from anesthesia

Researchers may be one step closer to better understanding how anesthesia works. A study in the August issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists- (ASA-), found stimulating a major dopamine-producing region in the brain, the ventral tegmental area (VTA), caused rats to wake from general anesthesia, suggesting that this region plays a key role in restoring consciousness after general anesthesia.

23 Jul 2014

DBS improves motor and non motor symptoms of patients with early Parkinson's disease

Deep brain stimulation (DBS) has become a well-recognized non-pharmacologic treatment that improves motor symptoms of patients with early and advanced Parkinson's disease.

26 Jun 2014

Two Regenstrief investigators receives Career Development K23 Awards from NIH

Two Regenstrief Institute investigators and Indiana University Center for Aging Research scientists -- Michael LaMantia, M.D., MPH, and Noll L. Campbell, PharmD -- have each received five-year Mentored Patient-Oriented Research Career Development K23 Awards from the National Institute on Aging at the National Institutes of Health.

13 Jun 2014

Critically ill patients receiving steroids in ICU are more likely to develop delirium

New Johns Hopkins research suggests that critically ill patients receiving steroids in a hospital’s intensive care unit (ICU) are significantly more likely to develop delirium. Results of their research, they say, suggest minimizing the use of steroids could reduce delirium in the ICU.

28 May 2014

New understanding of toxicity levels of chemotherapy regimens used for early stage breast cancer

Oncologists now have a new understanding of the toxicity levels of specific chemotherapy regimens used for women with early stage breast cancer, according to research from The University of Texas MD Anderson Cancer Center.

28 May 2014

Patients receiving steroids in hospital's ICU more likely to develop delirium, says study

New Johns Hopkins research suggests that critically ill patients receiving steroids in a hospital's intensive care unit (ICU) are significantly more likely to develop delirium. Results of their research, they say, suggest minimizing the use of steroids could reduce delirium in the ICU.

28 May 2014

Norwegian Accident and Emergency departments not designed for elderly patients

Norwegian Accident and Emergency departments are not designed for elderly patients, and their staff often lack geriatric experience.

20 May 2014

Patients with chronic pulmonary thromboembolic disease may benefit from PTE

Patients with chronic pulmonary thromboembolic disease may benefit from pulmonary thromboendarterectomy (PTE), even if the patients don't have severe pulmonary hypertension, according to University of California, San Diego, researchers.

19 May 2014

New intervention program may benefit chronically homeless, alcohol-dependent individuals

Chronically homeless, alcohol-dependent individuals might benefit from a new intervention that does not require them to stop or even reduce drinking, according to the results of a preliminary study in Seattle.

16 May 2014

Study: Depression affects more than one out of three critical care survivors

Depression affects more than one out of three survivors of critical illness, according to a Vanderbilt study released in The Lancet Respiratory Medicine, and the majority of patients experience their symptoms physically rather than mentally.

26 Apr 2014

Clot-busting tPA therapy for ischemic stroke patients can avoid lengthy, restrictive monitoring in ICU

A Johns Hopkins study of patients with ischemic stroke suggests that many of those who receive prompt hospital treatment with "clot-busting" tissue plasminogen activator (tPA) therapy can avoid lengthy, restrictive monitoring in an intensive care unit (ICU).

13 Feb 2014

Nearly half of hospitalized American adults age 65 require decision-making assistance

Nearly half of hospitalized American adults age 65 and older require decision-making assistance from family members or other surrogates because the patient is too impaired to make decisions independently, according to a new study from the Regenstrief Institute and the Indiana University Center for Aging Research.

23 Jan 2014

Basic hospice strategies can make last days of dying inpatients more comfortable and dignified

There is much value in training hospital and nursing home staff in the basics of palliative care to make the last days of a dying patient's life as comfortable and dignified as possible.

22 Jan 2014

Continued use of statins may help prevent delirium in critically ill patients

Continued use of statins may help prevent delirium in critically ill patients who received statins before hospital admission, according to a new study of 470 intensive care patients in the UK.

17 Jan 2014

Researchers identify first biomarker that appears to be associated with duration of delirium

Researchers from the Regenstrief Institute and the Indiana University Center for Aging Research have identified the first biomarker that appears to be linked to the duration of delirium.

16 Dec 2013

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

A series of advancements in genetically engineered cell therapies demonstrate early efficacy and safety in patients with blood disorders for whom standard treatments have been unsuccessful, according to data showcased today during the 55th American Society of Hematology (ASH) Annual Meeting and Exposition in New Orleans.

9 Dec 2013

Delirium News and Research

Further Reading

Nurse-led initiatives reduce length of stay, improve patient outcomes in Philadelphia hospitals

Study: Benzodiazepine sedatives may increase death risk in patients receiving mechanical ventilation

Survey finds low awareness about risks of cognitive side effects following surgery

Anti-cholinergic drugs could be responsible for decline in cognitive, physical function in elderly patients

Stimulating specific brain pathway may induce active emergence from anesthesia

DBS improves motor and non motor symptoms of patients with early Parkinson's disease

Two Regenstrief investigators receives Career Development K23 Awards from NIH

Critically ill patients receiving steroids in ICU are more likely to develop delirium

New understanding of toxicity levels of chemotherapy regimens used for early stage breast cancer

Patients receiving steroids in hospital's ICU more likely to develop delirium, says study

Norwegian Accident and Emergency departments not designed for elderly patients

Patients with chronic pulmonary thromboembolic disease may benefit from PTE

New intervention program may benefit chronically homeless, alcohol-dependent individuals

Study: Depression affects more than one out of three critical care survivors

Clot-busting tPA therapy for ischemic stroke patients can avoid lengthy, restrictive monitoring in ICU

Nearly half of hospitalized American adults age 65 require decision-making assistance

Basic hospice strategies can make last days of dying inpatients more comfortable and dignified

Continued use of statins may help prevent delirium in critically ill patients

Researchers identify first biomarker that appears to be associated with duration of delirium

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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