Disease Modeling News and Research

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New bioengineered lung model could help scientists to advance research in lung conditions

An interdisciplinary team of researchers from McMaster and SickKids are developing a cutting-edge lung model that can better respond to viruses and drug treatments, giving scientists a tool to advance research in lung conditions like COVID-19, cystic fibrosis and allergens for asthma and air pollution.

18 Aug 2021

Non-invasive imaging method can predict the efficiency of cardiomyocyte differentiation

Stem cell research holds great potential for regenerative therapies and treatments to combat cardiovascular disease, which is responsible for over 30% of all deaths worldwide.

28 Jul 2021

Researchers model infection-spreading scenarios to understand the impact of COVID-19

Researchers at the Niels Bohr Institute, University of Copenhagen, together with epidemiologist Lone Simonsen from Roskilde University form part of the panel advising the Danish government on how to tackle the different infection-spreading situations we have all seen unfold over the past year.

25 Jun 2021

Researchers explore new ways to culture living heart cells for microgravity research

As part of preparing for an experiment aboard the International Space Station, researchers explored new ways to culture living heart cells for microgravity research.

29 May 2021

Mechano-immunological response to SARS-CoV-2

In a recent study, researchers demonstrated a human organ-on-a-chip (Organ Chip) microfluidic model of the lung alveolus (Alveolus Chip) - that recapitulates the human alveolar-capillary interface with an air-liquid interface (ALI) and vascular fluid flow to understand the local triggers in the lung in vitro.

5 May 2021

SFU mathematics professor to lead new infectious disease modeling network

Simon Fraser University mathematics professor Caroline Colijn will lead a new, national infectious disease modeling network that will inform decisions related to public health threats and better prepare Canada for future pandemics.

9 Apr 2021

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2-;the virus that causes COVID-19 – and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects. In their experiments in fruit flies and human cell lines, the team discovered the cell process that the virus hijacks, illuminating new potential candidate drugs that could be tested for treating severe COVID-19 disease patients.

29 Mar 2021

Researchers identify new drug candidates for treating patients with severe COVID-19

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2--the virus that causes COVID-19 - and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects.

27 Mar 2021

Research could lead to a personalized approach for treating sickle cell disease

Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research.

24 Mar 2021

Report: Probabilistic forecasts of the impact of vaccines and variants on the U.S. COVID trajectory

In a report summary released today Thomas McAndrew, a computational scientist and assistant professor at Lehigh University's College of Health includes probabilistic forecasts of the impact of vaccines and variants on the U.S. COVID trajectory over the next few weeks.

3 Mar 2021

Corning to highlight newest products in 3D cell culture portfolio at SLAS2021

Corning Incorporated will highlight its latest technologies that support the advancement of 3D cell culture, automation, and drug discovery at this year's virtual Society for Laboratory Automation and Screening (SLAS) conference on Jan. 25 through 27.

22 Jan 2021

Can the onset and end of an epidemic be predicted? A SARS-CoV-2 modeling case study

A recent study by researchers in France shows how differences in infection history and viral spread patterns are important factors in predicting the time course of a localized epidemic of SARS-CoV-2.

22 Jan 2021

RNA sequencing data reveals three major molecular subtypes of Alzheimer's disease

Researchers at the Icahn School of Medicine at Mount Sinai have identified three major molecular subtypes of Alzheimer's disease (AD) using data from RNA sequencing.

7 Jan 2021

How effective have COVID-19 control measures been in the UK?

Researchers in the UK and Australia have shown that epidemiologic models accounting for people’s behavior outside of measures introduced to control the coronavirus disease-19 (COVID-19) pandemic improve estimates of how effective such interventions have been.

21 Dec 2020

How does the UK’s COVID-19 response compare to others in Europe?

Researchers modeled the health benefits and economic loss caused by coronavirus disease 2019 (COVID-19) in the UK and compared them to four other western European countries. Their results suggest the British Government’s response may outweigh the economic loss incurred.

17 Dec 2020

Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome

Meier-Gorlin syndrome, or MGS, is a rare genetic developmental disorder that causes dwarfism, small ears, a small brain, missing patella and other skeletal abnormalities. In severe cases, MGS results in miscarriages and stillbirths.

14 Dec 2020

Researchers develop analytical model to gauge SARS-CoV-2 transmission dynamics in schools

Research highlight the risk of virus spread in schools in the Netherlands. Since most schools across countries have resumed in-person or face-to-face classes, knowing the virus's risk and transmission dynamics in this context is crucial.

9 Dec 2020

Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

8 Dec 2020

Study describes the early evolution of oral poliovirus vaccine

While the world reels from the spread of SARS-CoV2, the new coronavirus behind COVID-19, a much older and previously feared scourge--poliovirus--is close to being completely eradicated.

19 Nov 2020

Global collaboration provides a COVID-19 disease map

A collaboration of researchers from 120 different institutes across 30 countries including France, Germany, Australia, Japan, USA, India, Turkey, Brazil, and Canada initiated an effort to develop a COVID-19 Disease Map - a collection of computational models and diagrams of molecular mechanisms implicated in COVID-19.

2 Nov 2020