Drug Metabolism News and Research

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Optibrium launches a metabolism prediction software platform tailored to DMPK scientists

Semeta™ offers high sensitivity and superior precision for the prediction of Phase I and II metabolic routes, sites, products and liabilities in early drug discove.ry

From Optibrium Ltd. 27 Feb 2024

Rucaparib and its major metabolite exhibit differential biological activity and synergy

Once they enter the body, drugs, apart from carrying out their therapeutic function, are biochemically transformed by the action of the metabolic machinery, a process that facilitates their expulsion.

9 Feb 2024

Paxlovid enhances treatment options for COVID-19 patients

The design, synthesis, and mechanism of action of Paxlovid.

6 Feb 2024

New imaging technique could transform diagnosis and treatment of steatotic liver disease

Steatotic liver disease (SLD), previously known as non-alcoholic fatty liver disease, which includes a range of conditions caused by fat build-up in the liver due to abnormal lipid metabolism, affects about 25% of the population worldwide, making it the most common liver disorder.

9 Jan 2024

Optibrium’s Quantum Mechanics and Machine Learning Methods Predict Routes of Drug Metabolism

Peer-reviewed study published in Xenobiotica describes an innovative new method that predicts the routes and products of Phase I and II metabolism with high sensitivity and greater precision than other approaches.

From Optibrium Ltd. 7 Dec 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Does your gut microbiome play a role in therapeutic outcomes?

The role of the gut microbiome and its metabolites in altering the therapeutic outcomes

12 Oct 2023

Exploring the link between drugs and microbiota: a growing imperative in precision medicine

The intricate interactions between gut microbiota and drugs.

11 Oct 2023

Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

Optibrium, a leading developer of software and AI solutions for drug discovery, today launched the latest version of its drug discovery platform, StarDrop.

From Optibrium Ltd. 2 Oct 2023

Gut feeling: How your microbiome could be shaping your mental health

Researchers in Biological Psychiatry delve into the complex relationship between the gut microbiome and mental health disorders like depression and bipolar disorder. The study explores how not just gut bacteria, but also lesser-known gut microorganisms such as viruses, fungi, and parasites, play a pivotal role in mood disorders.

5 Sep 2023

Experts call for changes to how drugs are tested and labeled for people with obesity

A new opinion piece published in Health Affairs Forefront raises questions around current approaches to assess drug safety and effectiveness in people with obesity.

5 Sep 2023

Experimental drug can reduce symptoms of inflammatory bowel disease in pre-clinical models

A new study of mice and lab-grown human colon "organoids" indicates that an experimental drug developed by Johns Hopkins Medicine researchers can substantially reduce symptoms of inflammatory bowel disease (IBD) in pre-clinical models.

10 Aug 2023

Novel anti-cancer drug found to sensitize tumor cells to ferroptosis

A team of researchers led by Dr. Marcus Conrad from Helmholtz Munich discovered a novel anti-cancer drug, called icFSP1, which sensitizes cancer cells to ferroptosis.

28 Jun 2023

Point-of-care test identifies patients who may benefit from hypnosis interventions for pain treatment

Hypnosis is an effective treatment for pain for many individuals but determining which patients will benefit most can be challenging. Hypnotizability testing requires special training and in-person evaluation rarely available in the clinical setting.

15 Mar 2023

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

CN Bio, a leading Organ-on-a-Chip (OOC) company that designs and manufactures single-and multi-organ microphysiological systems (MPS), today announced the commercial launch of the PhysioMimix™ Single-organ Higher Throughput (HT) System.

From CN-Bio 28 Feb 2023

Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies

Researchers reported on AGORA2, an expansion of their previously published resource, AGORA, of genomewide metabolic reconstructions of human intestinal microbes.

26 Jan 2023

New resource of digital microbes created with focus on drug metabolism

Researchers at University of Galway associated with APC Microbiome Ireland, a world-leading SFI Research Centre, have created a resource of over 7,000 digital microbes – enabling computer simulations of how drug treatments work and how patients may respond.

20 Jan 2023

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation.

3 Jan 2023

Scientists suggest vibrational spectroscopy and nuclear magnetic resonance to evaluate drug concentrations

Scientists at Baltic Federal University have suggested evaluating concentration and chemical composition of drugs by means of vibrational spectroscopy and nuclear magnetic resonance instead of conventional complex approaches.

20 Dec 2022

Advances in nasal delivery of antibiotics

In a recent study published in the Journal of Drug Delivery Science and Technology, researchers reviewed the advances and challenges in the intranasal delivery of antibiotics.

17 Oct 2022