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Jump in cancer-related clots

Blood clots are increasingly common in cancer patients, but University of Rochester Medical Center researchers have created a novel risk model that can predict, with 98 percent certainty, which patients will not get a blood clot.

3 Aug 2007

CDC to provide intravenous artesunate for treatment of severe malaria

The Centers for Disease Control and Prevention (CDC) has received permission from the Food and Drug Administration (FDA) to provide intravenous artesunate for emergency use in the United States for persons with severe malaria.

3 Aug 2007

Possible anthrax drug targets

In the American government's biodefense efforts, the potential for terrorists to cause a deadly anthrax outbreak remains a significant concern, six years after the letter attacks that shook the nation shortly after 9/11.

3 Aug 2007

New pregnancy labeling rules should be approved without delay

Marks the tenth anniversary of a public hearing that was hoped to spark substantial changes in the way drugs are labeled for use during pregnancy.

2 Aug 2007

Genta and Emisphere Technologies file investigational new drug exemption

Genta Inc. and Emisphere Technologies, Inc. have jointly announced the submission of an Investigational New Drug Exemption (IND) to the Endocrinologic and Metabolic Drugs Division of the U.S. Food and Drug Administration (FDA) for a new drug known as G4544.

2 Aug 2007

Statins don't offset healthy choices

Within the medical field, it is often assumed that patients view cholesterol-lowering medications (or statins) as a license to eat whatever they like -- they figure their medication has them covered, so a steak here and there won't hurt.

2 Aug 2007

ARIUS announces allowance of US patent for lead anti-cancer antibody

ARIUS Research Inc., has announced that the Company has received notice from the United States Patent and Trademark Office that a key patent for its lead anti-CD44 drug candidate will issue on August 7th, 2007, as US Patent Number 7,252,821.

2 Aug 2007

Schizophrenia improved by mental and physical exercise

Scientists at Melbourne's Howard Florey Institute have shown that mental and physical exercise can improve behavioural deficits in schizophrenia and repair damaged chemical transmitter pathways in the brain.

1 Aug 2007

Drugs designed to disable enzyme TOPK could have anti-cancer benefits

Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death.

1 Aug 2007

Report reveals pregnancies exposed to accutane despite iPledge

Despite a mandatory program designed to prevent pregnant women from being exposed to the anti-acne medication Accutane and similar medications containing isotretinoin (a known teratogen or birth defect-causing agent), 122 pregnancies were exposed during the first year of the program, known as iPledge, a report revealed.

1 Aug 2007

New way to predict how cells will respond to targeted drug therapies

Models based on this approach could help doctors make better treatment choices for individual patients, who often respond differently to the same drug, and could help drug developers identify the ideal compounds on which to focus their research.

1 Aug 2007

Nanoparticles may provide safe pain control on the battlefield

University of Michigan scientists have received a pilot grant of nearly $1.3 million from the Defense Advanced Research Projects Agency to test whether nanoparticles can solve a pressing problem in battle zones like Iraq: how to administer sustained, safe doses of the most effective painkillers to injured soldiers, long before they can reach expert medical help.

1 Aug 2007

Huntington's disease study shows animal models on target

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.

1 Aug 2007

First mouse model of schizophrenia

Johns Hopkins researchers have genetically engineered the first mouse that models both the anatomical and behavioral defects of schizophrenia, a complex and debilitating brain disorder that affects over 2 million Americans.

1 Aug 2007

Zebrafish provide clues to cure for Lou Gehrig's disease

A small tropical fish, the curiosity of a Geisinger research scientist and some college students have created the perfect storm of sorts in an attempt to find a cure for one of the world's most devastating neurological diseases.

1 Aug 2007

Shutting off a critical cancer gene causes cancers in mice to self-destruct

Killing cancerous tumors isn't easy, as anyone who has suffered through chemotherapy can attest.

1 Aug 2007

donepezil improves symptoms of severe Alzheimer's

A drug initially used to treat mild to moderate Alzheimer's disease improved the memory and global function of people with severe Alzheimer's disease and was safe and effective, according to a study published in the July 31, 2007, issue of Neurology, the medical journal of the American Academy of Neurology.

1 Aug 2007