Ductal Carcinoma News and Research

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Papillary lesions of the breast should be surgically excised to avoid missing a cancer

Certain breast lesions diagnosed as benign on core needle biopsy have cancer at surgical excision and thus should be removed, according to a study appearing in the March issue of Radiology.

28 Feb 2006

MRI can detect breast disease missed by mammography

Researchers have found that mammography coupled with magnetic resonance imaging (MRI) is extremely sensitive in the detection of ductal carcinoma in situ (DCIS). DCIS, or early stage breast carcinoma, is a pre-invasive malignancy and MRI may help identify this type of disease, which may not be visible on a mammogram.

16 Feb 2006

Breast ducts - A new site for cancer treatment!

Johns Hopkins Kimmel Cancer Center researchers are studying whether delivering chemotherapy drugs directly to breast "plumbing" might make treatment of early breast cancer easier on the patient and at least as good as surgery or radiation.

26 Jan 2006

Gene that regulates normal embryonic development is found at high levels in virtually all forms of breast cancer

A gene that appears to help regulate normal embryonic development is found at high levels in virtually all forms of breast cancer, according to a new study led by Laszlo Radvanyi, Ph.D., associate professor of breast and melanoma medical oncology at The University of Texas M. D. Anderson Cancer Center.

25 Jul 2005

New search method could aid in the discovery of biomarkers for breast cancer

Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.

13 Jul 2005

Density of breast tissue can directly influence tumour development

New research suggests that there is a direct relationship between the density of breast tissue, and the risk of developing tumours in dense areas of the breast.

8 Jun 2005

Public-health efforts to increase the use of breast-cancer screening appear to have altered the types of breast cancer being diagnosed

Since 1980, the incidence of ductal carcinoma in situ, or DCIS, one of the most common kinds of early stage breast cancer, has increased more than sevenfold. This sharp increase in DCIS – which is a tumor that contains cancer-like cells but is not considered "true" cancer because the cells have not invaded normal breast tissue – has been accompanied by a flattening in the incidence of true invasive breast cancer.

11 Apr 2005

Women with non–invasive breast cancer carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer

The inherited breast/ovarian cancer genes are BRCA1 and BRCA2, which are associated with an increased risk of breast and/or ovarian cancer. The results are part of a five–year study of a common form of early stage breast cancer called ductal carcinoma in situ (DCIS).

7 Mar 2005

Non-invasive and invasive breast cancers share the same genetic mutations

Women diagnosed with early stage, non–invasive breast cancer who carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer, may benefit from high risk treatment, Yale researchers report in the February 23 issue of Journal of the American Medical Association.

23 Feb 2005

Study shows women with invasive lobular carcinoma may not need chemotherapy before surgery

Women with a rare type of advanced breast cancer who do not benefit from primary (pre-surgical) chemotherapy still have been found to do better in the long run than patients with a more common advanced breast cancer who do respond to chemotherapy.

3 Jan 2005

New approach to genomic testing identifies women with low risk of breast cancer recurrence

An initial validation study presented by Exagen Diagnostics at the San Antonio Breast Cancer Symposium suggests it may soon be possible to distinguish good prognosis from poor prognosis in any newly diagnosed breast cancer patient based on DNA changes in the patient's tumor.

13 Dec 2004

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Using precise, radioactively labeled genetic probes, researchers at Jefferson Medical College have seen cancer gene activity from outside the body in laboratory mice. The probes, which work by attaching to genetic codes copied from an active cancer gene, may someday aid physicians and scientists in cancer detection and in determining the appropriate treatment for a cancer.

13 Dec 2004

Breast MRI moderately useful for detecting breast cancer

In women with breast lesions that are suspicious for cancer, based on clinical examination or mammography, performing a breast MRI has high sensitivity but only moderate specificity for detecting breast cancer, but does not necessarily eliminate the need for tissue sampling, according to a study in the December 8 issue of JAMA.

8 Dec 2004

MRI most effective for detecting breast cancer for women with breast cancer gene mutations

MRI is more accurate for detecting breast cancer than mammography, ultrasound or clinical breast examination alone, in women who carry the BRCA1 or BRCA2 gene mutation, according to a study in the September 15 issue of JAMA.

10 Sep 2004

What is Telomere crisis?

Telomere crisis is an important early event in the development of breast cancer, and its occurrence can be identified with precision, according to recent findings by a team of scientists at the Department of Energy's Lawrence Berkeley National Laboratory and the University of California at San Francisco.

11 Aug 2004

Advances in biomedical imaging could lead to more sensitive screening tests for cancer-fighting drugs

Advances in biomedical imaging are allowing UC Davis researchers to use mice more effectively to study cancers comparable to human disease. The system can distinguish different stages of cancer and could lead to more sensitive screening tests for cancer-fighting drugs.

9 Aug 2004

Chemotherapy aimed at both cancer cells and their genetically normal cellular 'microenvironment' might improve the success of breast cancer treatment

In the first comprehensive survey of gene activity in each cell type composing normal and malignant breast tissue, scientists at Dana-Farber Cancer Institute have identified genes in non-cancerous supporting cells that can spur the growth of breast cancer cells.

20 Jul 2004

Clinical trial of 5 day treatment for earliest form of breast cancer

Researchers at Virginia Commonwealth University’s Massey Cancer Center have begun a clinical trial testing the effectiveness of an established balloon catheter radiation delivery device on the earliest form of breast cancer, ductal carcinoma in situ.

27 May 2004

Largest study ever finds male breast cancer on the rise

The rate of male breast cancer is on the rise and the disease in men is usually detected when the tumors are bigger, have spread and may be more aggressive, compared to diagnosis of the disease in women, concludes the largest study ever conducted of male breast cancer.

24 May 2004

Improvements needed in breast cancer treatment

Treatment of ductal carcinoma in situ (DCIS), a group of abnormal cells confined to the breast ducts, varies widely in the United States. Treatment ranges from potential over-treatment with aggressive surgical therapy to possible under-treatment by not providing radiation.

22 Mar 2004