Efficacy News and Research

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Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Patients with HER2-positive breast cancer that has started to spread to other parts of the body survive for longer if they are treated with a new drug called pyrotinib, according to results from the longest follow-up of the PHOEBE randomized clinical trial in China.

8 Nov 2023

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019. Since then, extensive efforts have been made to develop and evaluate vaccines to combat the virus.

8 Nov 2023

New antifungal molecule shows promise in combatting fungal infections without toxicity

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug's power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

8 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

Researchers assessed the efficacy and compared the relative effectiveness of various pharmacological treatments for alcohol use disorder.

8 Nov 2023

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Concurrent sequencing of DNA and RNA to detect the predisposition to hereditary cancer.

8 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

The study in Nature Microbiology reviews the concept of immune imprinting and its influence on antibody responses to SARS-CoV-2, highlighting challenges for COVID-19 booster vaccination efficacy against emerging variants. Researchers suggest that understanding immune imprinting is crucial for developing vaccines that elicit broad and lasting immune protection.

7 Nov 2023

JAK inhibitors and tocilizumab elicit better response rates in VEXAS syndrome

New research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, found that JAK inhibitors (JAKi) and tocilizumab elicited better response rates in VEXAS syndrome compared to other targeted therapies.

7 Nov 2023

Research brings the prospect of injection-free treatment closer for people with diabetes

A University of Alberta team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer for people with diabetes.

7 Nov 2023

Review: Antibiotic prescribing and stewardship in outpatient telemedicine

A new report in the peer-reviewed journal Telemedicine and e-Health provides a review of the published literature on antibiotic prescribing and antibiotic stewardship in outpatient telemedicine.

7 Nov 2023

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract.

7 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

New pathologic scoring system could help predict survival in lung cancer patients

A new pathologic scoring system that accurately assesses how much lung tumor is left after a patient receives presurgical cancer treatments can be used to predict survival, according to new research led by investigators at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center and the Mark Foundation Center for Advanced Genomics and Imaging at the Johns Hopkins University.

6 Nov 2023

New analysis of Indonesia Wolbachia trial shows potential for greater dengue reduction

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Efficacy News and Research

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

New antifungal molecule shows promise in combatting fungal infections without toxicity

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Pharmacogenomics holds promise for personalized dementia therapies

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

JAK inhibitors and tocilizumab elicit better response rates in VEXAS syndrome

Research brings the prospect of injection-free treatment closer for people with diabetes

Review: Antibiotic prescribing and stewardship in outpatient telemedicine

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

New pathologic scoring system could help predict survival in lung cancer patients

New analysis of Indonesia Wolbachia trial shows potential for greater dengue reduction

UTHSC's drug candidate for advanced prostate cancer goes to first clinical trial

Unraveling the role of HER2 mutant alleles in breast cancer

Overcoming T-cell exhaustion: A new hope for CAR-T cell therapy

Patients with chronic fatigue syndrome benefit from cognitive behavior therapy

SSRIs show promise in easing post-COVID struggles, Dutch study reveals

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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