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Small protein has a large impact on bacterial gene regulation

Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding protein ProQ is involved in the activation of more than 250 bacterial genes.

4 Jun 2020

Blood group type may affect susceptibility to COVID-19 respiratory failure

A group of over 120 researchers from various institutions across Europe has performed the first genome-wide association study to reveal host genetic factors that may contribute to respiratory failure in cases of coronavirus disease 209 (COVID-19).

3 Jun 2020

COVID-19 patients exhale millions of viral particles per hour

An international team of researchers reports that patients with coronavirus disease 2019 (COVID-19) release thousands of viral particles directly into the air simply though breathing.

3 Jun 2020

Artificial intelligence may help study the structures and properties of unknown samples

Researchers at the Institute of Industrial Science, The University of Tokyo (UTokyo-IIS) used artificial intelligence to rapidly infer the excited state of electrons in materials.

3 Jun 2020

Study shows Sofosbuvir alleviates COVID-19-related neurological symptoms

A group of researchers has studied the effects of an antiviral drug Sofosbuvir on human brain organoids infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Jun 2020

SARS-CoV-2 can adversely affect cardiac cells and heart function

A research group from Germany demonstrated a direct toxic effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on cardiac cells in their paper published on the bioRxiv* preprint server. The finding warrants an in-depth analysis of cardiac tissue in certain coronavirus disease (COVID-19) patients, as well as close monitoring for any direct cardiomyocyte injury.

2 Jun 2020

Bacteria lurking in cancer cells may affect treatment

Cancer cells are comfy havens for bacteria. That conclusion arises from a rigorous study of over 1,000 tumor samples of different human cancers.

2 Jun 2020

Cats resistant to SARS-CoV-2 reinfection

Researchers at Colorado State University have made important discoveries about domestic cats infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could address concerns about human-to-animal transmission and the role domestic pets might play in spreading the virus.

2 Jun 2020

A cytokine pattern that predicts adverse outcomes in COVID-19

A new study published on the preprint server medRxiv in May 2020 reports the discovery of a predictive pattern of cytokines in COVID-19 infection that could guide clinical management if validated.

2 Jun 2020

Specific immune suppression leads to severe COVID-19 disease

A new study published online on the preprint server medRxiv in May 2020 reports that specific changes in the way the human immune system responds to COVID-19 determine whether the individual develops moderate or severe illness.

2 Jun 2020

SARS-CoV-2 started spreading in the United States in January, CDC says

The United States has reported the highest number of infections across the globe, with more than 1.81 million confirmed cases and at least 105,000 deaths. The magnitude of the novel coronavirus spread hints that the virus may have started earlier than previously thought.

2 Jun 2020

Study reveals how essential SARS-CoV-2 protein can be stabilized and scaled for production

A research group from the University of Texas in Austin described a high-yield production of a stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S-protein) that may accelerate the development of vaccines and diagnostic tests. This methodological 'tour de force' paper is currently available on the bioRxiv* preprint server.

1 Jun 2020

Computer modeling reveals necessary vaccine efficacy threshold to prevent SARS-CoV-2 spread

A recent US study showed that in order to prevent or largely extinguish the coronavirus disease 2019 (COVID-19) outbreak without social distancing or any other measures, any vaccine would have to have an efficacy of at least 70%. The research paper is currently available on the medRxiv* preprint server.

1 Jun 2020

Findings indicate potential therapeutic interventions for Alzheimer’s and other diseases

A team of scientists from Japan recently achieved more efficient degradation of the human serum albumin protein-;an important protein in the blood-;via high-intensity infrared irradiation, by attaching a zinc metal complex to the protein.

1 Jun 2020

No specific COVID-19-linked lesions found despite extensive organ injury

A recent paper published online on the preprint server medRxiv in May 2020 reports autopsy results on COVID-19 patients. The paper concludes that there were no specific hallmark lesions of COVID-19 in any of the many organs found to be injured by the infection in patients who died of the disease.

1 Jun 2020

Significant number of COVID-19 positive cases asymptomatic, raising transmission concerns

There have been many instances of people testing positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who have no symptoms of the infection whatsoever. These asymptomatic patients are, however, still capable of spreading the infection without being aware of it, say experts.

31 May 2020

Ruxolitinib shows promise in severe COVID-19

An anti-inflammatory drug Ruxolitinib has shown promising results in the treatment of severe coronavirus disease COVID-19. The study titled, “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial,” was published as a pre-proof for the Journal of Allergy and Clinical Immunology.

31 May 2020

Rare deadly disease linked to coronavirus infection seen in children

Now, new evidence has shown that children with coronavirus disease (COVID-19) experience a Kawasaki-like illness, called multisystem inflammatory syndrome in children (MIS-C). The complication is akin to toxic shock syndrome, a condition that occurs due to sepsis. Though rare, the condition is life-threatening.

29 May 2020

Genomic variation and descent of SARS-CoV-2 strains in India

The pandemic of COVID-19 that is still affecting over 188 countries and territories the world over has taken over 359,000 lives in just under five months, while affecting at least 5.8 million people. Different strains have diverged from the original strain detected in Wuhan, China.

28 May 2020

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

A new study published on the online preprint server bioRxiv in May 2020 reports the construction and testing of a new ferritin-based antigen-bearing protein that has biological activity towards the ACE2 receptor. This could indicate its potential for development as a vaccine or antiviral.

28 May 2020