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Researchers uncover how small heat shock protein interacts with other proteins

In Alzheimer's disease proteins clump together to long fibrils causing the death of nerve cells. Small heat shock proteins can counteract this effect. Scientists, therefore, hope to deploy them as agents in the treatment of neurodegenerative diseases. Using the example of a small heat shock protein, researchers at the Technical University of Munich and the Helmholtz Zentrum Muenchen have now uncovered how the protein interacts with other proteins.

15 Oct 2015

Small heat shock protein as model for Alzheimer’s medication

In Alzheimer’s disease proteins clump together to long fibrils causing the death of nerve cells. Small heat shock proteins can counteract this effect. Scientists, therefore, hope to deploy them as agents in the treatment of neurodegenerative diseases. Using the example of a small heat shock protein, researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München have now uncovered how the protein interacts with other proteins.

13 Oct 2015

Scientists develop new molecular toolkit to investigate protein assemblies in human disease

A photograph may reveal how something looks, but direct observation can divulge how the objects behave. The difference can mean life or death, especially when it comes to fighting human disease.

29 Sep 2015

UC San Diego, TSRI form new consortium to map cells in space and time

Drawing on complementary strengths of two San Diego institutions, The Scripps Research Institute (TSRI) and the University of California, San Diego (UC San Diego) have formed a new consortium with a big mission: to map cells in space and time.

18 Sep 2015

Caltech researchers find antibody that can detect, neutralize HIV viruses in infected patients

Proteins called broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS. bNAbs have been found in blood samples from some HIV patients whose immune systems can naturally control the infection.

14 Sep 2015

Rice lab invents technique to characterize nanoscale spaces in porous materials

Rice University scientists led a project to "see" and measure the space in porous materials, even if that space is too small or fragile for traditional microscopes.

10 Sep 2015

Worldwide Protein Data Bank symposium focuses on multi-scale structural biology

The symposium titled with "Integrative Structural Biology with Hybrid Methods" is held focusing on the multi-scale structural biology, which aims to analyze structures of protein molecules and their assemblies, cellular machines, organelle, and even living cells and organisms by the hybrid methods, integrating many different technologies, such as chemical cross-links, MS spectrometry, FRET, Super-resolution microscopy, X-ray diffraction, NMR, and Computer modeling, in addition to Cryo-electron microscopy that has been attracting much attention these days.

10 Sep 2015

Brainbow technique reveals surprising data about brain's visual circuitry

Neuroscientists know that some connections in the brain are pruned through neural development. Function gives rise to structure, according to the textbooks. But scientists at the Virginia Tech Carilion Research Institute have discovered that the textbooks might be wrong.

28 Aug 2015

Cosmetic and cleaning products contain millions of plastic particles

Everyday cosmetic and cleaning products contain huge quantities of plastic particles, which are released to the environment and could be harmful to marine life, according to a new study.

27 Aug 2015

Long lasting flu vaccine using antibodies advance from TSRI and Janssen

Scientists from The Scripps Research Institute (TSRI) and the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen) have found a way to induce antibodies to fight a wide range of influenza subtypes—work that could one day eliminate the need for repeated seasonal flu shots.

26 Aug 2015

TSRI, Janssen collaborate to find universal flu vaccine

Scientists from The Scripps Research Institute and the Janssen Pharmaceutical Companies of Johnson & Johnson have found a way to induce antibodies to fight a wide range of influenza subtypes—work that could one day eliminate the need for repeated seasonal flu shots.

24 Aug 2015

Tiny nanocrystals could be used in advanced medical imaging technologies to light up cancer cells

Researchers in China have developed tiny nanocrystals that could be used in the next generation of medical imaging technologies to light up cancer cells.

20 Aug 2015

High pressure freezer with integrated light stimulation launched by Leica Microsystems

Leica Microsystems launches the Leica EM ICE, a new generation High-Pressure Freezer with fully integrated light stimulation option at the precision of a millisecond.

From Leica Microsystems GmbH 18 Aug 2015

Determining the dynein-dynactin complex structure: an interview with Dr Gabriel C. Lander

This is a macromolecular assembly is made up of two components, dynein and dynactin, that works to move molecular cargo (organelles, RNA, vesicles, proteins, viruses) along microtubule highways within our cells.

16 Aug 2015

EPFL scientists reveal that the brain is not as compact as we thought

Using an innovative method, EPFL scientists show that the brain is not as compact as we have thought all along. To study the fine structure of the brain, including its connections between neurons, the synapses, scientists must use electron microscopes. However, the tissue must first be fixed to prepare it for this high magnification imaging method.

11 Aug 2015

Pitt researchers figure out how to quantify beating action of cilia

Researchers at the University of Pittsburgh School of Medicine have figured out how to objectively quantify the beating action of cilia, the tiny, hair-like projections on cells that line nasal passages, the lungs and almost every other body tissue, according to a study published online today in Science Translational Medicine.

6 Aug 2015

New method helps determine titanium nanoparticles in sunscreen products

Loads of cosmetics like sunscreen lotions contain titanium dioxide. These nanoparticles are contentious. Experts suspect they may have harmful effects on people and the environment.

3 Aug 2015

TSRI awarded two grants to support development of effective vaccine against HIV/AIDS

The Scripps Research Institute has been awarded two grants from the Bill & Melinda Gates Foundation totaling more than $4.5 million to fund efforts to develop a vaccine against HIV/AIDS.

24 Jul 2015

Correlated Light & Electron Microscopy at the Universities of Delft and Groningen

DELMIC develops and manufactures products which are focused on high performance, user friendly, integrated microscopy solutions. Users of Delmic's SECOM solution for Correlated Light & Electron Microscopy (CLEM) have recently published a review in Nature Methods that illustrates the power of CLEM in the world of biology.

From Delmic B.V. 14 Jul 2015

New upright microscopes with LED and 19 mm FOV

Leica Microsystems launches the upright microscopes Leica DM4 B and Leica DM6 B for life science research and clinical applications.

From Leica Microsystems GmbH 7 Jul 2015