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Spike-based DNA vaccine shows excellent protection against SARS-CoV-2 in a hamster model

A study conducted at the United States Army Research Institute of Infectious Diseases shows how a relatively simple full-length DNA vaccine against spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can elicit neutralizing antibody response in an animal model – even after a single shot with simple jet injection technique.

11 Nov 2020

Researchers identify new strategy to combat loss of skeletal muscle mass

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that stimulating expression of a protein naturally produced by the human body can be a strategy to combat loss of skeletal muscle mass, which happens normally with aging but can intensify in cases of neurodegenerative or inflammatory disease, or in patients who spend long periods in intensive care units (ICUs).

9 Nov 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

New medical instruments with smart sensors can improve surgery, therapy for cardiac diseases

Researchers developed a new class of medical instruments equipped with an advanced soft electronics system that could dramatically improve the diagnoses and treatments of a number of cardiac diseases and conditions.

7 Sep 2020

Interleukin-12 electroporation led to clinical responses in patients with advanced melanoma

Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in patients with immunologically quiescent advanced melanoma, according to results from a phase II trial.

6 May 2020

Using 'own' immune cells to fight infectious diseases including COVID-19

A provocative paper from Duke-NUS Medical School, published in the Journal of Experimental Medicine in March 2020, discusses the possibilities of creating new receptors on a sick person's own immune cells as a means of controlling the infection. This therapy is already being used to treat certain cancers with marked success.

22 Apr 2020

Researchers are exploring potential therapy for controlling infectious diseases

The engineering of specific virus-targeting receptors onto a patient's own immune cells is now being explored by scientists from Duke-NUS Medical School (Duke-NUS), as a potential therapy for controlling infectious diseases, including the COVID-19-causing virus, SARS-CoV-2.

22 Apr 2020

The race is on for a coronavirus vaccine, 70 candidates, 3 at human trial stage

Amid the coronavirus disease (COVID-19) global pandemic that is infecting millions of people across the globe, hope sparks as the World Health Organization (WHO) reports that seventy vaccination trials for the novel coronavirus are underway, with three already at the human trial stage.

14 Apr 2020

New techniques could help neuroscientists track brain computations

Since the 1950s at least, researchers have speculated that the brain is a kind of computer in which neurons make up complex circuits that perform untold numbers of calculations every second. Decades later, neuroscientists know that these brain circuits exist, yet technical limitations have kept most details of their computations out of reach.

14 Dec 2019

New technology may offer alternative means of profiling tissues

Current cancer treatment courses often begin with tissue biopsies. Biopsies, however, which involve the physical resection of a small tissue sample, can lead to localized tissue injury, bleeding, inflammation, and stress, as well as increased risk of metastasis.

19 Nov 2019

Deterministic mechanoporation of cells en masse to cure cancer

What if you could cure cancer by re-engineering patients' cells to better target and destroy their own tumors? With the advent of powerful new cellular engineering technologies, this is no longer the stuff of science fiction.

13 Nov 2019

NUS researcher invents novel transfection technique to deliver DNA into immune cells

Immunotherapy is a promising cancer treatment that uses genetically modified immune cells to fight cancer. It can be used as a primary treatment or in combination with other treatments such as radiation and chemotherapy to slow down or stop the growth of cancer cells and prevent them from spreading to other parts of the body.

4 Oct 2019

No more tears: immunization without needles

A new study published in the Journal of Investigative Dermatology reports a novel skin vaccine patch which could help effective and safe immunization by disrupting the permeability of the skin, providing a convenient and non-invasive alternative to immunization shots. This innovative technique now needs to be tested in humans.

17 Sep 2019

Researchers develop new gene editing system that could be used for anticancer immunotherapy

Dr. Mihue Jang and her group at the Center for Theragnosis of the Korea Institute of Science and Technology announced that they have developed a new gene-editing system that could be used for anticancer immunotherapy through the simultaneous suppression of proteins that interfere with the immune system expressed on the surface of lymphoma cells and activation of cytotoxic T lymphocyte, based on the results of joint research conducted with Prof. Seokmann Hong and his group at Sejong University.

20 Aug 2019