Embryonic Stem Cells News and Research

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LJI scientists uncover how OGT enzyme keeps cells healthy

Researchers at La Jolla Institute for Immunology have at last uncovered how an enzyme called O-GlcNAc transferase (OGT) keeps cells healthy.

12 Jan 2023

'Epigenetic fingerprints' of prenatal alcohol exposure could be biomarkers to detect developmental disorders

Alcohol exposure in early pregnancy can change gene function during the tightly regulated embryonic development, and consequently cause developmental disorders - especially neurodevelopmental disorders.

3 Jan 2023

Scientists provide metrics for organ development

Organs in the human body have complex networks of fluid-filled tubes and loops. They come in different shapes and their three-dimensional structures are differently connected to each other, depending on the organ.

21 Nov 2022

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

15 Nov 2022

New breakthrough in understanding how deletion of certain genes can lead to cancer growth

Genetic mutations kick start cancers. Some mutations shuffle the genetic code, others come from the deletion of key genes.

28 Oct 2022

Ancient viral DNA in human genomes protects cells against present-day viruses

Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.

27 Oct 2022

Role of the transketolase-like 1 gene in the development of the modern human brain

In a new study, researchers demonstrated how transketolase-like 1 (TKTL1) gene expression influenced neocortical neurogenesis in modern humans.

12 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial mutations to observe these tiny organelles.

30 Aug 2022

Mouse embryoids offer a promising model system to spur research into embryonic development and disease

Scientists funded in part by the National Institutes of Health have generated a mouse embryo model, or embryoid, that develops beyond neurulation—formation of the neural tube, which gives rise to the central nervous system—and closely mirrors natural mouse embryos 8.5 days after fertilization.

25 Aug 2022

Scientists explore ex utero generation of post-gastrulation synthetic embryos

Researchers showed that post-gastrulation synthetic embryos (sEmbryos) could be synthesized outside the uterus using mouse naive embryonic stem cells (ESCs).

9 Aug 2022

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Researchers develop a genetically modified airway organoid system, which overcomes challenges related to natural variations in ACE2 levels

4 Aug 2022

A major breakthrough toward new treatments for Type 1 and Type 2 diabetes

A world-first study by Monash University, in Melbourne, Australia has discovered a pathway to the regeneration of insulin in pancreatic stem cells, a major breakthrough toward new therapies to treat Type 1 and Type 2 diabetes.

22 Jul 2022

First-of-its-kind roadmap reveals how stem cells become sensory interneurons

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind roadmap detailing how stem cells become sensory interneurons -; the cells that enable sensations like touch, pain and itch.

19 Jul 2022

Embryonic Stem Cells News and Research

LJI scientists uncover how OGT enzyme keeps cells healthy

'Epigenetic fingerprints' of prenatal alcohol exposure could be biomarkers to detect developmental disorders

Scientists provide metrics for organ development

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

New breakthrough in understanding how deletion of certain genes can lead to cancer growth

Ancient viral DNA in human genomes protects cells against present-day viruses

Role of the transketolase-like 1 gene in the development of the modern human brain

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Mouse embryoids offer a promising model system to spur research into embryonic development and disease

Scientists explore ex utero generation of post-gastrulation synthetic embryos

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

A major breakthrough toward new treatments for Type 1 and Type 2 diabetes

First-of-its-kind roadmap reveals how stem cells become sensory interneurons

New protocol can develop safe, efficient pluripotent stem cell-based therapies for macular degeneration

New research reveals a potent weapon against Parkinson's disease

Sen. Orrin Hatch’s legacy tracks the GOP’s evolution on health

Study shows how cells use octopus-like tentacles to move around the body

Using CRISPR/Cas to develop biosafety materials

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

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