Endoplasmic reticulum (ER) News and Research

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Endoplasmic reticulum stress in the brain may cause non-alcoholic fatty liver disease

Disruptions in a protein folding process occurring in the brain, known as endoplasmic reticulum (ER) stress, may cause non-alcoholic fatty liver disease, independent of other factors. A research team at the George Washington University published their results in the Journal of Clinical Investigation Insight.

25 May 2017

IDIBELL researchers reveal role of endoplasmic reticulum in cell death process due to starvation

Researchers from the Cell death group of the Bellvitge Biomedical Research Institute, led by Dr. Cristina Muñoz-Pinedo, have characterized the cell death process due to starvation, in which the endoplasmic reticulum plays a leading role.

3 May 2017

Scientists receive $2.8 million federal grant for diabetic cardiomyopathy research

Researchers from Georgia State University's Center for Molecular & Translational Medicine have received a four-year, $2.8 million federal grant to study diabetic cardiomyopathy, diabetes-related changes in the structure and function of the heart muscle.

24 Apr 2017

ER visits may serve as effective 'teachable moments' for drug use, study suggests

An emergency room visit for an illness or injury may seem like a strange time to try to motivate someone to cut back on using drugs.

13 Mar 2017

Mite-proof covers may reduce severity of asthma exacerbations in allergic children

Bedcovers that form a barrier to house dust mites appear to reduce asthma flare-ups in children, according to new research published online, ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

From The University of Manchester 10 Mar 2017

Caffeine may protect lungs from damage caused by prolonged oxygen therapy, study finds

A new study finds that caffeine may protect the lungs from damage caused by prolonged oxygen therapy, such as oxygen supplementation given to premature babies.

8 Mar 2017

Researchers reveal how overloading of protein transport mechanisms triggers cellular defects

Researchers at Okayama University report in Scientific Reports how the overloading of protein transport mechanisms affects cell functioning. Over-expression of different types of target proteins leads to cellular growth defects, and the mechanism for transporting proteins out of a cell nucleus has the lowest over-expression tolerance.

7 Mar 2017

Study identifies protein that may offer protection against heart disease

A protein found in the heart that is known to be involved in cellular stress responses in cancer cells is now believed to play a critical role in the ability of cardiac cells to combat heart disease and recover from a heart attack.

6 Mar 2017

Community-based palliative care linked to reduction in ER visits for dying patients

Community-based palliative care -- care delivered at home, not the hospital -- was associated with a 50 percent reduction in emergency department visits for patients in their last year of life.

22 Feb 2017

U-M researchers envision new ways to avoid inappropriate ER use for mild eye problems

Pinkeye isn't a medical emergency. Neither is a puffy eyelid. But a new study finds that nearly one in four people who seek emergency care for eye problems have those mild conditions, and recommends ways to help those patients get the right level of care.

15 Feb 2017

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

Nicotine -- the primary compound found within tobacco smoke -- is known to change the grouping of some subtypes of nicotinic receptors, but the mechanisms for nicotine addiction remain unclear.

15 Feb 2017

Researchers find drugs that could replicate effects of gastric bypass surgery

Gastric bypass surgery is one of the most successful treatments for obesity and related disorders; however, some patients may not want to undergo surgery.

8 Feb 2017

PERK protein could be target for development of new drugs for progressive supranuclear palsy

The brain disease "progressive supranuclear palsy" (PSP) is currently incurable and its symptoms can only be eased to a very limited degree. PSP impairs eye movements, locomotion, balance control, and speech.

6 Feb 2017

SNAP program may be beneficial in reducing ER visits for hypoglycemia

In 2014, the Supplemental Nutrition Assistance Program, a federal program to address food insecurity in the United States, provided $70 billion in nutrition support to 46.5 million families and children living in 22.7 million American households.

1 Feb 2017

Penn researchers attempting to harness power of big data to help cancer patients avoid ER visits

What if doctors could look into a crystal ball and predict which of their patients might be at risk of getting sick enough to go to the emergency room?

30 Jan 2017

Exeter scientists discover how two cell organelles interact at molecular level

Scientists have made a breakthrough in understanding how different compartments (or organelles) of human cells interact.

20 Jan 2017

Study shows structural impact of membrane lipids on medically relevant serotonin transporters

Neurotransmitter transporters are some of the most popular transport proteins in research as they play a major role in the processing of signals in the brain. A joint study by TU Wien and the Medical University of Vienna has now successfully demonstrated for the first time the structural impact of membrane lipids on medically relevant serotonin transporters.

19 Jan 2017

Study provides insights into CPEB4 gene and fatty liver disease

This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease.

18 Jan 2017

Technology and cost barriers hinder real-time reporting of cancer patients' symptoms

Capturing real-time reports of cancer patients' symptoms between doctor's visits has proven health benefits, but technology and cost barriers are getting in the way of widespread adoption of the practice, reports a University of North Carolina Lineberger Comprehensive Cancer Center researcher.

12 Jan 2017

Study examines role of risk factors in development of ER-positive and ER-negative breast cancers

Karla Kerlikowske, MD, and team recently published a paper in the Journal of the National Cancer Institute that examined the role of common risk factors in the development of ER-positive and ER-negative breast cancers.

10 Jan 2017