Endoplasmic reticulum (ER) News and Research

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Impact of health messages in entertainment

A new study by researchers at the University of Southern California suggests that some TV may be good for you. Researchers found that a storyline on the primetime NBC network drama ER that dealt with teen obesity, hypertension and healthy eating habits had a positive impact on the attitudes and behaviors of viewers, particularly among men.

18 Sep 2007

TFAP2C gene may be useful target for new breast cancer therapies

University of Iowa researchers have discovered a gene that plays a linchpin role in the ability of breast cancer cells to respond to estrogen.

17 Sep 2007

Mutations in the insulin gene can cause permanent neonatal diabetes

Mutations in the insulin gene can cause permanent neonatal diabetes, an unusual form of diabetes that affects very young children and results in lifelong dependence on insulin injections, report researchers from the University of Chicago and Peninsula University (Exeter, UK) in Sept. 18, 2007, issue of the Proceedings of the National Academy of Sciences, published early online.

11 Sep 2007

Clearer picture of how a dividing cell rebuilds the nuclear envelope

Just how a dividing cell rebuilds the nuclear envelope, the protective, functional wrapping that encases both the original and newly copied genetic material, has been a source of controversy for the last 20 years.

10 Sep 2007

New understanding of endoplasmic reticulum

In obese individuals, fat cells are bloated and inflamed because they receive too many nutrients, including lipids.

29 Aug 2007

Oestrogen research points to new class of analgesic drugs

Oestrogen plays an important role in determining how sensitive a person is to pain, and the oestrogen receptor known as ER-beta is particularly significant in this context.

13 Aug 2007

Mylan receives FDA approval for Verapamil Hydrochloride capsules

Mylan Laboratories Inc. has announced that Mylan Pharmaceuticals Inc. has received final approval from the U.S. Food and Drug Administration for its Abbreviated New Drug Application (ANDA) for Verapamil Hydrochloride (HCl) Extended-release (ER) Capsules (PM), 100 mg, 200 mg and 300 mg.

13 Aug 2007

Actavis receives FDA OK for generic Inderal capsules

Actavis Group has announced that it has received approval from the U.S. Food & Drug Administration to market Propranolol Hydrochloride extended-release capsules. Distribution of the product will commence immediately.

13 Aug 2007

HMGB1 protein shown to act as an accelerator - activating the body's defenses

Toll-like receptors are the guard dogs of the immune system, sniffing out bacteria and viruses then activating the body's immune system for an attack on these invaders.

3 Aug 2007

Key signs of appendicitis

A 5-year-old with abdominal pain, nausea and fever may have appendicitis or any of a number of other problems.

3 Aug 2007

Test scores were stronger before 'No Child Left Behind' was approved in 2002

As Congress reviews federal efforts to boost student performance, new research published in Educational Researcher (ER) reports that progress in raising test scores was stronger before No Child Left Behind was approved in 2002, compared with the four years following enactment of the law.

1 Aug 2007

Court rules in favor of Sandoz on Toprol Xl patent

Sandoz was pleased to learn this week that the U.S. Court of Appeals in St. Louis has affirmed a summary judgment by U.S. District Judge Rodney Sippel invalidating patent protection on Toprol XL(R), a beta blocker used to treat angina, heart failure, and high blood pressure.

26 Jul 2007

Group therapy does not prolong the lives of women with metastatic breast cancer

Earlier results from the same researcher had suggested a survival benefit of group therapy for women with metastatic breast cancer. However, the new study did find that women with estrogen receptor (ER) negative tumors did show survival benefit, and that group therapy improved quality of life (QOL).

23 Jul 2007

Cholesteryl ester transfer protein may also influence how fat cells store fat

Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat.

20 Jul 2007

Continuous support for women during childbirth

When it comes to giving birth, some traditional approaches could result in happier and healthier moms and newborns, according to two research reviews.

18 Jul 2007

Src inhibitors may prove beneficial in breast cancer therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development.

13 Jul 2007

High-tech dental lasers eliminate bacteria in root canals

High-tech dental lasers used mainly to prepare cavities for restoration now can help eliminate bacteria in root canals, according to research published in the July issue of The Journal of the American Dental Association (JADA).

13 Jul 2007

Hormone therapy can extend life in ovarian cancer patients

The study, published in Clinical Cancer Research, has proved for the first time that the targeted use of an anti-oestrogen drug could prolong the life of some patients by up to three years, and delay the use of chemotherapy in others.

17 Jun 2007

Researchers find new mechanism of action of the anti-cancer drug sorafenib

Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new mechanism of action of the anti-cancer drug sorafenib, which could stimulate the development of novel regimens in which it is combined with other molecularly targeted agents for patients with blood cancers and solid tumors.

15 Jun 2007

MRI detects cancers missed by mammography in breast cancer patients

A unique examination of one treatment center's use of magnetic resonance imaging (MRI) in new breast cancer patients has found MRI to be superior to mammography in finding additional tumors in a breast in which cancer has already been diagnosed, and in detecting new tumors in a patient's supposedly healthy breast.

5 Jun 2007