Endoplasmic reticulum (ER) News and Research

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700,000 adverse drug events in the U.S. each year lead to ER visits

Each year, an estimated 700,000 persons experience adverse drug events that lead to emergency department visits, according to a study in the October 18 issue of JAMA: The Journal of the American Medical Association.

17 Oct 2006

New avenue for the pursuit of therapies for Alzheimer's disease

The genes responsible for an inherited form of Alzheimer's disease play a direct role within cells that has largely been overlooked, according to a report in the September 8, 2006 issue of the journal Cell.

7 Sep 2006

GenoMed's West Nile virus trial endorsed by expert

GenoMed has announced the endorsement of its trial for West Nile virus encephalitis by an authority in Emergency Medicine, Dr. Neal Handly.

8 Aug 2006

Gleevec may cause heart problems

Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart.

24 Jul 2006

FoxM1 regulates the expression of oestrogen receptors in breast cancer

Research just published online in the "Journal of Biological Chemistry" identifies a new molecule involved in the regulation of oestrogen receptors (ER) expression in breast cancer.

12 Jul 2006

Scientists identify overactive protein that plays a key role in cystic fibrosis

A team led by Johns Hopkins Children's Center scientists has identified and successfully tamed an overactive protein that plays a key role in cystic fibrosis (CF), a genetic disorder that interferes with the body's ability to transport chloride in and out of cells.

5 Jul 2006

Calpain protein key to preventing or promoting cell death

A protein called calpain can be the key either preventing or promoting the cell death, a Queen's University study has found.

6 Jun 2006

Scientists map the entire active protein inventory in cells

Scientists have shown how cutting-edge methods can be used to catalogue the entire inventory of active proteins in cell organelles at a particular moment. Their work sheds considerable light on how cells use proteins.

29 May 2006

Misuse of ADHD drugs sends thousands each year to seek emergency hospital treatment

Scientists at the U.S. Centers for Disease Control and Prevention (CDC) have estimated that problems with the drugs used to treat attention deficit disorders force as many as 3,100 people to seek emergency hospital treatment each year.

25 May 2006

Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the Journal of the National Cancer Institute.

17 May 2006

Effectiveness of radiation therapy for older women with early breast cancer

Elderly women with early-stage breast cancer had a lower risk of recurrence when they were treated with radiation therapy, according to a study in the Journal of the National Cancer Institute.

17 May 2006

Caspase-12 antagonists could potentially be useful in the treatment of sepsis and other inflammatory and immune disorders

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

26 Apr 2006

Advances in chemotherapy significantly reduce risk of disease recurrence in breast cancer patients

Recent advances in chemotherapy have significantly reduced the risk of disease recurrence and death in breast cancer patients whose tumors are not hormone sensitive, according to a study by researchers at Dana-Farber Cancer Institute and 10 other institutions.

13 Apr 2006

Cardiocerebral resuscitation improves survival of patients with out-of-hospital cardiac arrest

Survival rates following the most common form of cardiac arrest increased three-fold when emergency medical personnel used a new form of CPR developed at The University of Arizona Sarver Heart Center.

13 Apr 2006

Essential information - how to deal with a serious allergic reaction

Hundreds of Americans die each year from anaphylaxis which is a serious allergic reaction that is rapid in onset and may cause death.

7 Mar 2006

Research highlights importance of detecting anthrax early

When spores sent through the mail in 2001 caused 11 people to contract anthrax - ultimately killing five of them - infectious disease specialists noted that the death rate was substantially lower than the historical mortality rate, which approached 100 percent.

24 Feb 2006

New mechanism that regulates K-Ras - protein that plays an important role in cancer

Researchers have discovered a protein widely known to cause the out-of-control growth of cells can actually be manipulated to induce those cells to commit suicide, providing a novel target for the development of anti-cancer drugs, according to the results of a new study led by New York University School of Medicine researchers.

21 Feb 2006