Endoplasmic reticulum (ER) News and Research

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Cell phones speed heart attack treatment

A Michigan hospital has cut in half the time it takes to begin life-saving treatment of heart attack patients by using cell phones to transmit electrocardiograms (ECGs) from the field

16 Oct 2005

Researchers find gene that is important for the control of fundamental rhythms in nematode worms

University of Utah biologists found a gene that controls rhythmic events in a worm's life: swallowing food, laying eggs and pooping.

9 Oct 2005

Researchers identify gene defect in mice that causes cyclical hair loss and skin cancer

Researchers at Jefferson Medical College and at the Wadsworth Center in New York have identified a gene defect in mice resulting in a range of abnormalities, from cyclical hair loss and skin cancer to severe problems in normal skin development.

4 Oct 2005

People use discretion in deciding when show up in the emergency department

When is a medical emergency really an emergency? Not during key Boston Red Sox games, report investigators from Children's Hospital Boston in a letter published in the October issue of Annals of Emergency Medicine.

26 Sep 2005

John Hopkins scientists uncover "tags" that force proteins to cell surface

Johns Hopkins scientists have discovered internal "shipping labels" that allow -- and perhaps force -- hundreds if not thousands of proteins to get to the surface of cells and stay there.

22 Sep 2005

Translation elongation factor eEF1A2 is is a potential oncogene that is overexpressed in two-thirds of breast tumors

The tissue-specific elongation factor eEF1A2 might be an oncoprotein involved in breast cancer.

12 Sep 2005

GenoMed has announced that it successfully treated its thirteenth patient with presumed West Nile virus encephalitis

The patient is a previously healthy man from Aberdeen, South Dakota who developed fever and headache and was diagnosed by his physician as having West Nile virus on Monday of this week. South Dakota has about 50 times higher incidence of West Nile virus this summer than California.

1 Sep 2005

Unrecognized hypertension is common among emergency room patients, especially African Americans

Half of the study participants with high blood pressure reported that they were not under medical care for the condition. Further, the majority of this group stated that they had never been told that they had high blood pressure.

1 Sep 2005

First evidence that complex genetic interactions account for autism risk

Using a novel analysis of the interactions among related genes, Duke University Medical Center researchers have uncovered some of the first evidence that complex genetic interactions account for autism risk. The Duke team found that the brain mechanism that normally stops or slows nerve impulses contributes to the disease.

3 Aug 2005

Protein called cyclin D1 disrupts BRCA1's normal role as a cancer inhibitor

For about a decade, scientists have recognized that many cases of hereditary breast cancer result from a mutation of a specific gene called BRCA1, which, in its normal state, helps keep tumor formation in check. About five to 10 percent of breast cancer cases are linked to genetic miscues, about half of which are linked to BRCA1.

2 Aug 2005

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents through a cellular stress response that activates a pro-survival protein called GRP78, according to researchers from the Keck School of Medicine of the University of Southern California.

6 Jul 2005

Test accurately predicts aggressiveness of breast cancer

A test that measures how quickly cells are dividing is an accurate way for doctors to predict the aggressiveness of breast cancer tumors, even among women with very early stages of the disease, researchers told the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary.

6 Jun 2005

New approach to inhibiting blood vessel growth or angiogenesis

A manmade protein with a tail of amino acids delivered to target cells can dramatically reduce blood vessel growth that obstructs vision or feeds a tumor, researchers have found.

31 May 2005

Ibuprofen use is associated with an increased risk of breast cancer

Ibuprofen use is associated with an increased risk of breast cancer, and long-term daily use of aspirin is associated with an increased risk of estrogen receptor/progesterone receptor (ER/PR)-negative breast cancer, according to a new study in the June 1 issue of the Journal of the National Cancer Institute.

30 May 2005

Don’t skip chest CT in the ER just because X-ray checks out okay, warns study

Chest X-rays may miss 40% of clinically significant thoracic injuries in multiple trauma patients that can be caught by chest CT, say researchers from Massachusetts General Hospital in Boston.

18 May 2005

New drug combination prevents breast cancer growth pre-surgery

A new type of drug originally developed for lung cancer can reduce the size of breast cancer tumours when taken in combination with other drugs.

17 May 2005

Zometa reduces bone loss in patients receiving breast cancer treatment

Data presented at the American Society of Clinical Oncology (ASCO) annual meeting in Orlando, Florida, demonstrate that Zometa (zoledronic acid), an intravenous bisphosphonate, was shown to inhibit bone loss in postmenopausal women treated with Femara (letrozole) in the adjuvant breast cancer setting (directly following surgery to prevent cancer recurrence).

16 May 2005

75,000 children end up in hospital emergency rooms due to trampoline injuries

Linakis states quite categorically that the home environment and even the school environment are not the place for trampolines. He says though it will not be a popular idea, trampolines are only appropriate in very select, heavily supervised environments, such as a gymnastics school.

15 May 2005

Millions of employed Americans uninsured and unable to get Medical Care

A new study analyzing data from the Centers for Disease Control and Prevention shows that a significant number of working Americans in every state do not have health care coverage, with more than 20 million working adults not having coverage. In eight states, at least one in five working adults is uninsured.

27 Apr 2005

P12 protein influences key cell-signaling pathway

New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body.

26 Apr 2005