Endothelial cell News and Research

RSS

Mode of action of EpiCept-licensed cancer compound profiled at AACR

EpiCept Corporation has reported that studies characterizing a dual mode of action for Azixa, a compound licensed by the Company to Myriad Genetics, Inc.

24 Apr 2007

Scientists tackle cancer with different approaches

Studies presented at the 2007 meeting of the American Association for Cancer Research show how researchers are using the new, as well as the natural, to help design and test new drugs to treat cancer.

18 Apr 2007

Researchers identify new player in the 'fat from food' game

UCLA investigators have identified a new molecule that may help regulate the delivery of fats to cells for energy and storage.

4 Apr 2007

Scientists identify new molecule that may help regulate the delivery of fats to cells

Published in the April issue of the journal Cell Metabolism, the finding could lead to a better understanding of how we utilize fats from the foods we eat.

4 Apr 2007

Adding estradiol to a polymer-free rapamycin-eluting stent is not associated with any measurable benefit

Patients admitted to the hospital with acute coronary syndromes (ACS) are often treated with a catheter-based procedure known as percutaneous coronary intervention (PCI), during which a stent is inserted into an occluded or narrowed coronary artery to restore blood flow to and from the heart.

2 Apr 2007

Link between growth of blood vessels critical to spread of cancer and copper in our bodies

Growing new blood vessels from existing ones - a process called angiogenesis - is important in growth, development and wound healing. But it also enables the spread of tumors throughout the body, so researchers have been scrambling for ways to stop angiogenesis in the fight against cancer.

28 Feb 2007

Dll4 signalling through Notchi regulates formation of tip cells during angiogenesis

All tissues, sick and healthy alike, need a blood supply to survive and grow. The key to many medical problems, like preventing tumour development, is therefore to obstruct the spread of the blood vessels. Research scientists at Karolinska Institutet have now discovered a heretofore unknown mechanism for how the body links together its blood vessels.

29 Jan 2007

FoxOs shown to be potential new targets for cancer drugs

In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

29 Jan 2007

Why COX-2 inhibitors such as Vioxx can cause heart attacks and strokes

COX-2 inhibitors are primarily used to treat pain in conditions such as arthritis. They work by blocking the COX-2 enzyme, which is expressed at sites of inflammation and underlies the production of hormones called prostaglandins which swell the joints and cause the feeling of pain.

2 Dec 2006

Safety of t-PA clot-busting therapy questioned

Across the world, emergency medical teams often administer a powerful clot-busting drug called tissue plasminogen activator (t-PA) to help patients stricken by heart attack.

13 Nov 2006

Multivalent effects of RGD peptides obtained by nanoparticle display

While a growing body of literature has shown that nanoparticle targeting can improve drug delivery and tumor imaging, there have been few systematic studies examining the net positive effect of nanoparticle targeting.

23 Oct 2006

Carbon monoxide shown to reverse symptoms of pulmonary hypertension

In a medical case of Jekyll and Hyde, carbon monoxide - the highly toxic gas emitted from auto exhausts and faulty heating systems - has proven effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating condition that typically leads to right heart failure and eventual death.

20 Sep 2006

The murine abdominal adipose stromal cell compartment supports the differentiation into endothelial, but not into hematopoietic progenitor cells

World Congress of Cardiology Report - Post-infarct regeneration of the damaged myocardium is critical for treatment of patients with acute coronary syndrome or myocardial infarction.

5 Sep 2006

The heart can heal itself

World Congress of Cardiology Report - Despite the dramatic advances in the care of patients with cardiovascular diseases that have occurred in the second half of the 20th century, heart failure (HF) is the most common cause of death in developed nations.

5 Sep 2006

Specialized skin cells use GPS like mapping system to identify where they belong in the body

Until now it's been a mystery as to how adult skin, which consists of basically the same components all over the body, knows to grow hair in some areas like the scalp, while manufacturing sweat glands, calluses and fingerprint whorls in others

2 Aug 2006

Mechanics of atherosclerosis

Atherosclerotic narrowing and hardening of coronary arteries typically appear first at vessel branches, and a study in the October issue of Cellular Signalling reports that the type of mechanical stretching found at those branches activates a cellular protein known to damage cells.

12 Jul 2006

Japanese researchers using PET imaging detect the beginnings of atherosclerosis

Using positron emission tomography (PET), the medical isotope 15O-water and cold pressor tests, Japanese researchers were able to detect the beginnings of atherosclerosis - before the disease became clinically evident.

9 Jun 2006

Discovery of new defect in artery growth

From the beginning, arteries and veins are different in the way they branch into vascular networks, say Dartmouth heart researchers.

9 Jun 2006

Gleevec strangles drug-resistant, metastatic prostate cancer

A medication used to treat other types of cancer strangles drug-resistant, metastatic prostate cancer by cutting off its blood supply, researchers from The University of Texas M. D. Anderson Cancer Center report in the June 7 issue of the Journal of the National Cancer Institute.

7 Jun 2006