Eukaryotic cell News and Research

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New insights into Legionella pneumophila

A study published online in Genome Research (www.genome.org) describes new insights into Legionella pneumophila, the bacteria responsible for most cases of Legionnaires' disease.

7 Feb 2008

Novel method for assigning probabilities to human protein interactions

The Stowers Institute's Proteomics Center has published a novel method of using normalized spectral counts derived from a series of affinity purifications analyzed by mass spectrometry (APMS) to generate a probabilistic measure of the preference of proteins to associate with one another.

25 Jan 2008

Model developed that predicts molecular response of living cells to genetic or environmental change

Scientists at the Institute for Systems Biology (ISB), in collaboration with researchers from New York University (NYU), have developed a model which rapidly characterizes and accurately predicts the molecular-level, mechanistic response of a free-living cell to genetic and environmental changes.

28 Dec 2007

Researchers report protein interactions of MAP kinase signaling pathway

The Stowers Institute's Rong Li Lab, in collaboration with the Institute's Imaging Center, has achieved a quantitative in vivo measurement of the dynamic protein-protein interactions in the mitogen-activated protein (MAP) kinase cascade signaling pathway, which is critical to growth and differentiation decisions in all eukaryotic cells.

14 Dec 2007

Scientists seek to assess the microbial risks in the water we drink

It is a familiar scenario experienced around the world: an outbreak of gastrointestinal illness suddenly emerges in a community, and no one knows where it came from or how to stop it. At the start of the outbreak, only a few people are affected, most often the very old and the very young.

12 Dec 2007

Pathogens use previously undescribed mechanism to sabotage host immune system

New research identifies a previously unknown enzymatic mechanism that subverts the early host immune response and promotes pathogenicity by manipulating a common signaling pathway in host cells.

10 Dec 2007

Tainted spinach reveals treatment possibilities

A discovery by University at Buffalo biologists that may explain the evolution of a lethal toxin is providing new information that could lead to more effective treatments for humans who fall victim to it.

3 Dec 2007

New genetic findings on malaria parasite

The malaria parasite has been studied for decades, but surprisingly, little is known about how it behaves in humans to cause disease.

29 Nov 2007

Regulation of TATA-less promoters

In their upcoming G&D paper, Dr. Robert Tjian (UC Berkeley) and colleagues reveal how histone gene expression is differentially regulated during Drosophila development.

2 Nov 2007

Discovery of protein that plays a key role in the recycling of iron from blood

Scientists working in the only lab at MIT doing hematology research have uncovered a protein that plays a key role in the recycling of iron from blood. Their work, described in the October 11 Journal of Clinical Investigation, could lead to new therapies for certain inherited blood disorders such as beta-thalassemia, a condition that causes chronic anemia.

12 Oct 2007

How Candida albicans transforms from its normally benign form into life-threatening form

Researchers at the Agency for Science, Technology and Research's (A*STAR) Institute of Molecular and Cell Biology (IMCB) have discovered new molecular mechanisms that provide a more detailed understanding of how the normally benign Dr. Jekyll-like fungus known as Candida albicans transforms into a serious and often life-threatening Mr. Hyde-like form.

4 Oct 2007

Protein architectures provide window on the history of life

The present can tell you a lot about the past, but you need to know where to look.

2 Oct 2007

Genetic sequence of Giardia complete

Giardia lamblia, one of the most common human parasites in the United States, causes more than 20,000 intestinal infections a year, often through contact with contaminated drinking or swimming water.

27 Sep 2007

RecA family recombinases repair DNA damages

A biochemistry research team led by Dr. Andrew H.-J. Wang and Dr. Ting-Fang Wang at the Institute of Biological Chemistry, Academia Sinica(IBCAS), has discovered that the RecA family recombinases function as a new type of rotary motor proteins to repair DNA damages.

13 Sep 2007

All eukaryotic kinases share 1 common set of substrates

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death.

24 Aug 2007

Chromatin remodeling complex connected to DNA damage control

When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.

12 Aug 2007

How cells change the pace of their steps

Scientists at UC San Diego have discovered how cells of higher organisms change the speed at which they move, a basic biological discovery that may help researchers devise ways to prevent cancer cells from spreading throughout the body.

7 Aug 2007

Immunity in social amoeba suggests ancient beginnings

Finding an immune system in the social amoeba (Dictyostelium discoideum) is not only surprising but it also may prove a clue as to what is necessary for an organism to become multicellular, said the Baylor College of Medicine researcher who led the research that appears in the journal Science.

3 Aug 2007

Targeting key proteins of carcinogenesis

Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome.

23 Jun 2007

New targets for Leishmaniasis

A comparison of three parasite species that cause Leishmaniasis has identified a small number of genes, many new to biology, that will provide a framework to target the search for new treatments.

19 Jun 2007